Long-term safety and efficacy of zonisamide in patients with refractory partial-onset epilepsy

Acta Neurologica Scandinavica

Volumn 118, Issue 2, 2008, Pages 87-93

  Wroe, S J ^a   Yeates, A B ^b   Marshall, A ^b  

^a NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^b EISAI CO LTD   (Japan)

Author keywords

Efficacy; Epilepsy; Partial; Refractory; Safety; Zonisamide

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; VALPROIC ACID; ZONISAMIDE; ISOXAZOLE DERIVATIVE;

ADD ON THERAPY; APPETITE; ARTICLE; ATTENTION DISTURBANCE; CHOLELITHIASIS; CLINICAL EVALUATION; CLINICAL PRACTICE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVULSION; COORDINATION; DIARRHEA; DISEASE ASSOCIATION; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EPILEPSY; EPILEPTIC STATE; FALLING; FATIGUE; FOCAL EPILEPSY; HEAD INJURY; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; NAUSEA; PATIENT COMPLIANCE; PNEUMONIA; PREDICTION; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SEIZURE; SIDE EFFECT; SINGLE DRUG DOSE; SOMNOLENCE; SUICIDE ATTEMPT; UNPLANNED PREGNANCY; WEIGHT REDUCTION; DOSE RESPONSE; DRUG RESISTANCE; LONGITUDINAL STUDY; SAFETY; TIME; TREATMENT OUTCOME;

ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; EPILEPSIES, PARTIAL; HUMANS; ISOXAZOLES; LONGITUDINAL STUDIES; SAFETY; TIME FACTORS; TREATMENT OUTCOME;

EID: 55949103811     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2008.01055.x     Document Type: Article

References (16)

1. SEMAH F, PICOT MC, ADAM C et al. Is the underlying cause of epilepsy a major prognostic factor for recurrence? Neurology 1998;51:1256-62.
2. BAULAC M. Introduction to zonisamide. Epilepsy Res 2006;68(Suppl. 2):S3-9.
3. SCHMIDT D, JACOB R, LOISEAU P et al. Zonisamide for addon treatment of refractory partial epilepsy: a European double-blind trial. Epilepsy Res 1993;15:67-73.
4. FAUGHT E, AYALA R, MONTOURIS GG, LEPPIK IE. Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures. Neurology 2001;57:1774-9.
5. SACKELLARES JC, RAMSAY RE, WILDER BJ, BROWNE TR III, SHELLENBERGER MK. Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures. Epilepsia 2004;45:610-7.
6. BRODIE MJ, DUNCAN R, VESPIGNANI H, SOLYOM A, BITENSKYY V, LUCAS C. Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures. Epilepsia 2005;46:31-41.
7. ALAPATI A, HALL-BELL C, FAUGHT E. Safety and efficacy of zonisamide as adjunctive therapy for refractory complex partial seizures: an open-label study. Epilepsia 2000;41:225 (Abstract 3.201).
8. FRENCH JA, RUELLE AD. Zonisamide reduces seizure frequency over time in long-term continuation studies. Epilepsia 2002;43:241 (Abstract F.06).
9. BRODIE MJ. Zonisamide clinical trials: European experience. Seizure 2004;13(Suppl. 1):S66-70. discussion S71-2.
10. FAUGHT E. Review of United States and European clinical trials of zonisamide in the treatment of refractory partial-onset seizures. Seizure 2004;13(Suppl. 1):S59-65. discussion S71-2.
11. WROE S. Zonisamide and renal calculi in patients with epilepsy: how big an issue? Curr Med Res Opin 2007; 23:1765-73.
12. ZACCARA G, MESSORI A, CINCOTTA M, BURCHINI G. Comparison of the efficacy and tolerability of new antiepileptic drugs: what can we learn from long-term studies? Acta Neurol Scand 2006;114:157-68.
13. GUBERMAN A, BRUNI J. Long-term open multicentre, add-on trial of vigabatrin in adult resistant partial epilepsy. The Canadian Vigabatrin Study Group. Seizure 2000;9:112-8.
14. REMY C, BEAUMONT D. Efficacy and safety of vigabatrin in the long-term treatment of refractory epilepsy. Br J Clin Pharmacol 1989;27(Suppl. 1):125S-9S.
15. LHATOO SD, WONG IC, POLIZZI G, SANDER JW. Long-term retention rates of lamotrigine, gabapentin, and topiramate in chronic epilepsy. Epilepsia 2000;41:1592-6.
16. CHUNG S, WANG N, HANK N. Comparative retention rates and long-term tolerability of new antiepileptic drugs. Seizure 2007; 16:296-304. 94-98