Heart and tumors: Location, metastasis, clinical manifestations, diagnostic approaches and therapeutic considerations

Journal of Cardiovascular Medicine

Volumn 9, Issue 8, 2008, Pages 769-777

  Ekmektzoglou, Konstantinos A ^a,c   Samelis, Georgios F ^b   Xanthos, Theodoros ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b KAT HOSPITAL   (Greece)

^c NONE   (Greece)

Author keywords

Cardiac tumors; Diagnosis; Heart neoplasms; Symptoms; Therapy

Indexed keywords

CISPLATIN; THIOTEPA;

ANEMIA; ANGIOGRAPHY; ANGIOSARCOMA; AORTA VALVE; ARTHRALGIA; ARTICLE; ARTIFICIAL EMBOLISM; BENIGN TUMOR; BLOOD VESSEL OCCLUSION; BREAST TUMOR; CANCER ADJUVANT THERAPY; CANCER DIAGNOSIS; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CARDIOMEGALY; COMPLETE HEART BLOCK; COMPUTER ASSISTED TOMOGRAPHY; CONGESTIVE HEART FAILURE; COUGHING; CYANOSIS; CYTOLOGY; CYTOMETRY; DISEASE PREDISPOSITION; DYSPNEA; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ENDOCARDIUM; EPICARDIUM; ESOPHAGUS TUMOR; FEVER; FIBROELASTOMA; HEART ARRHYTHMIA; HEART ATRIUM SEPTUM; HEART FAILURE; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HEART METASTASIS; HEART MUSCLE; HEART MUSCLE BIOPSY; HEART MYXOMA; HEART PALPITATION; HEART RIGHT ATRIUM; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE FAILURE; HEART SARCOMA; HEART TAMPONADE; HEART TRANSPLANTATION; HEART TUMOR; HEART VALVE STENOSIS; HEART VENTRICLE SEPTUM; HEART VENTRICLE TACHYCARDIA; HEMANGIOMA; HEMOPERICARDIUM; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; LEUKEMIA; LEUKOCYTOSIS; LIVER; LUNG CANCER; LUNG EMBOLISM; LYMPHOMA; MALAISE; MESOTHELIOMA; MITRAL VALVE; MYALGIA; NUCLEAR MAGNETIC RESONANCE IMAGING; ORTHOTOPIC TRANSPLANTATION; OSTEOSARCOMA; PANCREAS TUMOR; PAPILLOMA; PAROXYSMAL DYSPNEA; PERICARDIAL EFFUSION; PERICARDIOCENTESIS; PERIPHERAL EDEMA; PRIMARY TUMOR; RESPIRATORY TRACT DISEASE; RHABDOMYOMA; RHABDOMYOSARCOMA; SCLEROTHERAPY; SEDIMENTATION RATE; STOMACH TUMOR; STROKE; SUDDEN DEATH; SYNCOPE; TACHYCARDIA; THORAX PAIN; THORAX RADIOGRAPHY; TUMOR CLASSIFICATION; TUMOR LOCALIZATION; TUMOR VOLUME; VALVULAR HEART DISEASE; WEIGHT REDUCTION; DIAGNOSTIC IMAGING; DIFFERENTIAL DIAGNOSIS; HEART SURGERY; METASTASIS; METHODOLOGY; PROGNOSIS; REVIEW;

CARDIAC SURGICAL PROCEDURES; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC IMAGING; HEART NEOPLASMS; HUMANS; NEOPLASM METASTASIS; PROGNOSIS;

EID: 55949110361     PISSN: 15582027     EISSN: None     Source Type: Journal    
DOI: 10.2459/JCM.0b013e3282f88e49     Document Type: Article

References (80)

