메뉴 건너뛰기




Volumn 20, Issue 6, 2008, Pages 685-689

Erythropoietin in cancer-related anemia

Author keywords

Anemia; Cancer; Erythropoietin; Survival; Venous thromboembolism

Indexed keywords

DEXTRAN; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; FERRIC GLUCONATE; IRON; IRON SACCHARATE; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; PLACEBO;

EID: 55749090066     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e3283136971     Document Type: Review
Times cited : (9)

References (33)
  • 1
    • 34250349152 scopus 로고    scopus 로고
    • Weighing the hazards of erythropoiesis stimulation in patients with cancer
    • Khuri FR. Weighing the hazards of erythropoiesis stimulation in patients with cancer. N Engl J Med 2007; 356:2445-2448.
    • (2007) N Engl J Med , vol.356 , pp. 2445-2448
    • Khuri, F.R.1
  • 2
    • 38549178915 scopus 로고    scopus 로고
    • Erythropoietin analogues: An unnecessary class of drugs
    • Erythropoietin analogues: an unnecessary class of drugs. Lancet Oncol 2008; 9:81.
    • (2008) Lancet Oncol , vol.9 , pp. 81
  • 3
    • 70349609397 scopus 로고    scopus 로고
    • Sacrificing the cash cow. Nat Biotechnol 2007; 25:363.
    • Sacrificing the cash cow. Nat Biotechnol 2007; 25:363.
  • 4
    • 55749092185 scopus 로고    scopus 로고
    • Melosky BL Erythropoiesis-stimulating agents: benefits and risks in supportive care of cancer. Curr Oncol 2008; 15:S10-S15.
    • Melosky BL Erythropoiesis-stimulating agents: benefits and risks in supportive care of cancer. Curr Oncol 2008; 15:S10-S15.
  • 5
    • 37849003198 scopus 로고    scopus 로고
    • Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update
    • The current standard clinical practice guidelines on the use of ESAs in cancer patients
    • Rizzo JD, Someffield MR Hagerty KL, et al. Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update. J Clin Oncol 2008; 26:132-149. The current standard clinical practice guidelines on the use of ESAs in cancer patients.
    • (2008) J Clin Oncol , vol.26 , pp. 132-149
    • Rizzo, J.D.1    Someffield, M.R.2    Hagerty, K.L.3
  • 6
    • 34447095903 scopus 로고    scopus 로고
    • Risks and benefits of erythropoiesie-stimulating agents in cancer management
    • Beutel G, Ganser A. Risks and benefits of erythropoiesie-stimulating agents in cancer management Semin Hematol 2007; 44:157-165.
    • (2007) Semin Hematol , vol.44 , pp. 157-165
    • Beutel, G.1    Ganser, A.2
  • 7
    • 41949140285 scopus 로고    scopus 로고
    • Darbepoetin alpha for the treatment of anemia in patients with active cancer not receiving chemotherapy or radiotherapy: Results of a phase III, multicenter, randomized, double-blind, placebo controlled study
    • This randomized trial demonstrated an increased risk of thromboembolism and shorter survival in anemic cancer patients receiving ESA treatment
    • Smith RE, Aapro MS, Ludwig H, et al. Darbepoetin alpha for the treatment of anemia in patients with active cancer not receiving chemotherapy or radiotherapy: results of a phase III, multicenter, randomized, double-blind, placebo controlled study. J Clin Oncol 2008; 26:1040-1050. This randomized trial demonstrated an increased risk of thromboembolism and shorter survival in anemic cancer patients receiving ESA treatment.
    • (2008) J Clin Oncol , vol.26 , pp. 1040-1050
    • Smith, R.E.1    Aapro, M.S.2    Ludwig, H.3
  • 8
    • 34648833614 scopus 로고    scopus 로고
    • Gabrilove JL, Ferez EA, Tomita DK, et al. Assessing symptom burden using the M. D. Anderson symptom inventory in patients with chemotherapy-induced anemia: results of a multicenter, open-label study (SURPASS) of patients treated with darbepoetin-alpha at a dose of 200 microg every 2 weeks. Cancer 2007; 110:1629-1640.
    • Gabrilove JL, Ferez EA, Tomita DK, et al. Assessing symptom burden using the M. D. Anderson symptom inventory in patients with chemotherapy-induced anemia: results of a multicenter, open-label study (SURPASS) of patients treated with darbepoetin-alpha at a dose of 200 microg every 2 weeks. Cancer 2007; 110:1629-1640.
