The specificity and polymorphism of the MHC class I prevents the global adaptation of HIV-1 to the monomorphic proteasome and TAP

PLoS ONE

Volumn 3, Issue 10, 2008, Pages

  Schmid, Boris V ^a   Keşmir, Can ^a,b   de Boer, Rob J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; ABC TRANSPORTER; T LYMPHOCYTE RECEPTOR; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING (TAP); UNCLASSIFIED DRUG;

ALGORITHM; AMINO ACID SEQUENCE; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; EPITOPE MAPPING; EVOLUTIONARY ADAPTATION; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; MUTATIONAL ANALYSIS; PREDICTION; PROTEIN TRANSPORT; VIRUS TRANSMISSION; ADAPTATION; BIOLOGICAL MODEL; BIOLOGY; CYTOTOXIC T LYMPHOCYTE; GENE; GENETIC POLYMORPHISM; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; POPULATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADAPTATION, BIOLOGICAL; AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ATP-BINDING CASSETTE TRANSPORTERS; COMPUTATIONAL BIOLOGY; GENES, MHC CLASS I; HIV-1; HUMANS; IMMUNE TOLERANCE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; POPULATION; PROTEASOME ENDOPEPTIDASE COMPLEX; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTES, CYTOTOXIC;

EID: 55849136510     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003525     Document Type: Article

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