Ultrasound assisted thrombolysis in acute ischaemic stroke: Preliminary experience in Singapore

Annals of the Academy of Medicine Singapore

Volumn 37, Issue 9, 2008, Pages 778-782

  Sharma, Vijay K ^a   Rathakrishnan, Rahul ^a   Ong, Benjamin K C ^a   Chan, Bernard P L ^a  

^a NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

Acute ischaemic stroke; Thrombolysis; Transcranial doppler

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; CASE REPORT; CEREBROVASCULAR ACCIDENT; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; DOPPLER ECHOGRAPHY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MALE; OCCLUSIVE CEREBROVASCULAR DISEASE; SINGAPORE; TREATMENT OUTCOME; ULTRASOUND THERAPY;

EID: 55549144028     PISSN: 03044602     EISSN: 29724066     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581-7.
2. HSA Singapore communication CDA (PER) 102718 dated September 20, 2004.
3. Thomassen L, Waje-Andreassen U, Naess H, Aarseth J, Russell D. Doppler ultrasound and clinical findings in patients with acute ischemic stroke treated with intravenous thrombolysis. Eur J Neurol 2005;12: 462-5.
4. Alexandrov AV, Demchuk AM, Felberg RA, Christou I, Barber PA, Burgin WS, et al. High rate of complete recanalization and dramatic clinical recovery during TPA infusion when continuously monitored by 2 MHz transcranial Doppler monitoring. Stroke 2000;31:610-4.
5. Braaten JV, Goss RA, Francis CW. Ultrasound reversibly disaggregates fibrin fibers. Thromb Haemost 1997;78:1063-8.
6. Kondo I, Mizushige K, Ueda T, Masugata H, Ohmori K, Matsuo H. Histological observations and the process of ultrasound contrast agent enhancement of tissue plasminogen activator thrombolysis with ultrasound exposure. Jpn Circ J 1999;63:478-84.
7. Suchkova V, Siddiqi FN, Carstensen EL, Dalecki D, Child S, Francis CW, et al. Enhancement of fibrinolysis with 40-kHz ultrasound. Circulation 1998;98:1030-5.
8. Alexandrov AV, Felberg RA, Demchuk AM, Christou I, Burgin WS, Malkoff M, et al. Deterioration following spontaneous improvement: sonographic findings in patients with acutely resolving symptoms of cerebral ischemia. Stroke 2000;31:915-9.
9. Alexandrov AV, Molina CA, Grotta JC, et al for the CLOTBUST Investigators. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med 2004;351:2170-8.
10. Alexandrov AV, Wojner AW, Grotta JC; CLOTBUST Investigators. CLOTBUST: design of a randomized trial of ultrasound-enhanced thrombolysis for acute ischemic stroke. J Neuroimaging 2004;14:108-12.
11. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993;24:35-41.
12. Adams HP Jr, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, et al; American Heart Association/American Stroke Association Stroke Council; American Heart Association/American Stroke Association Clinical Cardiology Council; American Heart Association/American Stroke Association Cardiovascular Radiology and Intervention Council; Atherosclerotic Peripheral Vascular Disease Working Group; Quality of Care Outcomes in Research Interdisciplinary Working Group. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Circulation 2007;115:e478-534.
13. Alexandrov AV, Demchuk A, Wein T, Grotta JC. The yield of transcranial Doppler in acute cerebral ischemia. Stroke 1999;30:1605-9.
14. Demchuk AM, Christou I, Wein TH, Felberg RA, Malkoff M, Grotta JC, et al. Accuracy and criteria for localizing arterial occlusion with transcranial Doppler. J Neuroimaging 2000;10:1-12.
15. Burgin WS, Malkoff M, Felberg RA, Demchuk AM, Christou I, Grotta JC, et al. Transcranial doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke. Stroke 2000;31:1128-32.
16. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet 1998;352:1245-51.
17. Albers GW, Bates VE, Clark WM, Bell R, Verro P, Hamilton SA. Intravenous tissue-type plasminogen activator for treatment of acute stroke: the standard treatment with alteplase to reverse stroke (STARS) study. J Am Med Assoc 2000;283:1145-50.
18. Albers GW, Clark WM, Madden KP, Hamilton SA. ATLANTIS trial: results for patients treated within 3 hours of stroke onset. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. Stroke 2002;33:493-5.
19. Nandigam K, Narayan SK, Elangovan S, Dutta TK, Sethuraman KR, Das AK. Feasibility of acute thrombolytic therapy for stroke. Neurol India 2003;51:470-3.
20. Suwanwela NC, Phanthumchinda K, Likitjaroen Y. Thrombolytic therapy in acute ischemic stroke in Asia: the first prospective evaluation. Clin Neurol Neurosurg 2006;108:549-52.
21. Yamaguchi T, Mori E, Minematsu K, Nakagawara J, Hashi K, Saito I, et al; Japan Alteplase Clinical Trial (J-ACT) Group. Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical Trial (J-ACT). Stroke 2006;37:1810-5.
22. Ueshima S, Matsuo O. The differences in thrombolytic effects of administrated recombinant t-PA between Japanese and Caucasians. Thromb Haemost 2002;87:544-6.
23. Yamaguchi K, Hori S, Nogawa S, Tanahashi N, Fukuuchi Y, Aikawa N. Thrombolysis candidates for the treatment of stroke at an emergency department in Japan. Acad Emerg Med 2002;9:754-8.
24. Suwanwela NC, Phanthumchinda K, Suwanwela N, Tantivatana J, Janchai A. Thrombolytic treatment for acute ischemic stroke: a 2 year-experience at King Chulalongkorn Memorial Hospital. J Med Assoc Thai 2001;84:S428-S436.
25. Trubestein R, Bernard HR, Etzel F., Sobbe A, Cremer A, Stumpff U. Thrombolysis by ultrasound. Clin Sci Mol Med 1976;51:697-8.
26. Lauer CG, Burge R, Tang DB, Bass BG, Gomez ER, Alving BM. Effect of ultrasound on tissue-type plasminogen activator-induced thrombolysis. Circulation 1992;86:1257-64.
27. Behrens S, Daffertshofer M, Spiegel D, Hennerici M. Low-frequency, low-intensity ultrasound accelerates thrombolysis through the skull. Ultrasound Med Biol 1999;25:269-73.
28. Daffertshofer M, Hennerici M. Ultrasound in the treatment of ischemic stroke. Lancet Neurol 2003;2:283-90.
29. Daffertshofer M, Gass A, Ringleb P, Sitzer M, Sliwka U, Els T, et al. Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia. Stroke 2005;36:1441-6.
30. Demchuk AM, Burgin WS, Christou I, Felberg RA, Barber PA, Hill MD, et al. Thrombolysis in Brain Ischemia (TIBI) TCD flow grades predict clinical severity, early recovery and mortality in intravenous TPA treated patients. Stroke 2001;32:89-93.
31. Sloan MA, Alexandrov AV, Tegeler CH, Spencer MP, Caplan LR, Feldmann E, et al. Assessment: transcranial Doppler ultrasonography: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2004;62:1468-81.
32. Tsivgoulis G, Sharma VK, Lao AY, Malkoff MD, Alexandrov AV. Validation of transcranial Doppler with computed tomography angiography in acute cerebral ischemia. Stroke 2007;38:1245-9.
33. Rathakrishnan R, Berne YI, Quek KK, Hong CS, Ong BK, Chan BP, et al. Validation of transcranial Doppler with CT angiography in cerebral ischaemia: a preliminary pilot study in Singapore. Ann Acad Med Singapore 2008;37:402-5.
34. Rathakrishnan R, Sharma Vijay K, Seet RCS, Chan BPL, Ong BKC. Comparison of transcranial Doppler and magnetic resonance angiography in the assessment of intracranial vasculature in acute ischemic stroke. Presented at XVIII Wold Congress of Neurology, Sydney; November 2005.