  • 9
    • 33847046008 scopus 로고    scopus 로고
    • Intravenous ferric gluconate significantly improves response to epoetin alfa versus oral iron or no iron in anemic patients with cancer receiving chemotherapy
    • Henry DH, Dahl NV, Auerbach M, et al. Intravenous ferric gluconate significantly improves response to epoetin alfa versus oral iron or no iron in anemic patients with cancer receiving chemotherapy. Oncologist 2007; 12:231-242.
    • (2007) Oncologist , vol.12 , pp. 231-242
    • Henry, D.H.1    Dahl, N.V.2    Auerbach, M.3
  • 10
    • 33947405774 scopus 로고    scopus 로고
    • Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: A randomized multicenter study
    • Hedenus M, Birgegȧrd G, Näsman P, et al. Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study. Leukemia 2007; 21:627-632.
    • (2007) Leukemia , vol.21 , pp. 627-632
    • Hedenus, M.1    Birgegȧrd, G.2    Näsman, P.3
  • 11
    • 43249121140 scopus 로고    scopus 로고
    • Randomized trial of intravenous iron supplementation in patients with chemotherapy-related anemia without iron deficiency treated with darbepoetin alpha
    • Pedrazzoli P, Farris A, Del Prete S, et al. Randomized trial of intravenous iron supplementation in patients with chemotherapy-related anemia without iron deficiency treated with darbepoetin alpha. J Clin Oncol 2008; 26:1619-1625.
    • (2008) J Clin Oncol , vol.26 , pp. 1619-1625
    • Pedrazzoli, P.1    Farris, A.2    Del Prete, S.3
  • 12
    • 43249129663 scopus 로고    scopus 로고
    • Randomized, multicenter, controlled trial comparing the efficacy and safety of darbepoetin alpha administered every 3 weeks with or without intravenous iron in patients with chemotherapy-induced anemia
    • The largest trial comparing intravenous iron to placebo in cancer patients receiving ESAs. Intravenous iron improved the hematologic response rate and reduced the incidence of transfusions
    • Bastit L, Vandebroek A, Altintas S, et al. Randomized, multicenter, controlled trial comparing the efficacy and safety of darbepoetin alpha administered every 3 weeks with or without intravenous iron in patients with chemotherapy-induced anemia. J Clin Oncol 2008; 26:1611-1618. The largest trial comparing intravenous iron to placebo in cancer patients receiving ESAs. Intravenous iron improved the hematologic response rate and reduced the incidence of transfusions.
    • (2008) J Clin Oncol , vol.26 , pp. 1611-1618
    • Bastit, L.1    Vandebroek, A.2    Altintas, S.3
  • 13
    • 43249124234 scopus 로고    scopus 로고
    • Should intravenous iron be the standard of care in oncology?
    • Auerbach M. Should intravenous iron be the standard of care in oncology? J Clin Oncol 2008; 26:1579-1581.
    • (2008) J Clin Oncol , vol.26 , pp. 1579-1581
    • Auerbach, M.1
  • 14
    • 34247615981 scopus 로고    scopus 로고
    • Clinical update: Intravenous iron for anaemia
    • Auerbach M, Ballard H, Glaspy J. Clinical update: intravenous iron for anaemia. Lancet 2007; 369:1502-1504.
    • (2007) Lancet , vol.369 , pp. 1502-1504
    • Auerbach, M.1    Ballard, H.2    Glaspy, J.3
  • 15
    • 33846339172 scopus 로고    scopus 로고
    • EORTC guidelines for the use of erythropoietic proteins in anaemic patients with cancer: 2006 update
    • Bokemeyer C, Aapro MS, Courdi A, et al. EORTC guidelines for the use of erythropoietic proteins in anaemic patients with cancer: 2006 update. Eur J Cancer 2007; 43:258-270.
    • (2007) Eur J Cancer , vol.43 , pp. 258-270
    • Bokemeyer, C.1    Aapro, M.S.2    Courdi, A.3
  • 16
    • 39149121539 scopus 로고    scopus 로고
    • Effect of once-weekly epoetin beta on survival in patients with metastatic breast cancer receiving anthracycline-and/or taxane-based chemotherapy: Results of the Breast Cancer-Anemia and the Value of Erythropoietin (BRAVE) study
