Pneumococcal surface adhesin A (PsaA): A review

Critical Reviews in Microbiology

Volumn 34, Issue 3-4, 2008, Pages 131-142

  Rajam, Gowrisankar ^a   Anderton, Julie M ^a   Carlone, George M ^a   Sampson, Jacquelyn S ^a   Ades, Edwin W ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

PsaA; Streptococcus pneumoniae; Vaccine

Indexed keywords

ABC TRANSPORTER; ADHESIN; LIPOPROTEIN; PNEUMOCOCCAL SURFACE ADHESIN A; PNEUMOCOCCUS VACCINE; UNCLASSIFIED DRUG;

BACTERIAL COLONIZATION; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; CELL MEMBRANE; CRYSTAL STRUCTURE; GENE AMPLIFICATION; HUMAN; IMMUNOGENICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; X RAY CRYSTALLOGRAPHY;

ADHESINS, BACTERIAL; ANIMALS; BACTERIAL ADHESION; HUMANS; LIPOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; STREPTOCOCCAL VACCINES; STREPTOCOCCUS PNEUMONIAE; VIRULENCE FACTORS;

STREPTOCOCCUS PNEUMONIAE;

EID: 55949122952     PISSN: 1040841X     EISSN: 15497828     Source Type: Journal    
DOI: 10.1080/10408410802275352     Document Type: Review

References (119)

1. Adrian, P.V., Bogaert, D., Oprins, M., Rapola, S., Lahdenkari, M., Kilpi, T., de Groot, R., Kayhty, H., and Hermans, P. W. M. 2004. Development of antibodies against pneumococcal proteins [alpha]-enolase, immunoglobulin A1 protease, streptococcal lipoprotein rotamase A, and putative proteinase maturation protein A in relation to pneumococcal carriage and Otitis Media. Vaccine 22, 2737-2742.
2. Anderton, J.M., Rajam, G., Romero-Steiner, S., Summer, S., Kowalczyk, A.P., Carlone, G.M., Sampson, J.S., and Ades, E.W. 2007. E-cadherin is a receptor for the common protein pneumococcal surface adhesin A (PsaA) of Streptococcus pneumoniae. Microb. Pathog. 42, 225-36.
3. Audouy, S.A., van Selm, S., van Roosmalen, M.L., Post, E., Kanninga, R., Neef, J., Estevao, S., Nieuwenhuis, E. E., Adrian, P.V., Leenhouts, K., and Hermans, P. W. 2007. Development of lactococcal GEM-based pneumococcal vaccines. Vaccine 25, 2497-506.
4. Avery, O.T., and Dubos, R. 1931. The protective action of a specific enzyme against pneumococcus infection in mice. J. Exp. Med. 54, 73-89.
5. Baltimore, R.S., and Shapiro, E.D. 1991. Pneumococcal infections. In Bacterial infections of humans: epidemiology and control, ed. P.S.B.A.S. Evans, 525-546. New York: Plenum Medical.
6. Baril, L., Dietemann, J., Essevaz-Roulet, M., Beniguel, L., Coan, P., Briles, D.E., Guy, B., and Cozon, G. 2006. Pneumococcal surface protein A (PspA) is effective at eliciting T cell-mediated responses during invasive pneumococcal disease in adults. Clinical and Experimental Immunology 145, 277-286.
7. Barocchi, M.A., Censini, S., and Rappuoli, R. 2007. Vaccines in the era of genomics: the pneumococcal challenge. Vaccine 25, 2963-2973.
8. Berry, A.M., and Paton, J.C. 1996. Sequence heterogeneity of PsaA, a 37-kilodalton putative adhesin essential for virulence of Streptococcus pneumoniae. Infect. Immun. 64, 5255-5262.
9. Blau, K., Portnoi, M., Shagan, M., Kaganovich, A., Rom, S., Kafka, D., Chalifa Caspi, V., Porgador, A., Givon-Lavi, N., Gershoni, J., Dagan, R., and Mizrachi Nebenzahl, Y. 2007. Flamingo cadherin: A putative host receptor for Streptococcus pneumoniae. J. Infect. Dis. 195, 1828-1837.
10. Bogaert, D., van Belkum, A., Sluijter, M., Luijendijk, A., de Groot, R., Rumke, H.C., Verbrugh, H.A., and Hermans, P.W. 2004. Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children. Lancet 363, 1871-1872.