1. Reynen K. Frequency of primary tumors of the heart. Am J Cardiol 1996; 77:107.
2. Lam KY, Dickens P, Chan AC. Tumors of the heart. A 20-year experience with a review of 12485 consecutive autopsies. Arch Pathol Lab Med 1993; 117:1027-1031.
3. Vander Salm TJ. Unusual primary tumors of the heart. Semin Thorac Cardiovasc Surg 2000; 12:89-100.
4. Burke AP, Cowan D, Virmani R. Primary sarcomas of the heart. Cancer 1992; 69:387-395.
5. Odim J, Reehal V, Laks H, Mehta U, Fishbein MC. Surgical pathology of cardiac tumors. Two decades at an urban institution. Cardiovasc Pathol 2003; 12:267-270.
6. Putnam J, Sweeney M, Colon R, Lanza LA, Frazier OH, Cooley DA. Primary cardiac sarcomas. Ann Thorac Surg 1991; 51:906-910.
7. Araoz PA, Mulvagh SL, Tazelaar HD, Julsrud PR, Breen JF. CT and MR imaging of benign primary cardiac neoplasms with echocardiographic correlation. RadioGraphics 2000; 20:1303-1319.
8. Villalpando-Mendoza E, Perez-Perez FM, Cortes-Flores AO, Velazquez-Ramirez GA, Fuentes-Orozco C, Gonzalez-Ojeda A. Frequency of heart tumors and their histopathological correlation. Cir Cir 2006; 74:183-187.
9. Kisselbach C, Ristic AD, Pankuweit S, Karatolius K, Maisch B. Women and pericardial neoplastic manifestations of the heart and pericardium. Herz 2005; 30:409-415.
10. Sarjeant JM, Butany J,Cusimano RJ. Cancer of the heart: epidemiology and management of primary tumors and metastases. Am J Cardiovasc Drugs 2003; 3:407-421.
11. Petropoulakis PN, Steriotis JD, Melanidis JG, Asimakopoulos PJ. Metastatic malignant melanoma as an intracavitary obstructive mass in the right heart. Eur J Cardiothorac Surg 1998; 14:538-540.
12. Butany J, Nair V, Naseemuddin A, Nair GM, Catton C, Yau T. Cardiac tumours: diagnosis and management. Lancet Oncol 2005; 6:219-228.
13. Roberts WC. Neoplasms involving the heart, their simulators, and adverse consequences of their therapy. Proc (Bayl Univ Med Cent) 2001; 14:358-376.
14. Debourdeau P, Gligorov J, Teixeira L, Aletti M, Zammit C. Malignant cardiac tumors. Bull Cancer 2004; 91 (Suppl 3):136-146.
15. Perchinsky MJ, Lichtenstein SV, Tyers GF. Primary cardiac tumors: 40 years' experience with 71 patients. Cancer 1997; 79:1809-1815.
16. Grande AM, Ragni T, Vigano M. Primary cardiac tumors. A clinical experience of 12 years. Tex Heart Inst J 1993; 20:223-230.
17. Roberts WC. Primary and secondary neoplasms of the heart. Am J Cardiol 1997; 80:671-682.
18. Massie BM, Amidon TM. Neoplastic diseases of the heart. In: Tierny LM, McPhee SJ, Papadakis MA, editors. Current medical diagnosis and treatment, 39th ed. New York: Lange; 2000. p. 438.
19. Colluci WS, Schoen FJ. Primary tumors of the heart. In: Braunwald E, Zipes DP, Libby P, editors. Heart disease, 6th ed. Philadelphia, PA: WB Saunders; 2001. pp. 1807-1819.
20. Otto CM. Textbook of clinical echocardiography. 2nd ed. Philadelphia, PA: WB Saunders; 2000. pp. 350-370.
21. Spodick DH. Neoplastic pericardial disease. In: Spodick DH, editor. The pericardium: a comprehensive textbook. New York: Marcel Dekker; 1997. pp. 301-313.
22. Carney JA, Hruska LS, Beauchamp GD, GordonH.Dominant inheritance of the complex of myxomas, spotty pigmentation and endocrine overactivity. Mayo Clin Proc 1986; 61:165-172.
