Potential of microemulsions in drug delivery and therapeutics: A patent review

Recent Patents on Drug Delivery and Formulation

Volumn 2, Issue 2, 2008, Pages 136-144

  Bali, Vikas ^a   Bhavna, ^a   Ali, Mushir ^a   Baboota, Sanjula ^a   Ali, Javed ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Cosurfactant; Drug delivery; Microemulsion; Oil; Patent; Solubility; Surfactant

Indexed keywords

ACRYLIC ACID; ALPHA TOCOPHEROL; ANTIINFECTIVE AGENT; BIOPOLYMER; CALCITONIN; COPOLYMER; COSURFACTANT; CYCLOSPORIN A; DIAZEPAM; DRUG CARRIER; EMOLLIENT AGENT; ETHYLENE OXIDE; GONADORELIN DERIVATIVE; HYDROXYPROPYLCELLULOSE; MACROGOL; MONOMER; NANOPARTICLE; NEEM OIL; NONIONIC SURFACTANT; NUTRACEUTICAL; PACLITAXEL; PEPTIDE DERIVATIVE; POLOXAMER; POLYETHYLENE; POLYMER; PROPYLENE GLYCOL; RIBOFLAVIN DERIVATIVE; SORBITAN PALMITATE; SURFACTANT; UNINDEXED DRUG;

AQUEOUS SOLUTION; BIOCOMPATIBILITY; BIODEGRADABILITY; CHEMICAL STRUCTURE; CONTROLLED DRUG RELEASE; CROSS LINKING; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; DRUG TOLERABILITY; ENTROPY; EPILEPTIC STATE; HUMAN; HYDROPHOBICITY; INTRANASAL DRUG ADMINISTRATION; LIPOPHILICITY; MICELLE; MICROEMULSION; ORAL DRUG ADMINISTRATION; PARENTERAL DRUG ADMINISTRATION; PARTICLE SIZE; PATENT; PHYSICAL CHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; REVIEW; SEIZURE; STRUCTURE ANALYSIS; THERMODYNAMICS; TOPICAL DRUG ADMINISTRATION;

BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; HUMANS; OILS; PATENTS AS TOPIC; SOLUBILITY; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 55849091046     PISSN: 18722113     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221108784534072     Document Type: Review

References (77)