11. Briles, D.E., Ades, E., Paton, J.C., Sampson, J.S., Carlone, G.M., Huebner, R.C., Virolainen, A., Swiatlo, E., and Hollingshead, S.K. 2000a. Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infect. Immun. 68, 796-800.
12. Briles, D.E., Hollingshead, S., Brooks-Walter, A., Nabors, G.S., Ferguson, L., Schilling, M., Gravenstein, S., Braun, P., King, J., and Swift, A. 2000b. The potential to use PspA and other pneumococcal proteins to elicit protection against pneumococcal infection. Vaccine 18, 1707-1711.
13. Briles, D.E., Hollingshead, S.K., Paton, J.C., Ades, E.W., Novak, L., van Ginkel, F.W., and Benjamin, W.H., Jr. 2003. Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae. J. Infect. Dis. 188, 339-348.
14. Briles, D.E., Novak, L., Hotomi, M., van Ginkel, F.W., and King, J. 2005. Nasal colonization with Streptococcus pneumoniae includes subpopulations of surface and invasive pneumococci. Infect. Immun. 73, 6945-6951.
15. Bronsdon, M.A., O'Brien, K.L., Facklam, R.R., Whitney, C.G., Schwartz, B., and Carlone, G.M., 2004. Immunoblot method to detect Streptococcus pneumoniae and identify multiple serotypes from nasopharyngeal secretions. J. Clin. Microbiol. 42, 1596-1600.
16. Carvalho Mda, G., Tondella, M.L., McCaustland, K., Weidlich, L., McGee, L., Mayer, L.W., Steigerwalt, A., Whaley, M., Facklam, R.R., Fields, B., Carlone, G., Ades, E.W., Dagan, R., and Sampson, J.S. 2007. Evaluation and improvement of real-time PCR assays targeting lytA, ply, and psaA genes for detection of pneumococcal DNA. J. Clin. Microbiol. 45, 2460-2466.
17. Castaneda-Roldan, E.I., Ouahrani-Bettache, S., Saldana, Z., Avelino, F., Rendon, M.A., Dornand, J., and Giron, J.A. 2006. Characterization of SP41, a surface protein of Brucella associated with adherence and invasion of host epithelial cells. Cellular Microbiology 8, 1877-1887.
18. Cheong, Y.M., Jegathesan, M., Henrichsen, J., Wong, Y.H., Ng, A.J., and Louis, A. 1988. Antibiotic susceptibility and serotype distribution of Streptococcus pneumoniae in Malaysian children. J. Trop. Pediatr. 34, 182-185.
19. Claverys, J.P., Granadel, C., Berry, A.M., and Paton, J.C. 1999. Penicillin tolerance in Streptococcus pneumoniae, autolysis and the PsaA ATP-binding cassette (ABC) manganese permease. Mol. Microbiol. 32, 881-883.
20. Crook, J., Tharpe, J.A., Johnson, S.E., Williams, D.B., Stinson, A.R., Facklam, R.R., Ades, E.W., Carlone, G.M., and Sampson, J.S. 1998. Immunoreactivity of five monoclonal antibodies against the 37-kilodalton common cell wall protein (PsaA) of Streptococcus pneumoniae. Clin. Diagn. Lab Immunol. 5, 205-210.
21. Cundell, D.R., Weiser, J.N., Shen, J., Young, A., and Tuomanen, E.I. 1995. Relationship between colonial morphology and adherence of Streptococcus pneumoniae. Infect. Immun. 63, 757-761.
22. Cutts, F.T., Zaman, S.M.A., Enwere, G., Jaffar, S., Levine, O.S., Okoko, J.B., Oluwalana, C., Vaughan, A., Obaro, S.K., Leach, A., McAdam, K.P., Biney, E., Saaka, M., Onwuchekwa, U., Yallop, F., Pierce, N.F., Greenwood, B.M., and Adegbola, R.A. 2005. Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in the Gambia: randomised, double-blind, placebo-controlled trial. Lancet 365, 1139-1146.
23. De, B.K., Sampson, J.S., Ades, E.W., Huebner, R.C., Jue, D.L., Johnson, S.E., Espina, M., Stinson, A.R., Briles, D.E., and Carlone, G.M. 2000. Purification and characterization of Streptococcus pneumoniae palmitoylated pneumococcal surface adhesin A expressed in Escherichia coli. Vaccine 18, 1811-1821.