23. Stergiopoulos SG, Stratakis CA. Human neoplasms associated with Carney complex and germline PRKAR1A mutations: a protein kinase A disease. FEBS Lett 2003; 546:59-64.
24. Webb DW, Thomas RD, Osborne JP. Cardiac rhabdomyomas and their association with tuberous sclerosis. Arch Dis Child 1993; 68:367-370.
25. Geipel A, Krapp M, Germer U, Becker R, Gembruch U. Perinatal diagnosis of cardiac tumors. Ultrasound Obstet Gynecol 2001; 17:17-21.
26. Pipitone S, Mongiovi M, Grillo R, Gagliano S, Sperandeo V. Cardiac rhabdomyoma in intrauterine life: clinical features and natural history. A case series and review of published reports. Ital Heart J 2002; 3:48-52.
27. Jones KL, Wolf PL, Jensen P, Dittrich H, Benirschke K, Bloor C. The Gorlin syndrome: a genetically determined disorder associated with cardiac tumor. Am Heart J 1986; 111:1013-1015.
28. Roberts WC, Glancy DL, DeVita VT Jr. Heart in malignant lymphoma (Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma and mycosis fungoides). A study of 196 autopsy cases. Am J Cardiol 1968; 22:85-107.
29. Lestuzzi C, Nicolosi GL, Biasi S, Piotti P, Zanuttini D. Sensitivity and specificity of electrocardiographic ST-T changes as markers of neoplastic myocardial infiltration. Echocardiographic correlation. Chest 1989; 95:980-985.
30. Shiono J, Horigome H, Yasui S, Miyamoto T, Takahashi-Igari M, Iwasaki N, et al. Electrocardiographic changes in patients with cardiac rhabdomyomas associated with tuberous sclerosis. Cardiol Young 2003; 13:258-263.
31. Smith DN, Shaffer K, Patz EF. Imaging features of nonmyxomatous primary neoplasms of the heart and pericardium. Clin Imaging 1998; 22:15-22.
32. Abrams HL, Adams DF, Grant HA. The radiology of tumors of the heart. Radiol Clin North Am 1971; 9:299-326.
33. Davis GD, Kincaid OW, Hallermann FJ. Roentgen aspects of cardiac tumors. Semin Roentgenol 1969; 4:384-394.
34. Meng Q, Lai H, Lima J, Tong W, Qian Y, Lai S. Echocardiographic and pathologic characteristics of primary cardiac tumors: a study of 149 cases. Int J Cardiol 2002; 84:69-75.
35. Alam M, Rosman HS, Grullon C. Transesophageal echocardiography in evaluation of atrial masses. Angiology 1995; 46:123-128.
36. Matsumura M, Takamoto S, Kyo S, Yokote Y, Omoto R. Advantages of transesophageal color Doppler echocardiography in the diagnosis and surgical treatment of cardiac masses. J Cardiol 1990; 20:701-714.
37. Goldman JH, Foster E. Transesophageal echocardiographic (TEE) evaluation of intracardiac and pericardial masses. Cardiol Clin 2000; 18:849-860.
38. Leibowitz G, Keller NM, Daniel WG, Freedberg RS, Tunick PA, Stottmeister C, et al. Transesophageal versus transthoracic echocardiography in the evaluation of right atrial tumors. Am Heart J 1995; 130:1224-1227.
39. Vieira ML, Ianni BM, Mady C, Encinas J, Pommmerantzeff PM, Fernandes PP, et al. Left atrial myxoma: three-dimensional echocardiographic assessment. Arq Bras Cardiol 2004; 82:281-283.
40. Harada T, Ohtaki E, Suniyoshi T, Hosoda S. Successful three-dimensional reconstruction using transesophageal echocardiography in a patient with a left atrial myxoma. Jpn Heart J 2001; 42:789-792.
41. Handke M, Schochlin A, Schafer DN, Beyersdorf F, Geibel A. Myxoma of the mitral valve: diagnosis by 2-dimensional and 3-dimensional echocardiography. J Am Soc Echocardiogr 1999; 12:773-776.
