Bones and Crohn's: Estradiol deficiency in men with Crohn's disease is not associated with reduced bone mineral density

BMC Gastroenterology

Volumn 8, Issue , 2008, Pages

  Klaus, Jochen ^a   Reinshagen, M ^b   Adler, Guido ^a   Boehm, Bernhard O ^a   von Tirpitz, Christian ^c  

^a UNIVERSITY OF ULM   (Germany)

^b KLINIKUM BRAUNSCHWEIG   (Germany)

^c Medizinische Klinik   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; BIOLOGICAL MARKER; CARBOXY TERMINAL TELOPEPTIDE; CORTICOSTEROID; ESTRADIOL; OSTEOCALCIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; ICTP PEPTIDE; PEPTIDE FRAGMENT; PROCOLLAGEN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BONE DENSITOMETRY; BONE DENSITY; BONE METABOLISM; BONE TURNOVER; CONTROLLED STUDY; CORRELATION ANALYSIS; CROHN DISEASE; DISEASE ACTIVITY; DISEASE ASSOCIATION; ESTRADIOL BLOOD LEVEL; HORMONE BLOOD LEVEL; HORMONE DEFICIENCY; HORMONE DETERMINATION; HUMAN; LONG TERM EXPOSURE; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; OSTEOPENIA; STEROID THERAPY; BLOOD; BONE; CASE CONTROL STUDY; METABOLISM; MIDDLE AGED; OSTEOPOROSIS; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; AGED; BIOLOGICAL MARKERS; BONE AND BONES; BONE DENSITY; CASE-CONTROL STUDIES; CROHN DISEASE; DIHYDROTESTOSTERONE; ESTRADIOL; HUMANS; MALE; MIDDLE AGED; OSTEOCALCIN; OSTEOPOROSIS; PEPTIDE FRAGMENTS; PROCOLLAGEN; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; YOUNG ADULT;

EID: 55949127426     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-8-48     Document Type: Article

References (38)