24. De, B.K., Sampson, J.S., Ades, E.W., Johnson, S.E., Stinson, A.R., Crook, J., Tharpe, J.A., Huebner, R.C., and Carlone, G.M. 1999. Baculovirus Expression, Purification and evaluation of recombinant pneumococcal surface adhesin A of Streptococcus pneumoniae. Pathobiology 67, 115-122.
25. Dintilhac, A., Alloing, G., Granadel, C., and Claverys, J.P. 1997. Competence and virulence of Streptococcus pneumoniae: adc and psaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases. Mol. Microbiol. 25, 727-739.
26. Faden, H., Duffy, L., Wasielewski, R., Wolf, J., Krystofik, D., Tung, Y., and Pediatrics, T.W. 1997. Relationship between nasopharyngeal colonization and the development of otitis media in children. J. Infect. Dis. 175, 1440-1445.
27. Garenne, M., C. Ronsmans., and H. Campbell. 1992. The magnitude of mortality from acute respiratory infections in children under 5 years in developing countries. World Health Stat. Q. 46, 180-191.
28. Gilson, E., Alloing, G., Schmidt, T., Claverys, J.P., Dudler, R., and Hofnung, M. 1988. Evidence for high affinity binding-protein dependent transport systems in gram-positive bacteria and in Mycoplasma. EMBO J. 7, 3971-3974.
29. Gor, D.O., Ding, X., Li, Q., Schreiber, J.R., Dubinsky, M., and Greenspan, N.S. 2002. Enhanced immunogenicity of pneumococcal surface adhesin A by genetic fusion to cytokines and evaluation of protective immunity in mice. Infect. Immun. 70, 5589-5595.
30. Gray, B.M., Converse, G.M., and Dillon, H.C. Jr. 1980. Epidemiologic studies of Streptococcus pneumoniae in infants: acquisition, carriage, and infection during the first 24 months of life. J. Infect. Dis. 142, 923-933.
31. Greenwood, B. 1999. The epidemiology of pneumococcal infection in children in the developing world. Philosophical Transactions of the Royal Society B: Biological Sciences 354, 777-785.
32. Hammerschmidt, S., Wolff, S., Hocke, A., Rosseau, S., Muller, E., and Rohde, M. 2005. Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells. Infect. Immun. 73, 4653-4667.
33. Hausdorff, W.P., Siber, G., and Paradiso, P.R. 2001. Geographical differences in invasive pneumococcal disease rates and serotype frequency in young children. The Lancet 357, 950-952.
34. Heidelberger, M., and Rebers, P.A. 1960. Immunochemistry of the pneumococcal types II, V, and VII.: The Relation of type VI to type II and other correlations between chemical constitution and precipitation in antisera to type VI. J. Bacteriol. 80, 145-153.
35. Holmlund, E., Quiambao, B., Ollgren, J., Nohynek, H., and Kayhty, H. 2006. Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage. Vaccine 24, 57-65.
36. Jakubovics, N.S., and Jenkinson, H.F. 2001. Out of the iron age: new insights into the critical role of manganese homeostasis in bacteria. Microbiology 147, 1709-1718.
37. Jedrzejas, M.J. 2001. Pneumococcal virulence factors: Structure and function. Microbiol. Mol. Biol. Rev. 65, 187-207.
38. Jenkinson, H.F. 1994. Cell surface protein receptors in oral streptococci. FEMS Microbiol. Lett. 121, 133-140.
39. Jin, Q., Yuan, Z., Xu, J., Wang, Y., Shen, Y., Lu, W., Wang, J., Liu, H., Yang, J., Yang, F., Zhang, X., Zhang, J., Yang, G., Wu, H., Qu, D., Dong, J., Sun, L., Xue, Y., Zhao, A., Gao, Y., Zhu, J., Kan, B., Ding, K., Chen, S., Cheng, H., Yao, Z., He, B., Chen, R., Ma, D., Qiang, B., Wen, Y., Hou, Y., and Yu, J. 2002. Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucl. Acids Res. 30, 4432-4441.
40. Johnson, S.E., Dykes, J.K., Jue, D.L., Sampson, J.S., Carlone, G.M., and Ades, E.W. 2002. Inhibition of pneumococcal carriage in mice by subcutaneous immunization with peptides from the common surface protein pneumococcal surface adhesin a. J. Infect. Dis. 185, 489-96.
41. Johnston, J.W., Briles, D.E., Myers, L.E., and Hollingshead, S.K. 2006. Mn2+-Dependent regulation of multiple genes in Streptococcus pneumoniae through PsaR and the resultant impact on virulence. Infect. Immun. 74, 1171-1180.
