ABCA1 gene mutations, HDL cholesterol levels, and risk of ischemic heart disease

JAMA

Volumn 300, Issue 17, 2008, Pages 1997-1998

  Brunham, Liam R ^a   Kastelein, John J P ^b   Hayden, Michael R ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; ABC TRANSPORTER;

ALLELE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; ISCHEMIC HEART DISEASE; LETTER; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; BLOOD; GENETICS; HEART MUSCLE ISCHEMIA; MUTATION; NOTE;

ATP-BINDING CASSETTE TRANSPORTERS; CHOLESTEROL, HDL; HUMANS; MUTATION; MYOCARDIAL ISCHEMIA;

EID: 55549148746     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2008.539     Document Type: Letter

References (5)

1. Frikke-Schmidt R, Nordestgaard BG, Stene MC, et al. Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. JAMA. 2008;299(21):2524-2532.
2. Singaraja RR, Visscher H, James ER, et al. Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro. Circ Res. 2006;99(4):389-397.
3. Brunham LR, Singaraja RR, Hayden MR. Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis. Annu Rev Nutr. 2006;26:105-129.
4. Frikke-Schmidt R, Nordestgaard BG, Schnohr P, Steffensen R, Tybjærg-Hansen A. Mutation in ABCA1 predicted risk of ischemic heart disease in the Copenhagen City Heart Study Population. J Am Coll Cardiol. 2005;46(8):1516-1520.
5. Frikke-Schmidt R, Nordestgaard BG, Jensen GB, Steffensen R, Tybjærg-Hansen A. Genetic variation in ABCA1 predicts ischemic heart disease in the general population. Arterioscler Thromb Vasc Biol. 2008;28(1):180-186.