1. Compston JE Judd D Crawley EO Evans WD Evans C Church HA Reid EM Rhodes J Osteoporosis in patients with inflammatory bowel disease Gut 1987, 28(4):410-415. 1432817 3583068 10.1136/gut.28.4.410
2. Abitbol V Roux C Chaussade S Guillemant S Kolta S Dougados M Coutourier D Amor B Metabolic bone assessment in patients with inflammatory bowel disease Gastroenterology 1995, 108(20):417-422. 10.1016/ 0016-5085(95)90068-3 7835582
3. Bernstein CN Seeger LL Sayre JW Anton PA Artinian L Shanahan F Decreased bone density in inflammatory bowel disease is related to corticosteroid use and not disease diagnosis J Bone Miner Res 1995, 10(2):250-256. 7754804
4. Bjarnason I Macpherson A Mackintosh C Buxton-Thomas M Forgacs I Moniz C Reduced bone density in patients with inflammatory bowel disease Gut 1997, 40(2):228-233. 1027054 9071937
5. von Tirpitz C Pischulti G Klaus J Rieber A Brueckel J Boehm BO Adler G Reinshagen M Pathological bone density in chronic inflammatory bowel disease - prevalence and risk factors Z Gastroenterol 1999, 37(1):5-12. 10091278
6. Tobias JH Sasi MR Greenwood R Probert CS Rapid hip bone loss in active Crohn's disease patients receiving short term corticosteroid therapy Aliment Pharmacol Ther 2004, 20(9):951-957. 10.1111/ j.1365-2036.2004.02207.x 15521842
7. Siffiledeen JS Fedorak RN Siminoski K Jen H Vaudan E Abraham N Steinhart H Greenberg G Bones and Crohns disease: Risk factors associated with low bone mineral density in patients with Crohns disease Inflamm Bowel Dis 2004, 10(3):220-228. 10.1097/00054725-200405000-00007 15290915
8. Klaus J Armbrecht G Steinkamp M Brueckel J Rieber A Adler G Reinshagen M Felsenberg D von Tirpitz C High prevalence of osteoporotic vertebral fractures in patients with Crohn's disease Gut 2002, 51:654-658. 1773437 12377802 10.1136/gut.51.5.654
9. Van Staa TP Cooper C Brusse LS Leufkens H Javaid MK Arden NK Inflammatory bowel disease and the risk of fracture Gastroenterology 2003, 125:1591-1597. 10.1053/j.gastro.2003.09.027 14724810
10. Pooran N Singh P Bank S Crohn's disease and risk of fractures: Does thyreoid disease play a role? World J Gastroenterol 2003, 9(3):615-618. 12632531
11. Loftus EV jr Achenbach SJ Sandborn WJ Tremaine WJ Oberg AL Melton LJ 3rd Risk of fracture in ulcerative colitis: A population-based study from Olmsted County, Minnesota Clin Gastroenterol Hepatol 2005, 1(6):465-73. 15017646 10.1016/S1542-3565(03)00185-X
12. Van Staa TP Leufkens HGM Cooper C The Epidemiology of Corticosteroid-Induced Osteoporosis: A Meta-analysis Osteoprosis Int 2002, 13:777-787. 10.1007/s001980200108
13. von Tirpitz C Epp S Klaus J Mason R Hawa G Brinskelle-Schmal N Hofbauer LC Adler G Kratzer W Reinshagen M Effect of systemic glucocorticoid therapy on bone metabolism and the osteoprotegerin system in patients with active Crohns disease Eur J Gastroenterol Hepatol 2003, 15(11):1165-70. 10.1097/00042737-200311000-00003 14560148
14. Tilg H Moschen AR Kaser A Pines A Dotan I Gut, inflammation and osteoporosis: Basic and clinical concepts Gut 2008, 57(5):684-94. 10.1136/gut.2006.117382 18408105
15. Riggs BL Khosla S Melton LJ III A unitary model for involutional osteoprosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in ageing men J Bone Miner Res 1998, 13:763-773. 10.1359/jbmr.1998.13.5.763 9610739
16. Ettinger B Pressman A Sklarin P Bauer DC Cauley JA Cummings SR Associations between low levles of serum estradiol, bone density, and fractures among elderly women: The study of osteoporotic fractures J Clin Endocrinol Metab 1998, 83:2239-2243. 10.1210/jc.83.7.2239 9661589
17. Khosla S Melton LJ 3rd Atkinson EJ O'Fallon WM Klee GG Riggs BL Relationship of sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen J Clin Endocrinol Metab 1998, 83:2266-2274. 10.1210/jc.83.7.2266 9661593
18. Compston JE Sex Steroids and Bone Physiological reviews 2001, 81(1):419-447. 11152762
19. Clements D Compston JE Evans WD Rhodes J Hormone replacement therapy prevents bone loss in patients with inflammatory bowel disease Gut 1993, 34:1543-1546. 1374419 8244141 10.1136/gut.34.11.1543