    • Aapro M, Leonard RC, Barnadas A, et al. Effect of once-weekly epoetin beta on survival in patients with metastatic breast cancer receiving anthracycline-and/or taxane-based chemotherapy: results of the Breast Cancer-Anemia and the Value of Erythropoietin (BRAVE) study. J Clin Oncol 2008; 26:592-598.
    • (2008) J Clin Oncol , vol.26 , pp. 592-598
    • Aapro, M.1    Leonard, R.C.2    Barnadas, A.3
  • 17
    • 38649128164 scopus 로고    scopus 로고
    • Phase III trial to evaluate the efficacy of maintaining hemoglobin levels above 12.0g/dL with erythropoietin vs above 10.0 g/dL without erythropoietin in anemic patients receiving concurrent radiation and cisplatin for cervical cancer
    • Thomas G, Ali S, Hoebers FJ, et al. Phase III trial to evaluate the efficacy of maintaining hemoglobin levels above 12.0g/dL with erythropoietin vs above 10.0 g/dL without erythropoietin in anemic patients receiving concurrent radiation and cisplatin for cervical cancer. Gynecol Oncol 2008; 108: 317-325.
    • (2008) Gynecol Oncol , vol.108 , pp. 317-325
    • Thomas, G.1    Ali, S.2    Hoebers, F.J.3
  • 18
    • 44249111891 scopus 로고    scopus 로고
    • Safety and efficacy of darbepoetin alpha in previously untreated extensive-stage small-cell lung cancer treated with platinum plus etoposide
    • Pirker R, Ramlau RA, Schuette W, et al. Safety and efficacy of darbepoetin alpha in previously untreated extensive-stage small-cell lung cancer treated with platinum plus etoposide. J Clin Oncol 2008; 26:2342-2349.
    • (2008) J Clin Oncol , vol.26 , pp. 2342-2349
    • Pirker, R.1    Ramlau, R.A.2    Schuette, W.3
  • 19
    • 40349103260 scopus 로고    scopus 로고
    • Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia
    • This is the latest and largest meta-analysis of the risks of VTE and mortality associated with ESA treatment
    • Bennett CL, Silver SM, Djulbegovic B, et al. Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. JAMA 2008; 299:914-924. This is the latest and largest meta-analysis of the risks of VTE and mortality associated with ESA treatment.
    • (2008) JAMA , vol.299 , pp. 914-924
    • Bennett, C.L.1    Silver, S.M.2    Djulbegovic, B.3
  • 20
    • 34047221511 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of erythropoietin in nonsmall-cell lung cancer with disease-related anemia
    • Wright JR, Ung YC, Julian JA, et al. Randomized, double-blind, placebo-controlled trial of erythropoietin in nonsmall-cell lung cancer with disease-related anemia. J Clin Oncol 2007; 25:1027-1032.
    • (2007) J Clin Oncol , vol.25 , pp. 1027-1032
    • Wright, J.R.1    Ung, Y.C.2    Julian, J.A.3
  • 21
    • 34547120946 scopus 로고    scopus 로고
    • Expression and function of erythro-poietin receptors in tumors: Implications for the use of erythropoiesis-stimulating agents in cancer patients
    • Sinclair AM, Todd MD, Forsythe K, et al. Expression and function of erythro-poietin receptors in tumors: implications for the use of erythropoiesis-stimulating agents in cancer patients. Cancer 2007; 110:477-488.
    • (2007) Cancer , vol.110 , pp. 477-488
    • Sinclair, A.M.1    Todd, M.D.2    Forsythe, K.3
  • 22
    • 34249056816 scopus 로고    scopus 로고
    • Are erythropoietin receptors expressed in tumors? Facts and fiction - more careful studies are needed
    • Agarwal N, Gordeuk VR, Prchal JT. Are erythropoietin receptors expressed in tumors? Facts and fiction - more careful studies are needed. J Clin Oncol 2007; 25:1813-1814.
    • (2007) J Clin Oncol , vol.25 , pp. 1813-1814
    • Agarwal, N.1    Gordeuk, V.R.2    Prchal, J.T.3
  • 23
    • 40849137929 scopus 로고    scopus 로고
    • Erythropoietin receptor transcription is neither elevated nor predictive of surface expression in human tumour cells