42. Chaloupka JC, Fishman EK, Siegelman SS. Use of CT in the evaluation of primary cardiac tumors. Cardiovasc Intervent Radiol 1986; 9:132-135.
43. Dawson WB, Mayo JR, Müller NL. Computed tomography of cardiac and pericardial tumors. J Can Assoc Radiol 1990; 41:270-275.
44. Gross BH, Glazer GM, Francis IR. CT of intracardiac and intrapericardial masses. AJR Am J Roentgenol 1983; 140:903-907.
45. Winkler M, Higgins CB. Suspected intracardiac masses: evaluation with MR imaging. Radiology 1987; 165:117-122.
46. Lund JT, Ehman RL, Julsrud PR, Sinak LJ, Tajik AJ. Cardiac masses: assessment by MR imaging. AJR Am J Roentgenol 1989; 152:469-473.
47. Spuentrup E, Mahnken AH, Kuhl HP, Krombach GA, Botnar RM, Wall A, et al. Fast interactive real-time magnetic resonance imaging of cardiac masses using spiral gradient echo and radial steady-state free precession sequences. Invest Radiol 2003; 38:288-292.
48. Spuentrup E, Kuehl HP, Wall A, Heer C, Buecker A. Visualization of cardiac myxoma mobility with real-time spiral magnetic resonance imaging. Circulation 2001; 104:E101.
49. Amparo EG, Higgins CB, Farmer D, Gamsu G, McNamara M. Gated MRI of cardiac and paracardiac masses: initial experience. AJR Am J Roentgenol 1984; 143:1151-1156.
50. Funari M, Fujita N, Peck WW, Higgins CB. Cardiac tumors: assessment with Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr 1991; 15:953-958.
51. Kaminaga T, Takeshita T, Kimura I. Role of magnetic resonance imaging for evaluation of tumors in the cardiac region. Eur Radiol 2003; 13 (Suppl 4):L1-L10.
52. Menegus MA, Greenberg MA, Spindola-Franco H, Fayemi A. Magnetic resonance imaging of suspected atrial tumors. Am Heart J 1992; 123:1260-1268.
53. Gulati G, Sharma S, Kothari SS, Juneja R, Saxena A, Talwar KK. Comparison of echo and MRI in the imaging evaluation of intracardiac masses. Cardiovasc Intervent Radiol 2004; 27:459-469.
54. Restrepo CS, Largoza A, Lemos DF, Diethelm L, Koshy P, Patricia Castillo P, et al. CT and MR imaging findings of benign cardiac tumors. Curr Probl Diagn Radiol 2005; 34:12-21.
55. Chow WH, Chow TC, Tai YT, Yip AS, Cheung KL. Angiographic visualization of 'tumour vascularity' in atrial myxoma. Eur Heart J 1991; 12:79-82.
56. Yamamoto K, Bando S, Shinohara A, Ikefuji H, Nishikado A, Hamai K, et al. Right atrial myxoma with hypervascularity demonstrated by selective coronary angiography. Tokushima J Exp Med 1991; 38:91-97.
57. Basso C, Valente M, Poletti A, Casarotto D, Thiene G. Surgical pathology of primary cardiac and pericardial tumors. Eur J Cardiothorac Surg 1997; 12:730-737; [discussion 737-738].
58. Szturmowicz M, Tomkowski W, Fijalkowska A, Filipecki S. The role of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) evaluation in pericardial fluid for the recognition of malignant pericarditis. Int J Biol Markers 1997; 12:96-101.
59. Dein JR, Frist WH, Stinson EB, Miller DC, Baldwin JC, Oyer PE, et al. Primary cardiac neoplasms: early and late results of surgical treatment in 42 patients. J Thorac Cardiovasc Surg 1987; 93:502-511.
60. Larrieu AJ, Jamieson WR, Tyers GF, Burr LH, Munro AI, Miyagishima RT, et al. Primary cardiac tumors: experience with 25 cases. J Thorac Cardiovasc Surg 1982; 83:339-348.