42. Johnston, J.W., Myers, L.E., Ochs, M.M., Benjamin, W.H., Jr., Briles, D.E., and Hollingshead, S.K., 2004, Lipoprotein PsaA in virulence of Streptococcus pneumoniae: surface accessibility and role in protection from superoxide. Infect. Immun. 72, 5858-5867.
43. Kamerling, J.P. 2000. Pneumococcal polysaccharides: a chemical view, In Streptococcus pneumoniae molecular biology & mechanisms of disease.A. Tomasz Mary (Ed.), 81-114. Larchmont, NY: Ann Liebert, Inc.
44. Kaplan, S.L., Mason, E.O., Jr., Wald, E.R., Schutze, G.E., Bradley, J.S., Tan, T.Q., Hoffman, J.A., Givner, L.B., Yogev, R., and Barson, W.J. 2004. Decrease of invasive pneumococcal infections in children among 8 children's hospitals in the United States after the introduction of the 7-valent pneumococcal conjugate vaccine. Pediatrics 113, 443-449.
45. Kim, J.O., and Weiser, J.N. 1998. Association of intrastrain phase variation in quantity of capsular polysaccharide and teichoic acid with the virulence of Streptococcus pneumoniae. J. Infect. Dis. 177, 368-377.
46. Klugman, K.P. 1990. Pneumococcal resistance to antibiotics, Clin. Microbiol. Rev. 3, 171-196.
47. Klugman, K.P., Madhi, S.A., Huebner, R.E., Kohberger, R., Mbelle, N., and Pierce, N. 2003. A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection. N. Engl. J. Med. 349, 1341-1348.
48. Kolenbrander, P.E., Andersen, R.N., Baker, R.A., and Jenkinson, H.F. 1998. The Adhesion-Associated sca Operon in Streptococcus gordonii encodes an inducible high-affinity ABC transporter for Mn2+ uptake. J. Bacteriol. 180, 290-295.
49. Lawrence, M.C., Pilling, P.A., Epa, V.C., Berry, A.M., Ogunniyi, A.D., and Paton, J.C. 1998. The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein. Structure 6, 1553-1561.
50. Lee, C.J., Wang, T.R., and Tai, S.S. 1997. Immunologic epitope, gene, and immunity involved in pneumococcal glycoconjugate. Crit. Rev. Microbiol. 23, 121-142.
51. Leowski, J. 1986. Mortality from acute respiratory infections in children under 5 years of age: global estimates. World Health Stat. Q. 39, 138-144.
52. Lloyd-Evans, N., O'Dempsey, T.J., Baldeh, I., Secka, O., Demba, E., Todd, J.E., McArdle, T.F., Banya, W.S., and Greenwood, B.M. 1996. Nasopharyngeal carriage of pneumococci in Gambian children and in their families. Pediatr. Infect. Dis. J. 15, 866-871.
53. McAllister, L.J., Tseng, H.J., Ogunniyi, A.D., Jennings, M.P., McEwan, A.G., and Paton, J.C. 2004. Molecular analysis of the psaA permease complex of Streptococcus pneumoniae. Mol. Microbiol. 53, 889-901.
54. McCluskey, J., Hinds, J., Husain, S., Witney, A., and Mitchell, T.J. 2004. A two-component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae. Mol. Microbiol. 51, 1661-1675.
55. Messina, A.F., Katz-Gaynor, K., Barton, T., Ahmad, N., Ghaffar, F., Rasko, D., and GH, M. 2007. Impact of the pneumococcal conjugate vaccine on serotype distribution and antimicrobial resistance of invasive Streptococcus pneumoniae isolates in Dallas, TX, children from 1999 through 2005. Pediatr. Infect. Dis. J. 26, 461-467.
56. Messmer, T.O., Sampson, J.S., Stinson, A., Wong, B., Carlone, G.M., and Facklam, R.R. 2004. Comparison of four polymerase chain reaction assays for specificity in the identification of Streptococcus pneumoniae. Diagnostic Microbiology and Infectious Disease 49, 249-254.
57. Miyaji, E.N., Dias, W.O., Gamberini, M., Gebara, V.C., Schenkman, R.P., Wild, J., Riedl, P., Reimann, J., Schirmbeck, R., and Leite, L.C. 2001. PsaA (pneumococcal surface adhesin A) and PspA (pneumococcal surface protein A) DNA vaccines induce humoral and cellular immune responses against Streptococcus pneumoniae. Vaccine 20, 805-812.