1. Hoar TP, Schulman JH. Transparent water-in-oil dispersions: the oleopathic hydro-micelle. Nature1943; 152: 102-103.
2. Schulman JH, Stoeckenius W, Prince LM. Mechanism of formation and structure of micro emulsions by electron microscopy. J Phys Chem 1959; 63: 1677-680.
3. Swarbrick J, Boylan JC. Microemulsions; In: Encyclopedia of Pharmaceutical Technology. New York, Marcel Dekker 1994; 375-421.
4. Danielsson I, Lindman B. The definition of a microemulsion. Coll Surf 1981; 3: 391-392.
5. Kreuter J. Microemulsions; In: colloidal drug delivery systems. New York, Marcel Dekker1994; 31-71.
6. De Gennes PG, Taupin C. Microemulsioins and the flexibility of oil/water interfaces. J Phys Chem1982; 86: 2294.
7. Cook, E.J., Lagace, A.P.: US4908154 (1987).
8. Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev 2000; 45: 89-121.
9. Spernath A, Aserin A. Microemulsions as carriers for drugs and nutraceuticals. Adv Colloid Interface Sci 2006; 128-130: 47-64.
10. Ghosh PK, Murthy RSR. Microemulsions: a potential drug delivery system. Curr Drug Del 2006; 3: 167-180.
11. Ritschel WA. Microemulsions for improved peptide absorption from the gastrointestinal tract. Meth Find Exp Clin Pharmacol 1993; 13: 205-220.
12. Constantinides PP, Scalart JP, Lancaster C, et al. Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides. Pharm Res 1994; 11: 1385-1390.
13. Constantinides PP, Lancaster CM, Marcello J, et al. Enhanced intestinal absorption of an RGD peptide from water-in-oil microemulsions of different composition and particle size. J Control Rel 1995; 34: 109-116.
14. Gao ZG, Choi HG, Shin HJ, et al. Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A. Int J Pharm 1998; 161: 75-86.
15. Vyas SP, Khar RK. Submicron Emulsions; In: Targeted and Controlled Drug Delivery Novel Carrier Systems. New Delhi, CBS Publishers 2002; 280-302.
16. Kim CK, Ryuu SA, Park KM, Lim SJ, Hwang SJ. Preparation and physicochemical characterization of phase inverted water/oil microemulsion containing cyclosporin A. Int J Pharm 1997; 147: 131-134.
17. Naicker, S.A., Yatscoff, R.W.: US20067060672 (2006).
18. Patel, S.P.: US20067153834 (2006).
19. Gao, P., Morozowich, W.: US20067115565 (2006).
20. Barthelemy, P., Benameur, H.: US20016309665 (2001).
21. Appelqvist, I.A.M., Malone, M.E., Nandi, A.: US20077192572 (2007).
22. Tabibi, E., Siciliano, A.A.: US5130122 (1992).
23. Tabibi, E., Siciliano, A.A.: US5130122 (1990).
24. Jadhav KR, Shaikh IM, Ambade KW, Kadam VJ. Applications of microemulsion based drug delivery system. Curr Drug Del 2006; 3: 267-273.
25. Park KM, Kim CK. Preparation and evaluation of flurbiprofenloaded microemulsion for Parenteral delivery. Int J Pharm 1999; 181: 173-179.
26. Autuori, F., Bianchini, C., Bottoni, G., Leoni, F., Mascagni, P., Monzani, V., Piccolo, O.: US20077157099 (2007).
27. Dennis, D.M., Gravenstein, N., Modell, J.H., Morey, T.E., Shah, D.: US20036623765 (2003).
28. Dennis, D.M., Gravenstein, N., Modell, J.H., Morey, T.E., Shah, D.: US20036638537 (2003).
29. Ljusberg-Wahren, H., Lundberg, D., Holmberg, K.: US20070031485 (2007).
30. Poli, S., Mailland, F., Moro, L.: US5759566 (1998).
31. Discher, D.E., Discher, B.M., Won, Y.-Y., Lee, J.C.-M., Hammer, D.A., Bates, F.: US20077217427 (2007).
32. Hong, C.I., Kim, J.W., Choi, N.H., Shin, H.J., Yang, S.G., Kim, J.H., Lim, J.L., Kim, C.K.: US20016306434 (2001).
33. Peltola S, Saarinen-Savolainen P, Kiesvaara J, Suhonen TM, Urtti A. Microemulsions for topical delivery of estradiol. Int J Pharm 2003; 254: 99-107.
34. Parmar, B.S., Varshney, M., Shah, D.O.: US20046703034 (2004).
35. Choi, Y.M., Kim, K.H.: WO04110403 (2004).
36. Sonneville-Aubrun O, Simonnet J-T, L'Alloret F. Nanoemulsioins: a new vehicle for skincare products. Adv Colloid Interface Sci 2004; 108-109: 145-149.
37. Bowen-Leaver, H.A., Tadlock, C.C., George, L.: US20067153516 (2006).
38. Narasimhan, S., Chan, A.C., Duffer, D.I., Hawkins, G.R.: US20016315989 (2001).
39. Petchul, J., Gaudreault, R.: US5336432 (1994).
40. Petchul, J., Gaudreault, R.: US5575948 (1996).
41. Schroder, F., Lang, G.: US5298240 (1994).
42. Bergmann, W., Bees, J.: US5077040 (1991).
43. Diec, K.H., Meier, W., Schreiber, J.: US20026468551 (2002).
44. Riccio, D.A., Merrifield, J.H.: US5759530 (1998).
45. Kim CK, Cho YJ, Gao ZG. Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery. J Control Release 2001; 70: 149-155.
46. Mulye, N.: US20036638522 (2003).
47. Cottens, S., Haeberlin, B., Sedrani, R., Vonderscher, J.: US20077205279 (2007).
48. Nagahama, T., Hasegawa, K.: US20016303662 (2001).
49. Ekwuribe, N.N., Ramaswamy, M., Radhakrishnan, B., Allaudeen, H.S.: US20016191105 (2001).
50. Takahashi, M., Matsushita, H.: US5948825 (1999).
51. Owen, A.J., Yiv, S.H., Sarkahian, A.B.: US5688761 (1997).
52. Menon, V.P., Kumar, K., Nelson, C.T., Rizzardi, D.A.: US20070032719 (2007).
53. Dietz, T.M., Lu, Y.Y., Uy, R., Young, C.I.: US5952398 (1999).
54. Dietz, T.M., Lu, Y.Y., Uy, R., Young, C.I.: US5779632 (1998).
55. Uy, R., Young, C.I.: US20046709716 (2004).
56. McKee, G.E., Renz, G., Jahns, E., Kastenhuber, W.: US20016177525 (2001).
57. Wu, H.S.: US5523346 (1996).
58. Wu, H.S.: US5385694 (1995).
59. Outubuddin, S.: US5238992 (1993).
60. Turner, S.R., Siano, D.B., Bock, J.: US4521580 (1985).
61. Eagland, D., Crowther, N.J.: US20077202300 (2007).
62. Razdan R, Devarajan PV. Microemulsion - A review. Indian Drugs 2003; 40: 139-146.
63. Feil, M.C.: US4722904 (1988).
64. Yiv, S.H.: US4975468 (1990).
65. Yiv, S., Li, M., D'Cruz, O., Uckun, F.M.: US20067064114 (2006)
66. Mattox, J.R.: US4954338 (1990).
67. 10. Int J Pharm 2001; 212: 233-246.
68. Spernath A, Yaghmur A, Aserin A, Hoffman RE, Garti N. Food-grade microemulsions based on non-ionic emulsifiers: media to enhance lycopene solubilisation. J Agric Food Chem 2002; 50: 6917-922.
69. Amar I, Aserin A, Garti N. Solubilization patterns of lutein and lutein esters in food grade non ionic microemulsions. J Agric Food Chem 2003; 51: 4775-781.
70. Spernath A, Yaghmur A, Aserin A, Hoffman RE, Garti N. Self-diffusion nuclear magnetic resonance, microstructure transitions, and solubilization capacity of phytosterols and cholesterol in Winsor IV food-grade microemulsions. J Agric Food Chem 2003; 51: 2359-364.
71. Garti, N., Aserin, A., Spernath, A., Amar, I.: US20077182950 (2007).
72. Bauer, K., Neuber, C., Schmid, A., Volker, K.M.: US20026426078 (2002).
73. Chmiel, O., Traitler, H., Voepel, K.: US5674549 (1997).
74. El-Nokaly, M., Hiler, G.D., McGrady, J.: US5045337 (1991).
75. Mumper, R.J., Jay, M.: US20067153525 (2006).
76. Maria, G.M.: WO06128888 (2006).
77. Chhabra, V., Kulkarni, B.S., Bhargava, R.N.: US20006036886 (2000).