61. Waller DA, Ettles DF, Saunders NR, Williams G. Recurrent cardiac myxoma: the surgical implications of two distinct groups of patients. J Thorac Cardiovasc Surg 1989; 37 :226-230.
62. Michler RE, Goldstein DJ. Treatment of cardiac tusmors by orthotopic cardiac transplantation. Semin Oncol 1997; 34:534-539.
63. Goldstein DJ, OzMC, Rose EA, Fisher P, Michler RE. Experience with heart transplantation for cardiac tumors. J Heart Lung Transplant 1995; 14:382-386.
64. Reece IJ, Cooley DA, Frazier OH, Hallman GL, Powers PL, Montero CG. Cardiac tumors: clinical spectrum and prognosis of lesions other than classical benign myxoma in 20 patients. J Thorac Cardiovasc Surg 1984; 88:439-446.
65. Miralless A, Bracamonte L, Soncul H, Diaz del Castillo R, Akhtar R, Bors V, et al. Cardiac tumors: clinical experience and surgical results in 74 patients. Ann Thorac Surg 1991; 53:886-895.
66. Rossi NP, Kioschos JM, Aschenbrener CA, Ehrenhaft JL. Primary angiosarcoma of the heart. Cancer 1976; 37:891-894.
67. Sorlie D, Myhre ESP, Stalsberg H. Angiosarcoma of the heart: unusual presentation and survival after treatment. Br Heart J 1984; 51:94-97.
68. Centofanti P, Di Rosa E, Deorsola L, Dato GM, Patane F, La Torre M, et al. Primary cardiac tumors: early and late results of surgical treatment in 91 patients. Ann Thorac Surg 1999; 68:1236-1241.
69. Reardon MJ, Walkes JC, Benjamin R. Therapy Insight: malignant primary cardiac tumors. Nat Clin Pract Cardiovasc Med 2006; 3:548-553.
70. Bishiniotis TS, Antoniadou S, Katseas G, Mouratidou D, Litos AG, Balamoutsos N. Malignant cardiac tamponade in women with breast cancer treated by pericardiocentesis and intrapericardial administration of triethylenethiophosphoramide (thiotepa). Am J Cardiol 2000; 86:362-364.
71. Tomkowski WZ, Wisniewska J, Szturmowicz M, Kuca P, Burakowski J, Kober J, et al. Evaluation of intrapericardial cisplatin administration in cases with recurrent malignant pericardial effusion and cardiac tamponade. Support Care Cancer 2004; 12:53-57.
72. Maisch B, Ristic AD, Pankuweit S, Neubauer A, Moll R. Neoplastic pericardial effusion: efficacy and safety of intrapericardial treatment with cisplatin. Eur Heart J 2002; 23:1625-1631.
73. Hancock EW. Neoplastic pericardial disease. Cardiol Clin 1990; 8:673-682.
74. Vaitkus PT, Herrmann HC, LeWinter MM. Treatment of malignant pericardial effusion. JAMA 1994; 272:59-64.
75. Spodick DH. Pericardial diseases. In: Braunwald E, Zipes DP, Libby P, editors. Heart disease, 6th ed. Philadelphia: W.B. Saunders; 2001. pp. 1858-1859.
76. Maher EA, Shepherd FA, Todd TJ. Pericardial sclerosis as the primary management of malignant pericardial effusion and cardiac tamponade. J Thorac Cardiovasc Surg 1996; 112:637-643.
77. Martinoni A. Treatment of neoplastic pericardial effusions. Recent Prog Med 2006; 97:206-210.
78. Martinoni A, Cipolla CM, Civelli M, Cardinale D, Lamantia G, Colleoni M, et al. Intrapericardial treatment of neoplastic pericardial effusions. Herz 2000; 25:787-793.
79. Gowdamarajan A, Michler RE. Therapy for primary cardiac tumors: is there a role for heart transplantation? Curr Opin Cardiol 2000; 15:121-125.
80. Reardon MJ, Malaisrie SC, Walkes JC, Vaporciyan AA, Rice DC, Smythe WR, et al. Cardiac autotransplantation for primary cardiac tumors. Ann Thorac Surg 2006; 82:645-650.