58. Morrison, K.E., Lake, D., Crook, J., Carlone, G.M., Ades, E., Facklam, R., and Sampson, J.S. 2000. Confirmation of Psaa in all 90 serotypes of Streptococcus pneumoniae by PCR and potential of this assay for identification and diagnosis. J. Clin. Microbiol. 38, 434-437.
59. Nelson, A.L., Roche, A.M., Gould, J.M., Chim, K., Ratner, A.J., and Weiser, J.N. 2007. Capsule enhances pneumococcal colonization by limiting mucus-mediated clearance. Infect. Immun. 75, 83-90.
60. Novak, R., Braun, J.S., Charpentier, E., and Tuomanen, E. 1998. Penicillin tolerance genes of Streptococcus pneumoniae: the ABC-type manganese permease complex PsaA. Mol. Microbiol. 29, 1285-1296.
61. Novak, R., Tuomanen, E., and Charpentier, E. 2000. The mystery of PsaA and penicillin tolerance in Streptococcus pneumoniae. Mol. Microbiol. 36, 1504-1505.
62. O'Brien, K.L., and Santosham, M. 2004. Potential impact of conjugate pneumococcal vaccines on pediatric pneumococcal diseases. Am. J. Epidemiol. 159, 634-644.
63. Obaro, S.K. 2000. Prospects for pneumococcal vaccination in African children. Acta Trop 75, 141-153.
64. Ogunniyi, A.D., Folland, R.L., Briles, D.E., Hollingshead, S.K., and Paton, J.C. 2000. Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae. Infect. Immun. 68, 3028-3033.
65. Ogunniyi, A.D., Giammarinaro, P., and Paton, J.C. 2002. The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology 148, 2045-2053.
66. Orihuela, C.J., Gao, G., Francis, K.P., Yu, J., and Tuomanen, E.I. 2004a. Tissue-specific contributions of pneumococcal virulence factors to pathogenesis. J. Infect. Dis. 190, 1661-1669.
67. Orihuela, C.J., Radin, J.N., Sublett, J.E., Gao, G., Kaushal, D., and Tuomanen, E.I. 2004b. Microarray analysis of pneumococcal gene expression during invasive disease. Infect. Immun. 72, 5582-5596.
68. Overweg, K., Kerr, A., Sluijter, M., Jackson, M.H., Mitchell, T.J., de Jong, A.P.J.M., de Groot, R., and Hermans, P.W.M. 2000. The putative proteinase maturation protein A of Streptococcus pneumoniae is a conserved surface protein with potential to elicit protective immune responses. Infect. Immun. 68, 4180-4188.
69. Pai, R., Moore, M.R., Pilishvili, T., Gertz, R.E., Whitney, C.G., and Beall, B. 2005. Postvaccine genetic structure of Streptococcus pneumoniae serotype 19A from children in the United States. J. Infect. Dis. 192, 1988-1995.
70. Palaniappan, R., Singh, S., Singh, U.P., Sakthivel, S.K., Ades, E.W., Briles, D.E., Hollingshead, S.K., Paton, J.C., Sampson, J.S., and Lillard, J.W. Jr. 2005. Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage. Infect. Immun. 73, 1006-1013.
71. Park, I., Pritchard, D.G., Cartee, R., Brandao, A., Brandileone, M.C., and Nahm, M.H. 2007. Discovery of a new capsular serotype (6C) within serogroup 6 of Streptococcus pneumoniae. J. Clin. Microbiol. 45, 1225-1233.
72. Parkhill, J., Wren, B.W., Mungall, K., Ketley, J.M., Churcher, C., Basham, D., Chillingworth, T., Davies, R.M., Feltwell, T., Holroyd, S., Jagels, K., Karlyshev, A.V., Moule, S., Pallen, M.J., Penn, C.W., Quail, M.A., Rajandream, M.A., Rutherford, K.M., van Vliet, A.H.M., Whitehead, S., and Barrell, B.G. 2000. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature 403, 665-668.
73. Pelton, S.I., and Klein, J.O. 1999. The promise of immunoprophylaxis for prevention of acute otitis media. Pediatr. Infect. Dis. J. 18, 926-935.
74. Pilling, P.A., Lawrence, M.C., Berry, A.M., Ogunniyi, A.D., Lock, R.A., and Paton, J.C. 1998. Expression, purification and preliminary X-ray crystallographic analysis of PsaA, a putative metal-transporter protein of Streptococcus pneumoniae. Acta Crystallogr D Biol Crystallogr 54, 1464-1466.
