Crucial role of peripheral κ-opioid receptors in a model of periodontal disease in rats

Journal of Periodontal Research

Volumn 43, Issue 6, 2008, Pages 730-736

  Pacheco, C M F ^b   Queiroz Junior, C M ^b   Maltos, K L M ^b   Caliari, M V ^b   Pacheco, D F ^b   Duarte, I D G ^b   Francischi, J N ^a,b  

^a 6627 Campus Pampulha ^*  (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Animal model; Inflammation; Opioid; Periodontal disease

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; DELTA OPIATE RECEPTOR; DRUG DERIVATIVE; KAPPA OPIATE RECEPTOR; MORPHINE; NALTREXONE; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST; NORBINALTORPHIMINE;

ANIMAL; ARTICLE; CHRONIC PERIODONTITIS; DISEASE MODEL; DRUG ANTAGONISM; DRUG POTENTIATION; MALE; PATHOPHYSIOLOGY; PERIPHERAL NERVOUS SYSTEM; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS, OPIOID; ANIMALS; CHRONIC PERIODONTITIS; DISEASE MODELS, ANIMAL; MALE; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; PERIPHERAL NERVOUS SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA;

EID: 55649113522     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2008.01102.x     Document Type: Article

References (38)

1. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000 1997 14 : 216 248.
2. Fox CH. New considerations in the prevalence of periodontal disease. Curr Opin Dent 1992 2 : 5 11.
3. Van Der Velden U. Effect of age on the periodontium. J Clin Periodontol 1984 11 : 281 294.
4. Johnson-Leong C, Patel G, Messieha Z. The relationship between coronary artery disease and periodontal disease. Dent Today 2003 22 : 100 105.
5. Matthews DC. The relationship between diabetes and periodontal disease. J Can Dent Assoc 2002 68 : 161 164.
6. Boggess KA, Moss K, Madianos P, Murtha AP, Beck J, Offenbacher S. Fetal immune response to oral pathogens and risk for preterm birth. Am J Obstet Gynocol 2005 193 : 1121 1126.
7. Reddy MS, Geurs NC, Gunsolley JC. Periodontal host modulation with antiproteinase, anti-inflammatory, and bone-sparing agents. A systematic review. Ann Periodontol 2003 8 : 12 37.
8. Walker JS, Wilson JL, Binder W, Scott C, Carmody JJ. The anti-inflammatory effects of opioids: their possible relevance to the pathophysiology and treatment of rheumatoid arthritis. Rheum Arthitis ID Res Alert 1997 1 : 291 299.
9. Mudie AS, Holland GR. Local opioids in the inflamed dental pulp. J Endod 2006 32 : 319 323.
10. Pacheco CMF, Queiroz-Junior CM, Maltos KLM, Rocha OA, Caliari MV, Francischi JN. Local opioids in a model of periodontal disease in rats. Arch Oral Biol 2007 52 : 677 683.
11. Machelska H, Schopohl JK, Mousa SA, Labuz D, Schäffer M, Stein C. Different mechanisms of intrinsic pain inhibition in early and late inflammation. J Neuroimmunol 2003 141 : 30 39.
12. Zöllner C, Shaquira MA, Bopaiah CP, Mousa S, Stein C, Schäfer M. Painful inflammation-induced increase in μ-opioid receptor binding and G-protein coupling in primary afferent neurons. Mol Pharmacol 2003 64 : 202 210.
13. Jiménez N, Puig MM, Pol O. Anti-exudative effects of opioids and expression of κ- and δ-opioid receptors during intestinal inflammation in mice: involvement of nitric oxide. J Pharmacol Exp Ther 2006 316 : 261 270.
14. Gutstein HB, Akil H. Opioid analgesics. In : Goodman & Gilman's The Pharmacological Basis of Therapeutics. Brunton LL, Lazo JS, Parker KL, eds. New York : McGraw Hill, 2005 : 547 590.
15. Walker JS, Chandler AK, Wilson JL, Day RO. Effect of mu-opioids morphine and buprenorphine on the development of adjuvant arthritis in rats. Inflamm Res 1996 45 : 557 563.
16. Binder W, Walker JS. Effect of the peripherally selective κ-opioid agonist, asimadoline, on adjuvant arthritis. Br J Pharmacol 1998 124 : 647 654.
