Association of Mycoplasma arthritidis mitogen with lethal toxicity but not with arthritis in mice

Infection and Immunity

Volumn 76, Issue 11, 2008, Pages 4989-4998

  Luo, Wenyi ^a   Yu, Huilan ^a   Cao, Zuhua ^a   Schoeb, Trenton R ^a   Marron, Michele ^b   Dybvig, Kevin ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; MITOGENIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTHRITIS; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; MITOGENESIS; MORTALITY; MOUSE; MYCOPLASMA ARTHRITIDIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, BACTERIAL; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, INFECTIOUS; FEMALE; MICE; MYCOPLASMA ARTHRITIDIS; MYCOPLASMA INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUPERANTIGENS;

EID: 55849087576     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00667-08     Document Type: Article

References (53)

1. Baccala, R., L. R. Smith, M. Vestberg, P. A. Peterson, B. C. Cole, and A. N. Theofilopoulos. 1992. Mycoplasma arthritidis mitogen. V beta engaged in mice, rats, and humans, and requirement of HLA-DR alpha for presentation. Arthritis Rheum. 35:434-442.
2. Bhardwaj, N., A. S. Hodtsev, A. Nisanian, S. Kabak, S. M. Friedman, B. C. Cole, and D. N. Posnett. 1994. Human T-cell responses to Mycoplasma arthritidis-derived superantigen. Infect. Immun. 62:135-144.
3. Binder, A., H. J. Hedrich, K. Wonigeit, and H. Kirchhoff. 1993. The Mycoplasma arthritidis infection in congenitally athymic nude rats. J. Exp. Anim. Sci. 35:177-185.
4. Cahill, J. F., B. C. Cole, B. B. Wiley, and J. R. Ward. 1971. Role of biological mimicry in the pathogenesis of rat arthritis induced by Mycoplasma arthritidis. Infect. Immun. 3:24-35.
5. Cannon, G. W., B. C. Cole, J. R. Ward, J. L. Smith, and E. J. Eichwald. 1988. Arthritogenic effects of Mycoplasma arthritidis T cell mitogen in rats. J. Rheumatol. 15:735-741.
6. Carsetti, R. 2004. Characterization of B-cell maturation in the peripheral immune system. Methods Mol. Biol. 271:25-35.
7. Clapper, B., A.-H. T. Tu, A. Elgavish, and K. Dybvig. 2004. The vir gene of bacteriophage MAV1 confers resistance to phage infection on Mycoplasma arthritidis. J. Bacteriol. 186:5715-5720.
8. Clapper, B., A.-H. T. Tu, W. L. Simmons, and K. Dybvig. 2004. Bacteriophage MAV1 is not associated with virulence of Mycoplasma arthritidis. Infect. Immun. 72:7322-7325.
9. Clark, H. W., M. R. Coker-Vann, J. S. Bailey, and T. M. Brown. 1988. Detection of mycoplasmal antigens in immune complexes from rheumatoid arthritis synovial fluids. Ann. Allergy 60:394-398.
10. Cole, B. C. 1991. The immunobiology of Mycoplasma arthritidis and its superantigen MAM. Curr. Top. Microbiol. Immunol. 174:107-119.
11. Cole, B. C., and C. L. Atkin. 1991. The Mycoplasma arthritidis T-cell mitogen, MAM: a model superantigen. Immunol. Today 12:271-276.
12. Cole, B. C., and G. H. Cassell. 1979. Mycoplasma infections as models of chronic joint inflammation. Arthritis Rheum. 22:1375-1381.
13. Cole, B. C., C. S. David, D. H. Lynch, and D. R. Kartchner. 1990. The use of transfected fibroblasts and transgenic mice establishes that stimulation of T cells by the Mycoplasma arthritidis mitogen is mediated by E alpha. J. Immunol. 144:420-424.
14. Cole, B. C., R. A. Daynes, and J. R. Ward. 1981. Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. I. Transformation is associated with an H-2-linked gene that maps to the I-E/I-C subregion. J. Immunol. 127:1931-1936.
15. Cole, B. C., and M. M. Griffiths. 1993. Triggering and exacerbation of autoimmune arthritis by the Mycoplasma arthritidis superantigen MAM. Arthritis Rheum. 36:994-1002.