75. Pimenta, F.C., Miyaji, E.N., Areas, A.P., Oliveira, M.L., de Andrade, A.L., Ho, P.L., Hollingshead, S.K., and Leite, L.C. 2006. Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen A fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice. Infect. Immun. 74, 4939-4944.
76. Pracht, D., Elm, C., Gerber, J., Bergmann, S., Rohde, M., Seiler, M., Kim, K.S., Jenkinson, H.F., Nau, R., and Hammerschmidt, S. 2005. PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation. Infect. Immun. 73, 2680-2689.
77. Rajam, G., Jackson, D., Pilishvili, T., Whitney, C.G., Facklam, R.R., Carlone, G.M., and Romero-Steiner, S. 2007. An in vitro model to assess pneumococcal adherence to nasopharyngeal cells under competition conditions. J. Microbiol. Methods 70, 219-226.
78. Rajam, G., Phillips, D.J., White, E., Anderton, J., Hooper, C.W., Sampson, J.S., Carlone, G.M., Ades, E.W., and Romero-Steiner, S. 2008. A functional epitope of the pneumococcal surface adhesin A activates nasopharyngeal cells and increases bacterial internalization. Microb. Pathog. 44, 186-196.
79. Rajam, G., Romero-Steiner, S., Johnson, S.E., Thompson, T.A., Reed, Y.M., Sampson, J.S., Carlone, G.M., and Ades, E.W. 2005. Immunogenicity and functional activity of multi-antigenic peptides (MAPs) of pneumococcal surface adhesin A (PsaA) in a rabbit model. In 105th General Meeting of ASM, ASM, Atlanta, GA.
80. Rapola, S., Jantti, V., Eerola, M., Makela, P.H., Kayhty, H., and Kilpi, T. 2003. Anti-PsaA and the risk of pneumococcal AOM and carriage. Vaccine 21, 3608-3613.
81. Rapola, S., Jantti, V., Haikala, R., Syrjanen, R., Carlone, G.M., Sampson, J.S., Briles, D.E., Paton, J.C., Takala, A.K., Kilpi, T.M., and Kayhty, H. 2000. Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media. J. Infect. Dis. 182, 1146-1152.
82. Rapola, S., Kilpi, T., Lahdenkari, M., Makela, P.H., and Kayhty, H. 2001. Antibody response to the pneumococcal proteins pneumococcal surface adhesin A and pneumolysin in children with acute otitis media. Pediatr. Infect. Dis. J. 20, 482-487.
83. Read, T.D., Salzberg, S.L., Pop, M., Shumway, M., Umayam, L., Jiang, L., Holtzapple, E., Busch, J.D., Smith, K.L., Schupp, J.M., Solomon, D., Keim, P., and Fraser, C.M. 2002. Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis. Science 296, 2028-2033.
84. Reglier-Poupet, H., Pellegrini, E., Charbit, A., and Berche, P. 2003. Identification of LpeA, a PsaA-like membrane protein that promotes cell entry by Listeria monocytogenes. Infect. Immun. 71, 474-482.
85. Rigden, D.J., Galperin, M.Y., and Jedrzejas, M.J. 2003.Analysis of structure and function of putative surface-exposed proteins encoded in the Streptococcus pneumoniae genome: a bioinformatics-based approach to vaccine and drug design. Crit. Rev. Biochem. Mol. Biol. 38, 143-168.
86. Romero-Steiner, S., Caba, J., Rajam, G., Langley, T., Floyd, A., Johnson, S.E., Sampson, J.S., Carlone, G.M., and Ades, E. 2006. Adherence of recombinant pneumococcal surface adhesin A (rPsaA)-coated particles to human nasopharyngeal epithelial cells for the evaluation of anti-PsaA functional antibodies. Vaccine 24, 3224-3231.
87. Romero-Steiner, S., Pilishvili, T., Sampson, J.S., Johnson, S.E., Stinson, A., Carlone, G.M., and Ades, E.W. 2003. Inhibition of pneumococcal adherence to human nasopharyngeal epithelial cells by anti-PsaA antibodies. Clin. Diagn. Lab Immunol. 10, 246-251.
88. Rosinha, G.M.S., Freitas, D.A., Miyoshi, A., Azevedo, V., Campos, E., Cravero, S.L., Rossetti, O., Splitter, G., and Oliveira, S.C. 2002. Identification and characterization of a Brucella abortus ATP-binding cassette transporter homolog to Rhizobium meliloti ExsA and its role in virulence and protection in mice, Infect. Immun. 70, 5036-5044.