    • Sinclair AM, Rogers N, Busse L, et al. Erythropoietin receptor transcription is neither elevated nor predictive of surface expression in human tumour cells. Br J Cancer 2008; 98:1059-1067.
    • (2008) Br J Cancer , vol.98 , pp. 1059-1067
    • Sinclair, A.M.1    Rogers, N.2    Busse, L.3
  • 24
    • 36849026097 scopus 로고    scopus 로고
    • Erythropoietin treatment of human ovarian cancer cells results in enhanced signaling and a paclitaxel-resistant phenotype
    • Solar P, Feldman L, Jeong JY, et al. Erythropoietin treatment of human ovarian cancer cells results in enhanced signaling and a paclitaxel-resistant phenotype. Int J Cancer 2008; 122:281-288.
    • (2008) Int J Cancer , vol.122 , pp. 281-288
    • Solar, P.1    Feldman, L.2    Jeong, J.Y.3
  • 25
    • 35148857257 scopus 로고    scopus 로고
    • Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression
    • Hardee ME, Cao Y, Fu P, et al. Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. PLoS ONE 2007; 2:e549.
    • (2007) PLoS ONE , vol.2
    • Hardee, M.E.1    Cao, Y.2    Fu, P.3
  • 26
    • 34548161623 scopus 로고    scopus 로고
    • Expression of erythropoietin and its receptor in neuroblastomas
    • Sartelet H, Fabre M, Castaing M, et al. Expression of erythropoietin and its receptor in neuroblastomas. Cancer 2007; 110:1096-1106.
    • (2007) Cancer , vol.110 , pp. 1096-1106
    • Sartelet, H.1    Fabre, M.2    Castaing, M.3
  • 27
    • 34548094540 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptor coexpression is associated with poor survival in stage I nonsmall cell lung cancer
    • Saintigny P, Besse B, Callard P, et al. Erythropoietin and erythropoietin receptor coexpression is associated with poor survival in stage I nonsmall cell lung cancer. Clin Cancer Res 2007; 13:4825-4831.
    • (2007) Clin Cancer Res , vol.13 , pp. 4825-4831
    • Saintigny, P.1    Besse, B.2    Callard, P.3
  • 28
    • 60349102529 scopus 로고    scopus 로고
    • Predictive testing for erythropoietin induced tumor progression in head and neck cancer [abstract no.11007]
    • Blau CA, Miller CP, Lowe KA, et al. Predictive testing for erythropoietin induced tumor progression in head and neck cancer [abstract no.11007]. J Clin Oncol 2008; 26.
    • (2008) J Clin Oncol , pp. 26
    • Blau, C.A.1    Miller, C.P.2    Lowe, K.A.3
  • 29
    • 55749086268 scopus 로고    scopus 로고
    • Tumor progression and mortality associated with administration of erythropoiesis stimulating agents (ESAs) to cancer patients: Is toxicity due to ESAs or elevated hemoglobin (Hgb) levels? [abstract no.11115]
    • Kuykendal A, Bennett CL, McKoy JM, et al. Tumor progression and mortality associated with administration of erythropoiesis stimulating agents (ESAs) to cancer patients: is toxicity due to ESAs or elevated hemoglobin (Hgb) levels? [abstract no.11115]. J Clin Oncol 2008; 26.
    • (2008) J Clin Oncol , pp. 26
    • Kuykendal, A.1    Bennett, C.L.2    McKoy, J.M.3
  • 30
    • 43049157887 scopus 로고    scopus 로고
    • New limits advised for anemia drugs
    • Mitka M. New limits advised for anemia drugs. JAMA 2008; 299:2016.
    • (2008) JAMA , vol.299 , pp. 2016
    • Mitka, M.1
  • 31
    • 41449118498 scopus 로고    scopus 로고
    • Tanne JH. FDA committee recommends restricting use of antianaemia drug in cancer. BMJ 2008; 336:632. Report of the most recent ODAC meeting regarding the use of ESAs in cancer patients.
    • Tanne JH. FDA committee recommends restricting use of antianaemia drug in cancer. BMJ 2008; 336:632. Report of the most recent ODAC meeting regarding the use of ESAs in cancer patients.
  • 32
    • 55749099543 scopus 로고    scopus 로고
    • accessed August 14, 2008
    • http://www.emea.europa.eu/pdfs/human/press/pr/33396308en.pdf, accessed August 14, 2008.
  • 33
    • 55749106460 scopus 로고    scopus 로고
    • accessed August 14, 2008
    • http://www.fda.gov/cder/drug/infopage/RHE/default.htm, accessed August 14, 2008.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.