Lack of evidence for oxidative stress in sporadic amyotrophic lateral sclerosis fibroblasts

Neurodegenerative Diseases

Volumn 6, Issue 1-2, 2008, Pages 9-15

  Sala, Gessica ^a   Trombin, Federica ^a   Mattavelli, Laura ^a,b   Beretta, Simone ^a,b   Tremolizzo, Lucio ^a,b   Andreoni, Simona ^a   Calabrese, Elena ^c   Sanvito, Lara ^c   Ferrarese, Carlo ^a,b,d  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c Fondazione IRCSS Santa Maria Nascente Don Gnocchi   (Italy)

^d SCIENTIFIC INSTITUTE   (Italy)

Author keywords

Amyotrophic lateral sclerosis; Fibroblasts; p38 mitogen activated protein kinase; Protein carbonylation; Protein nitration; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BIOENERGY; CELL STRESS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; FEMALE; FIBROBLAST; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MALE; NITRATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION;

ADENOSINE TRIPHOSPHATE; AGED; AMYOTROPHIC LATERAL SCLEROSIS; CELL SURVIVAL; CELLS, CULTURED; FEMALE; FIBROBLASTS; FLUORESCEINS; HUMANS; MALE; MIDDLE AGED; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REFERENCE VALUES;

EID: 55949115988     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000121390     Document Type: Article

References (27)

1. Ferrante RJ, Browne SE, Shinobu LA, Bowling AC, Baik MJ, MacGarvey U, Kowall NW, Brown RH Jr, Beal MF: Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem 1997;69:2064-2074.
2. Niebroj-Dobosz I, Dziewulska D, Kwiecinski H: Oxidative damage to proteins in the spinal cord in amyotrophic lateral sclerosis (ALS). Folia Neuropathol 2004;42:151-156.
3. Shaw PJ, Forrest V, Ince PG, Richardson JP, Wastell HJ: CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients. Neurodegeneration 1995;4:209-216.
4. Smith RG, Henry YK, Mattson MP, Appel SH: Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis. Ann Neurol 1998;44:696-699.
5. Tohgi H, Abe T, Yamazaki K, Murata T, Ishizaki E, Isobe C: Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis. Ann Neurol 1999;46:129-131.
6. Ryberg H, Soderling AS, Davidsson P, Blennow K, Caidahl K, Persson LI: Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease. Neurochem Int 2004;45:57-62.
7. Simpson EP, Henry YK, Henkel JS, Smith RG, Appel SH: Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden. Neurology 2004;62:1758-1765.
8. Bogdanov M, Brown RH, Matson W, Smart R, Hayden D, O'Donnell H, Beal MF, Cudkowicz M: Increased oxidative damage to DNA in ALS patients. Free Radic Biol Med 2000;29:652-658.
9. Ihara Y, Mori A, Hayabara T, Kawai M, Namba R, Nobukuni K, Sato K, Kibata M: Superoxide dismutase and free radicals in sporadic amyotrophic lateral sclerosis: relationship to clinical data. J Neurol Sci 1995;134:51-56.
10. Bonnefont-Rousselot D, Lacomblez L, Jaudon M, Lepage S, Salachas F, Bensimon G, Bizard C, Doppler V, Delattre J, Meininger V: Blood oxidative stress in amyotrophic lateral sclerosis. J Neurol Sci 2000;178:57-62.
11. Oteiza PI, Uchitel OD, Carrasquedo F, Dubrovski AL, Roma JC, Fraga CG: Evaluation of antioxidants, protein, and lipid oxidation products in blood from sporadic amyotrophic lateral sclerosis patients. Neurochem Res 1997;22:535-539.
12. Ferri A, Nencini M, Battistini S, Giannini F, Siciliano G, Casali C, Damiano MG, Ceroni M, Chiò A, Rotilio G, Carrì MT: Activity of protein phosphatase calcineurin is decreased in sporadic and familial amyotrophic lateral sclerosis patients. J Neurochem 2004;90:1237-1242.
13. Jansen GA, Wanders RJ, Jobsis GJ, Bolhuis PA, de Jong JM: Evidence against increased oxidative stress in fibroblasts from patients with non-superoxide-dismutase-1 mutant familial amyotrophic lateral sclerosis. J Neurol Sci 1996;139:91-94.
14. Aguirre T, Van den Bosch L, Goetschalckx K, Tilkin P, Mathijs G, Cassiman JJ, Robberecht W: Increased sensitivity of fibroblasts from amyotrophic lateral sclerosis patients to oxidative stress. Ann Neurol 1998;43:452-457.
15. Begni B, Brighina L, Fumagalli L, Andreoni S, Castelli E, Francesconi C, Del Bo R, Bresolin N, Ferrarese C: Altered glutamate uptake in peripheral tissues from Down syndrome patients. Neurosci Lett 2003;343:73-76.
16. Balabanli B, Kamisaki Y, Martin E, Murad F: Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine. Proc Natl Acad Sci USA 1999;96:13136-13141.
17. Aulak KS, Koeck T, Crabb JW, Stuehr DJ: Proteomic method for identification of tyrosine-nitrated proteins. Methods Mol Biol 2004;279:151-165.
18. Koeck T, Fu X, Hazen SL, Crabb JW, Stuehr DJ, Aulak KS: Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria. J Biol Chem 2004;279:27257-27262.
19. Kamisaki Y, Wada K, Bian K, Balabanli B, Davis K, Martin E, Behbod F, Lee YC, Murad F: An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc Natl Acad Sci USA 1998;95:11584-11589.
20. Horstmann S, Kahle PJ, Borasio GD: Inhibitors of p38 mitogen-activated protein kinase promote neuronal survival in vitro. J Neurosci Res 1998;52:483-490.
21. Skaper SD, Walsh FS: Neurotrophic molecules: strategies for designing effective therapeutic molecules in neurodegeneration. Mol Cell Neurosci 1998;12:179-193.
22. Zhu X, Rottkamp CA, Boux H, Takeda A, Perry G, Smith MA: Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol 2000;59:880-888.
23. Tortarolo M, Veglianese P, Calvaresi N, Botturi A, Rossi C, Giorgini A, Migheli A, Bendotti C: Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression. Mol Cell Neurosci 2003;23:180-192.
24. Bendotti C, Atzori C, Piva R, Tortarolo M, Strong MJ, DeBiasi S, Migheli A: Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice. J Neuropathol Exp Neurol 2004;63:113-119.
25. Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS, Anderton BH, Cooper JD, Dingwall C, Leigh PN, Shaw CE, Miller CC: p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis. Mol Cell Neurosci 2004;26:354-364.
26. Begni B, Brighina L, Sirtori E, Fumagalli L, Andreoni S, Beretta S, Oster T, Malaplate-Armand C, Isella V, Appollonio I, Ferrarese C: Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease. Free Radic Biol Med 2004;37:892-901.
27. Gasparini L, Benussi L, Bianchetti A, Binetti G, Curti D, Govoni S, Moraschi S, Racchi M, Trabucchi M: Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts. Neurosci Lett 1999;263:197-200.