Lack of an association between GHR exon 3 polymorphism and diabetic nephropathy in the Genetics of Kidneys in Diabetes (GoKinD) population

Diabetologia

Volumn 51, Issue 12, 2008, Pages 2333-2334

  Gu, H F ^a   Efendic, S ^a   Brismar, K ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Diabetic nephropathy; Exon 3 polymorphism; Growth hormone receptor; Type 1 diabetes

Indexed keywords

CHOLESTEROL; CREATININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; HIGH DENSITY LIPOPROTEIN; RENIN;

ALBUMINURIA; BODY MASS; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DIASTOLIC BLOOD PRESSURE; DNA POLYMORPHISM; EXON; GENE FREQUENCY; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KNOCKOUT MOUSE; LETTER; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHENOTYPE; PLASMA RENIN ACTIVITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEINURIA; SYSTOLIC BLOOD PRESSURE;

DIABETIC NEPHROPATHIES; EXONS; HUMANS; POLYMORPHISM, GENETIC; RECEPTORS, SOMATOTROPIN;

EID: 55649115755     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-1145-2     Document Type: Letter

References (11)

1. C Dos Santos L Essioux C Teinturier 2004 A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone Nat Genet 36 720 724
2. A Carrascosa L Audí M Fernández-Cancio 2008 The exon 3-deleted/full-length growth hormone receptor polymorphism did not influence growth response to growth hormone therapy over two years in prepubertal short children born at term with adequate weight and length for gestational age J Clin Endocrinol Metab 93 764 70
3. M Horan V Newsway MD Yasmin Lewis 2006 Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke Hum Genet 119 527 540
4. RJ Strawbridge L Kärvestedt C Li 2007 GHR exon 3 polymorphism: Association with type 2 diabetes mellitus and metabolic disorder Growth Horm IGF Res 17 392 398
5. GR Reddy MJ Pushpanathan RF Ransom 2007 Identification of the glomerular podocyte as a target for growth hormone action Endocrinology 148 2045 2055
6. A Flyvbjerg 2004 The role of growth hormone in the pathogenesis of diabetic kidney disease Pediatr Endocrinol Rev 3 Suppl 525 529
7. E Egecioglu IJ Andersson E Bollano 2007 Growth hormone receptor deficiency in mice results in reduced systolic blood pressure and plasma renin, increased aortic eNOS expression, and altered cardiovascular structure and function Am J Physiol Endocrinol Metab 292 1418 1425
8. PW Mueller JJ Rogus PA Cleary 2006 Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes J Am Soc Nephrol 17 1782 1790
9. KG Alberti P Zimmet 1998 Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation Diabetic Med 15 539
10. The Juvenile Diabetes Research Foundation International. About the GoKinD Study. Available from http://www.jdrf.org/index.cfm?fuseaction=home. viewPage&page_id=B9C33021-1321-C834-0382E079E7865807, accessed 4 August 2008
11. J Pantel K Machinis ML Sobrier 2000 Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution J Biol Chem 275 18664 18669