Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells

Journal of Periodontology

Volumn 79, Issue 11, 2008, Pages 2182-2189

  Mizuno, Noriyoshi ^a   Shiba, Hideki ^a   Inui, Takafumi ^a   Takeda, Katsuhiro ^a   Kajiya, Mikihito ^a   Hasegawa, Naohiko ^a   Kawaguchi, Hiroyuki ^a   Kurihara, Hidemi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Cells; Neurotrophin 4; Neurotrophin 5; Periodontal ligament; Regeneration

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; DNA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; NEUROTROPHIN 4; OSTEOPONTIN;

ADOLESCENT; ADULT; ARTICLE; BIOSYNTHESIS; BONE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CEMENTUM; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; PERIODONTAL LIGAMENT; PHYSIOLOGY;

ADOLESCENT; ADULT; ALKALINE PHOSPHATASE; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DENTAL CEMENTUM; DNA; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; NERVE GROWTH FACTORS; OSTEOPONTIN; PERIODONTAL LIGAMENT; RECEPTOR, TRKB; RNA, MESSENGER; YOUNG ADULT;

EID: 55749095041     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2008.070402     Document Type: Article

References (25)

1. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. The trk proto-oncogene product: A signal transducing receptor for nerve growth factor. Science 1991;252:554-558.
2. Klein R, Nanduri V, Jing SA, et al. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 1991;66:395-403.
3. Lamballe F, Klein R, Barbacid M. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 1991;66:967-979.
4. Barrett GL. The p75 neurotrophin receptor and neuronal apoptosis. Prog Neurobiol 2000;61:205-229.
5. Johnson D, Lanahan A, Buck CR, et al. Expression and structure of the human NGF receptor. Cell 1986;47:545-554.
6. Otten U, Ehrhard P, Peck R. Nerve growth factor induces growth and differentiation of human B lymphocytes. Proc Natl Acad Sci USA 1989;86:10059-10063.
7. Boyle MD, Lawman MJ, Gee AP, Young M. Nerve growth factor: A chemotactic factor for polymorphonuclear leukocytes in vivo. J Immunol 1985;134:564-568.
8. Donovan MJ, Lin MI, Wiegn P, et al. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development 2000;127:4531-4540.
9. Liu ZZ, Zhu LQ, Eide FF. Critical role of TrkB and brain-derived neurotrophic factor in the differentiation and survival of retinal pigment epithelium. J Neurosci 1997;17:8749-8755.
10. Glass DJ, Nye SH, Hantzopoulos P, et al. TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor. Cell 1991;66:405-413.
11. Steinle JJ, Granger HJ. Nerve growth factor regulates human choroidal, but not retinal, endothelial cell migration and proliferation. Auton Neurosci 2003;108:57-62.
12. Fan CG, Zhang QJ, Tang FW, Han ZB, Wang GS, Han ZC. Human umbilical cord blood cells express neurotrophic factors. Neurosci Lett 2005;380:322-325.
13. Hikawa S, Kobayashi H, Hikawa N, et al. Expression of neurotrophins and their receptors in peripheral lung cells of mice. Histochem Cell Biol 2002;118:51-58.
14. Grills BL, Schuijers JA. Immunohistochemical localization of nerve growth factor in fractured and unfractured rat bone. Acta Orthop Scand 1998;69:415-419.
15. Nosrat CA, Fried K, Lindskog S, Olson L. Cellular expression of neurotrophin mRNAs during tooth development. Cell Tissue Res 1997;290:569-580.
16. Marconi A, Terracina M, Fila C, et al. Expression and function of neurotrophins and their receptors in cultured human keratinocytes. J Invest Dermatol 2003;121:1515-1521.
17. Kurihara H, Shinohara H, Yoshino H, Takeda K, Shiba H. Neurotrophins in cultured cells from periodontal tissues. J Periodontol 2003;74:76-84.
18. Xu WP, Mizuno N, Shiba H, et al. Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor. J Periodontol 2006;77:800-807.
19. Takeda K, Shiba H, Mizuno N, et al. Brain-derived neurotrophic factor enhances periodontal tissue regeneration. Tissue Eng 2005;11:1618-1629.
20. Xiao G, Gopalakrishnan R, Jiang D, et al. Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res 2002;17:101-110.
21. Yuspa SH, Harris CC. Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro. Exp Cell Res 1974;86:95-105.
22. Kanno T, Takahashi T, Tsujisawa T, Ariyoshi W, Nishihara T. Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J Cell Biochem 2007;101:1266-1277.
23. Spector JA, Mathy JA, Warren SM, et al. FGF-2 acts through an ERK1/2 intracellular pathway to affect osteoblast differentiation. Plast Reconstr Surg 2005;115:838-852.
24. Mimori K, Komaki M, Iwasaki K, Ishikawa I. Extracellular signal-regulated kinase 1/2 is involved in ascorbic acid-induced osteoblastic differentiation in periodontal ligament cells. J Periodontol 2007;78:328-334.
25. Pincelli C, Sevignani C, Manfredini R, et al. Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes. J Invest Dermatol 1994;103:13-18.