89. Russell, H., Tharpe, J.A., Wells, D.E., White, E.H., and Johnson, J.E. 1990. Monoclonal antibody recognizing a species-specific protein from Streptococcus pneumoniae. J. Clin. Microbiol. 28, 2191-2195.
90. Sa-Leao, R., Simoes, A.S., Nunes, S., Sousa, N.G., Frazao, N., and de Lencastre, H. 2006. Identification, prevalence and population structure of non-typable Streptococcus pneumoniae in carriage samples isolated from preschoolers attending day-care centres. Microbiology 152, 367-376.
91. Sampson, J.S., Furlow, Z., Whitney, A.M., Williams, D., Facklam, R., and Carlone, G.M. 1997. Limited diversity of Streptococcus pneumoniae psaA among pneumococcal vaccine serotypes. Infect. Immun. 65, 1967-1971.
92. Sampson, J.S., O'Connor, S.P., Stinson, A.R., Tharpe, J.A., and Russell, H. 1994. Cloning and nucleotide sequence analysis of psaA, the Streptococcus pneumoniae gene encoding a 37-kilodalton protein homologous to previously reported Streptococcus sp. adhesins. Infect. Immun. 62, 319-324.
93. Scott, J.A.G., Mlacha, Z., Nyiro, J., Njenga, S., Lewa, P., Obiero, J., Otieno, H., Sampson, J.S., and Carlone, G.M. 2005. Diagnosis of invasive pneumococcal disease among children in Kenya with enzyme-linked immunosorbent assay for immunoglobulin G antibodies to pneumococcal surface adhesin A. Clin. Diagn. Lab Immunol. 12, 1195-1201.
94. Seo, J.Y., Seong, S.Y., Ahn, B.Y., Kwon, I.C., Chung, H., and Jeong, S.Y. 2002. Cross-protective immunity of mice induced by oral immunization with pneumococcal surface adhesin a encapsulated in microspheres. Infect. Immun. 70, 1143-1149.
95. Simell, B., Korkeila, M., Pursiainen, H., Kilpi, T.M., and Kayhty, H. 2001. Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal surface adhesin A, pneumolysin, and pneumococcal surface protein A in children. J. Infect. Dis. 183, 887-896.
96. Singh, K.V., Coque, T.M., Weinstock, G.M., and Murray, B.E. 1998. In vivo testing of an Enterococcus faecalis efaA mutant and use of efaA homologs for species identification. FEMS Immunol. Med. Microbiol. 21, 323-331.
97. Singleton, R.J., Hennessy, T.W., Bulkow, L.R., Hammitt, L.L., Zulz, T., Hurlburt, D.A., Butler, J.C., Rudolph, K., and Parkinson, A. 2007. Invasive pneumococcal disease caused by nonvaccine serotypes among Alaska native children with high levels of 7-valent pneumococcal conjugate vaccine coverage. JAMA 297, 1784-1792.
98. Srivastava, N., Zeiler, J.L., Smithson, S.L., Carlone, G.M., Ades, E.W., Sampson, J.S., Johnson, S.E., Kieber-Emmons, T., and Westerink, M.A. 2000. Selection of an immunogenic and protective epitope of the PsaA protein of Streptococcus pneumoniae using a phage display library. Hybridoma 19, 23-31.
99. Standish, A.J., Stroeher, U.H., and Paton, J.C. 2007. Pneumococcal two-component signal transduction system RR/HK06 regulates CbpA and PspA by two distinct mechanisms. J. Bacteriol 189, 5591-5600.
100. Swiatlo, E., King, J., Nabors, G.S., Mathews, B., and Briles, D.E. 2003. Pneumococcal surface protein A is expressed in vivo, and antibodies to PspA are effective for therapy in a murine model of pneumococcal sepsis. Infect. Immun. 71, 7149-7153.
101. Swiatlo, E., and Ware, D. 2003. Novel vaccine strategies with protein antigens of Streptococcus pneumoniae. FEMS Immunol. Med. Microbiol. 38, 1-7.
102. Tai, S.S. 2006. Streptococcus pneumoniae protein vaccine candidates: properties, activities and animal studies. Crit. Rev. Microbiol. 32, 139-153.
103. Tam, R., and Saier, M.H. Jr. 1993. Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria. Microbiol Rev 57, 320-346.
