Optimization of 5-aryloxyimidazole non-nucleoside reverse transcriptase inhibitors

ChemMedChem

Volumn 3, Issue 11, 2008, Pages 1756-1762

  Jones, Lyn H ^a   Allan, Gill ^a   Corbau, Romuald ^a   Hay, Duncan ^a   Middleton, Donald S ^a   Mowbray, Charles E ^a   Newman, Sandra D ^a   Perros, Manos ^a   Randall, Amy ^a   Vuong, Hannah ^a   Webster, Rob ^a   Westby, Mike ^a   Williams, David ^a  

^a PFIZER INC   (United States)

Author keywords

AIDS; Antiviral agents; Aryloxy imidazole; Medicinal chemistry; NNRTI

Indexed keywords

ANTIVIRUS AGENT; CAPRAVIRINE; IMIDAZOLE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SULFUR DERIVATIVE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL RESISTANCE; ARTICLE; BINDING SITE; CELL LINE; CHEMICAL MODEL; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; HUMAN; IC 50; METHODOLOGY; MUTATION; SYNTHESIS;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ALLOSTERIC SITE; ANTIVIRAL AGENTS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG RESISTANCE, VIRAL; HIV REVERSE TRANSCRIPTASE; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS; SULFUR COMPOUNDS;

EID: 55949106137     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800183     Document Type: Article

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