17. Green PG, Levine JD. Delta- and kappa-opioid agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat. Neuroscience 1992 49 : 129 133.
18. Sallay K, Sanavi F, Ring I, Pharm P, Behling UH, Nowotny A. Alveolar bone destruction in the immunosuppressed rat. J Periodont Res 1982 17 : 263 274.
19. Maltos KL, Menezes GB, Caliari MV et al. Vascular and cellular responses to pro-inflammatory stimuli in rat dental pulp. Arch Oral Biol 2004 49 : 443 450.
20. Queiroz-Junior CM, Pacheco CMF, Maltos KLM, Caliari MV, Duarte IDG, Francischi JN. Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats. J Periodont Res 2008 in press.
21. Randall LD, Sellito JJ. A method for measurement of analgesic activity on inflamed tissues. Arch Int Pharmacol 1957 113 : 233 249.
22. + channels. Eur J Pharmacol 2005 512 : 23 28.
23. Taub DD, Eisenstein TK, Geller EB, Adler MW. Immunomodulatory activity of μ- and κ-selective opioid agonists. Proc Natl Acad Sci USA 1991 88 : 360 364.
24. Radulović J, Miljević C, Djergović D et al. Opioid receptor-mediated suppression of humoral immune response in vivo and in vitro: involvement of κ opioid receptors. J Neuroimmunol 1995 57 : 55 62.
25. Mansour A, Fox CA, Burke S et al. Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. J Comp Neurol 1994 350 : 412 438.
26. Sharp BN, Roy S, Bidlack JM. Evidence for opioid receptors on cells involved in host defense and the immune system. J Neuroimmunol 1998 83 : 45 56.
27. Cadet P, Bilfinger TV, Fimiani C, Peter D, Stefano GB. Human vascular and cardiac endothelia express mu opiate receptor transcripts. Endothelium 2000 7 : 185 191.
28. Pérez-Castrillón JL, Olmos JM, Gómez JJ et al. Expression of opioid receptors in osteoblast-like MG-63 cells, and effects of different opioid agonists on alkaline phosphatase and osteocalcin secretion by these cells. Neuroendocrinology 2000 72 : 187 194.
29. Belkowski SM, Alicea C, Eisenstein TK, Adler MW, Rogers TJ. Inhibition of interleukin-1 and tumor necrosis factor-α synthesis following treatment of macrophages with the κ-opioid agonist U50,488H. J Pharmacol Exp Ther 1995 273 : 1491 1496.
30. Pfeilschifter J, Chenu C, Bird A, Mundy GR, Roodman GD. Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclast-like cells in vitro. J Bone Miner Res 1989 4 : 113 118.
31. Delima AJ, Karatzas S, Amar S, Graves DT. Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists. Infect Dis 2002 186 : 511 516.
32. Oates TW, Graves DT, Cochran DL. Clinical, radiographic and biochemical assessment of IL-1/TNF-α antagonist inhibition of bone loss in experimental periodontitis. J Clin Periodontol 2002 29 : 137 143.
33. Barber A. μ- and κ-opioid receptor agonists produce peripheral inhibition of neurogenic plasma extravasation in rat skin. Eur J Pharmacol 1993 236 : 113 120.
34. Györfi A, Fazekas A, Suba Zs, Ender F, Rosivall L. Neurogenic component in ligature-induced periodontitis in the rat. J Clin Periodontol 1994 21 : 601 605.
35. Pol O, Puig MM. Expression of opioid receptors during peripheral inflammation. Curr Top Med Chem 2004 4 : 51 61.
36. Schäffer M, Imai Y, Uhl GR, Stein C. Inflammation enhances peripheral μ-opioid analgesia, but not μ-opioid receptor transcription in dorsal root ganglia. Eur J Pharmacol 1995 279 : 165 169.
37. Pol O, Alameda F, Puig MM. Inflammation enhances μ-opioid receptor transcription and expression in mice intestine. Mol Pharmacol 2001 60 : 894 900.
38. Wilson JL, Naynar V, Walker JS. The site of anti-arthritic action of the κ-opioid, U-50,488H, in adjuvant arthritis: importance of local administration. Br J Pharmacol 1996 118 : 1754 1760.