104. Tharpe, J.A., and Russell, H. 1996. Purification and seroreactivity of pneumococcal surface adhesin A (PsaA). Clin. Diagn. Lab Immunol. 3, 227-229.
105. Tharpe, J.A., Russell, H., Leinonen, M., Plikaytis, B.D., Breiman, R.F., Carlone, G.M., Ades, E.W., and Sampson, J.S. 1998. Comparison of a pneumococcal common protein (PsaA) antibody ELISA and a PsaA immune complex ELISA for detection of pneumococcal serum antibody. Pathobiology 66, 77-83.
106. Tseng, H.J., McEwan, A.G., Paton, J.C., and Jennings, M.P. 2002. Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress, Infect. Immun. 70, 635-639.
107. Verhelst, R., Kaijalainen, T., De Baere, T., Verschraegen, G., Claeys, G., Van Simaey, L., De Ganck, C., and Vaneechoutte, M. 2003. Comparison of five genotypic techniques for identification of optochin-resistant pneumococcus-like isolates. J. Clin. Microbiol. 41, 3521-3525.
108. Wang, E. 2003. Development of the Aventis Pasteur pneumococcal protein vaccine, In National Vaccine Advisory Committee (ed) M. Steinhoff, Washington, DC. http://www.hhs.gov/nvpo/nvac/index.html
109. Weiser, J.N., Austrian, R., Sreenivasan, P.K., and Masure, H.R. 1994. Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonization. Infect. Immun. 62, 2582-2589.
110. Weiser, J.N., Bae, D., Epino, H., Gordon, S.B., Kapoor, M., Zenewicz, L.A., and Shchepetov, M. 2001. Changes in availability of oxygen accentuate differences in capsular polysaccharide expression by phenotypic variants and clinical isolates of Streptococcus pneumoniae. Infect. Immun. 69, 5430-5439.
111. Weiser, J.N., Bae, D., Fasching, C., Scamurra, R.W., Ratner, A.J., and Janoff, E.N. 2003. Antibody-enhanced pneumococcal adherence requires IgA1 protease. PNAS 100, 4215-4220.
112. Weiser, J.N., Markiewicz, Z., Tuomanen, E.I., and Wani, J.H. 1996. Relationship between phase variation in colony morphology, intrastrain variation in cell wall physiology, and nasopharyngeal colonization by Streptococcus pneumoniae. Infect. Immun. 64, 2240-2245.
113. Whaley, M.J., Rajam, G.; Parks, A.S., Holder, P., Mauro, E., Carlone, G., Steiner, S., Sampson, J., and Ades, E. 2006. A combination vaccine of recombinant PsaA and PCV7 reduces Streptococcus pneumoniae non-vaccine serotype colonization in a murine model, In International Conference on Emerging Infectious Diseases, American Society for Microbiology, Atlanta, GA.
114. Whitney, C.G., Farley, M.M., Hadler, J., Harrison, L.H., Bennett, N.M., Lynfield, R., Reingold, A., Cieslak, P.R., Pilishvili, T., Jackson, D., Facklam, R.R., Jorgensen, J.H., and Schuchat, A. 2003. Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. N. Engl. J. Med. 348, 1737-1746.
115. WHO, 1997. Global programme for vaccines and immunization (vaccine research and development). Report of The Technical Review Group meeting, In Achievements and plan of activities: meningococcal and pneumococcal disease vaccines, 26-30. Geneva, Switzerland: World Health Organization.
116. Yu, X., Gray, B., Chang, S., Ward, J.I., Edwards, K.M., and Nahm, M.H. 1999. Immunity to cross-reactive serotypes induced by pneumococcal conjugate vaccines in infants. J. Infect. Dis. 180, 1569-1576.
117. Zenni, M.K., Cheatham, S.H., Thompson, J.M., Reed, G.W., Batson, A.B., Palmer, P.S., Holland, K.L., and Edwards, K.M. 1995. Streptococcus pneumoniae colonization in the young child: association with otitis media and resistance to penicillin. J. Pediatr. 127, 533-537.
118. Zhang, Q., Bernatoniene, J., Bagrade, L., Pollard, A.J., Mitchell, T.J., Paton, J.C., and Finn, A. 2006. Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status. Eur. J. Immunol. 36, 46-57.
119. Zhang, Q., Choo, S., and Finn, A. 2002. Immune responses to novel pneumococcal proteins pneumolysin, PspA, PsaA, and CbpA in adenoidal B cells from children. Infect. Immun. 70, 5363-5369.