16. Cole, B. C., D. R. Kartchner, and D. J. Wells. 1989. Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. VII. Responsiveness is associated with expression of a product(s) of the V beta 8 gene family present on the T cell receptor alpha/beta for antigen. J. Immunol. 142:4131-4137.
17. Cole, B. C., K. L. Knudston, A. Oliphant, A. D. Sawitzke, A. Pole, M. Manohar, L. S. Benson, E. Ahmed, and C. L. Atkin. 1996. The sequence of the Mycoplasma arthritidis superantigen, MAM: identification of functional domains and comparison with microbial superantigens and plant lectin mitogens. J. Exp. Med. 183:1105-1110.
18. Cole, B. C., M. W. Piepkorn, and E. C. Wright. 1985. Influence of genes of the major histocompatibility complex on ulcerative dermal necrosis induced in mice by Mycoplasma arthritidis. J. Investig. Dermatol. 85:357-361.
19. Cole, B. C., A. D. Sawitzke, E. A. Ahmed, C. L. Atkins, and C. S. David. 1997. Allelic polymorphisms at the H-2A and HLA-DQ loci influence the response of murine lymphocytes to the Mycoplasma superantigen MAM. Infect. Immun. 65:4190-4198.
20. Cole, B. C., R. N. Thorpe, L. A. Hassell, L. R. Washburn, and J. R. Ward. 1983. Toxicity but not arthritogenicity of Mycoplasma arthritidis for mice associates with the haplotype expressed at the major histocompatibility complex. Infect. Immun. 41:1010-1015.
21. Cole, B. C., J. R. Ward, and L. Golightly-Rowland. 1973. Factors influencing the susceptibility of mice to Mycoplasma arthritidis. Infect. Immun. 7:218-225.
22. Cole, B. C., J. R. Ward, K. S. Jones, and J. F. Cahill. 1971. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis. I. Induction of disease and histopathological characteristics. Infect. Immun. 4:344-355.
23. Cole, B. C., L. R. Washburn, G. J. Sullivan, and J. R. Ward. 1982. Specificity of a mycoplasma mitogen for lymphocytes from human and various animal hosts. Infect. Immun. 36:662-666.
24. Crow, M. K., G. Zagon, Z. Chu, B. Ravina, J. R. Tumang, B. C. Cole, and S. M. Friedman. 1992. Human B cell differentiation induced by microbial superantigens: unselected peripheral blood lymphocytes secrete polyclonal immunoglobulin in response to Mycoplasma arthritidis mitogen. Autoimmunity 14:23-32.
25. Diedershagen, M., S. Overbeck, S. Arlt, B. Plumakers, M. Lintges, and L. Rink. 2007. Mycoplasma arthritidis-derived superantigen (MAM) displays DNase activity. FEMS Immunol. Med. Microbiol. 49:266-271.
26. D'Orazio, J. A., B. C. Cole, and J. Stein-Streilein. 1996. Mycoplasma arthritidis mitogen up-regulates human NK cell activity. Infect. Immun. 64:441-447.
27. Dybvig, K., J. W. Simecka, H. L. Watson, and G. H. Cassell. 1989. High-frequency variation in Mycoplasma pulmonis colony size. J. Bacteriol. 171:5165-5168.
28. Dybvig, K., C. Zuhua, P. Lao, D. S. Jordan, C. T. French, A.-H. T. Tu, and A. E. Loraine. 2008. Genome of Mycoplasma arthritidis. Infect. Immun. 76:4000-4008.
29. Emery, P., G. S. Panayi, K. I. Welsh, and B. C. Cole. 1985. Rheumatoid factors and HLA-DR4 in RA. J. Rheumatol. 12:217-222.
30. French, C. T., P. Lao, A. E. Loraine, B. T. Matthews, H. Yu, and K. Dybvig. 2008. Large-scale transposon mutagenesis of Mycoplasma pulmonis. Mol. Microbiol. 69:67-76.
31. Hodtsev, A. S., Y. Choi, E. Spanopoulou, and D. N. Posnett. 1998. Mycoplasma superantigen is a CDR3-dependent ligand for the T cell antigen receptor. J. Exp. Med. 187:319-327.
32. Howell, M. D., J. P. Diveley, K. A. Lundeen, A. Esty, S. T. Winters, D. J. Carlo, and S. W. Brostoff. 1991. Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 88:10921-10925.
33. Li, H., Y. Zhao, Y. Guo, S. J. Vanvranken, Z. Li, L. Eisele, and W. Mourad. 2007. Mutagenesis, biochemical, and biophysical characterization of Mycoplasma arthritidis-derived mitogen. Mol. Immunol. 44:763-773.