20. Khosla S Melton LJ 3rd Riggs BL Estrogens and Bone Health in Men Calcif Tissue Int 2001, 69:189-192. 10.1007/s00223-001-1044-8 11730247
21. Khosla S Melton LJ III Riggs BL Clinical review 144: Estrogen and the male skeleton J Clin Endocrinol Metab 2002, 87:1443-1450. 10.1210/ jc.87.4.1443 11932262
22. Robinson RJ Iqbal SJ Al-Azzawi F Abrams K Meaberry JF Sex hormon status and bone metabolism in men with Crohn's disease Aliment Pharmacol Ther 1998, 12:21-25. 10.1046/j.1365-2036.1998.00271.x 9692696
23. Szathmári M Vásárhelyi B Treszl A Tulassay T Tulassay Z Association of dehydroepiandrosterone sulfate and testosterone deficiency with bone turnover in men with inflammatory bowel disease Int J Colorectal Dis 2002, 17(2):63-66. 10.1007/ s003840100334 12014422
24. Straub RH Vogl D Gross V Lang B Scholmerich J Andus T Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease Am J Gastroenterol 1998, 93:2197-2202. 10.1111/ j.1572-0241.1998.00535.x 9820396
25. de la Torre B Hedman M Befrits R Blood and tissue dehydroepiandosterone sulphate levels and their relationship to chronic inflammatory bowel disease Clin Exp Rheumatol 1998, 16:579-582. 9779307
26. Carlsen CG Soerensen TH Eriksen EF Prevalence of low serum estradiol levels in male Osteoporosis Osteoporosis Int 2000, 11(8):697-701. 11095173 10.1007/s001980070068
27. Smith EP Boyd J Frank GR Takahashi H Cohen RM Specker B Williams TC Lubahn DB Korach KS Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man N Engl J Med 1994, 331(16):1056-1061. Erratum in N Engl J Med 1995;332(2):131 10.1056/NEJM199410203311604 8090165
28. Conte FA Greenbach MM Ito Y Fisher CR Simpson ER A syndrome of female pseudohermaphroditism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom) J Clin Endocrinol Metab 1994, 78:1287-1292. 10.1210/ jc.78.6.1287 8200927
29. Morishima A Grumbach MM Simpson ER Fisher C Qin K Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogen J Clin Endocrinol Metab 1995, 80:3689-3698. 10.1210/jc.80.12.3689 8530621
30. Gillberg P Johansson AG Ljunghall S Decreased estradiol levels and free androgen index and elevated sex-hormone binding globulin levels in male idiopathic osteoporosis Calcif Tissue Int 1999, 64:209-213. 10.1007/ s002239900604 10024377
31. Pottelbergh I Goemaere S Kaufman JM Bioavailable Estradiol and an Aromatase Gene Polymorphism are Determinants of Bone Mineral Density Changes in Men over 70 Years of Age J Clin Endocrinol Metab 2003, 88:3075-3081. 10.1210/jc.2002-021691 12843146
32. Best WR Becktel JM Singleton JW Kern F Jr Development of a Crohn's disease activity index. National co-operative Crohn's disease study Gastroenterology 1976, 70:439-444. 1248701
33. WHO Study Group Assessment of fracture risk and its application to screening for postmenopausal osteoporosis World Health Organ Tech Rep Ser 1994, 843:1-129. 7941614
34. Katznelson L Fairfield WP Zeizafoun N Sands BE Peppercorn MA Rosenthal DI Klibanski A Effects of Growth Hormone Secretion on Body Composition in Patients with Crohn's Disease J Clin Endocrinol Metab 2003, 88:5468-5472. 10.1210/jc.2003-030608 14602791
35. Evans SF Davie MWJ Low body size and elevated sex-hormone binding globulin distinguish men with idiopathic vertebral fracture Calcf Tissue Int 2002, 70:09-15. 10.1007/s00223-001-2018-6
36. Slemenda CW Longcope C Zhou L Hui SL Peacock M Johnston CC Sex steroids and bone mass in older men: Positive association with serum estrogens and negative association with androgens J Clin Invest 1997, 100:1755-1759. 508359 9312174 10.1172/JCI119701
37. Rapado A Hawkins F Sobrinho L Diaz-Curiel M Galvao-Telles A Arver S Melo Gomes J Mazer N Garcia e Costa J Horcajada C Lopez Gavilanes E Mascarenhas M Papapietro K Lopez Alvarez MB Pereira MC Martinez G Valverde I Garcia JJ Carballal JJ Garcia I Bone Mineral Density and Androgen Levels in Elderly Males Calcif Tissue Int 1999, 65(6):417-421. 10.1007/s002239900726 10594158
38. Clarke BL Ebeling PR Jones JD Wahner HW O'Fallon WM Riggs BL Fitzpatrick LA Predictors of Bone Mineral Density in Aging Healthy Men Varies by Skeletal Site Calcif Tissue Int 2002 70 137 145 10.1007/ s00223-001-1072-4 11907709