34. Mu, H. H., N. D. Pennock, J. Humphreys, C. J. Kirschning, and B. C. Cole. 2005. Engagement of Toll-like receptors by mycoplasmal superantigen: downregulation of TLR2 by MAM/TLR4 interaction. Cell. Microbiol. 7:789-797.
35. Mu, H. H., A. D. Sawitzke, and B. C. Cole. 2000. Modulation of cytokine profiles by the mycoplasma superantigen Mycoplasma arthritidis mitogen parallels susceptibility to arthritis induced by M. arthritidis. Infect. Immun. 68:1142-1149.
36. d mutation influences cytokine regulation in vivo by the Mycoplasma arthritidis mitogen superantigen and lethal toxicity in mice infected with M. arthritidis. Infect. Immun. 69:3837-3844.
37. Pour-El, I., C. Adams, and F. C. Minion. 2002. Construction of mini-Tn4001tet and its use in Mycoplasma gallisepticum. Plasmid 47:129-137.
38. Proft, T., and J. D. Fraser. 2003. Bacterial superantigens. Clin. Exp. Immunol. 133:299-306.
39. Sawitzke, A., D. Joyner, K. Knudtson, H. H. Mu, and B. Cole. 2000. Anti-MAM antibodies in rheumatic disease: evidence for a MAM-like superantigen in rheumatoid arthritis? J. Rheumatol. 27:358-364.
40. Simmons, W. L., and K. Dybvig. 2003. The Vsa proteins modulate susceptibility of Mycoplasma pulmonis to complement killing, hemadsorption, and adherence to polystyrene. Infect. Immun. 71:5733-5738.
41. Teachman, A. M., C. T. French, H. Yu, W. L. Simmons, and K. Dybvig. 2002. Gene transfer in Mycoplasma pulmonis. J. Bacteriol. 184:947-951.
42. Tu, A.-H., J. R. Lindsey, T. R. Schoeb, A. Elgavish, H. Yu, and K. Dybvig. 2002. Role of bacteriophage MAV1 as a mycoplasmal virulence factor for the development of arthritis in mice and rats. J. Infect. Dis. 186:432-435.
43. Tu, A.-H. T., B. Clapper, T. R. Schoeb, A. Elgavish, J. Zhang, L. Liu, H. Yu, and K. Dybvig. 2005. Association of a major protein antigen of Mycoplasma arthritidis with virulence. Infect. Immun. 73:245-249.
44. Voelker, L. L., and K. Dybvig. 1998. Characterization of the lysogenic bacteriophage MAV1 from Mycoplasma arthritidis. J. Bacteriol. 180:5928-5931.
45. Voelker, L. L., and K. Dybvig. 1996. Gene transfer in Mycoplasma arthritidis: transformation, conjugal transfer of Tn916, and evidence for a restriction system recognizing AGCT. J. Bacteriol. 178:6078-6081.
46. Voelker, L. L., K. E. Weaver, L. J. Ehle, and L. R. Washburn. 1995. Association of lysogenic bacteriophage MAV1 with virulence of Mycoplasma arthritidis. Infect. Immun. 63:4016-4023.
47. Washburn, L. R., D. W. Bird, and K. Dybvig. 2003. Restoration of cytoadherence to an adherence-deficient mutant of Mycoplasma arthritidis by genetic complementation. Infect. Immun. 71:671-675.
48. Washburn, L. R., B. C. Cole, M. I. Gelman, and J. R. Ward. 1980. Chronic arthritis of rabbits induced by mycoplasmas. I. Clinical, microbiologic, and histologic features. Arthritis Rheum. 23:825-836.
49. Washburn, L. R., S. Hirsch, and L. L. Voelker. 1993. Mechanisms of attachment of Mycoplasma arthritidis to host cells in vitro. Infect. Immun. 61:2670-2680.
50. Washburn, L. R., E. J. Miller, and K. E. Weaver. 2000. Molecular characterization of Mycoplasma arthritidis membrane lipoprotein MAA1. Infect. Immun. 68:437-442.
51. Washburn, L. R., and E. J. Weaver. 1997. Protection of rats against Mycoplasma arthritidis-induced arthritis by active and passive immunizations with two surface proteins. Clin. Diagn. Lab. Immunol. 4:321-327.
52. Xu, J., Z. Liu, T. L. Clemens, and J. L. Messina. 2006. Insulin reverses growth hormone-induced homologous desensitization. J. Biol. Chem. 281:21594-21606.
53. Zimmerman, C.-U., and R. Herrmann. 2005. Synthesis of a small, cysteine-rich, 29 amino acids long peptide in Mycoplasma pneumoniae. FEMS Microbiol. Lett. 253:315-321.