Adrenoreceptors, platelet reactivity and clopidogrel resistance

Thrombosis and Haemostasis

Volumn 100, Issue 5, 2008, Pages 729-730

  Xiang, Yao Zu ^a,b  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; CANGRELOR; CLOPIDOGREL; COLLAGEN; CYTOCHROME P450; DOPAMINE RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; G PROTEIN COUPLED RECEPTOR; PADGEM PROTEIN; PURINERGIC P2Y12 RECEPTOR; RISTOCETIN; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ARTERY DISEASE; CLINICAL TRIAL; CORONARY ARTERY DISEASE; DRUG EFFECT; DRUG RESISTANCE; EDITORIAL; HEMOSTASIS; HUMAN; LOW DRUG DOSE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STABLE ANGINA PECTORIS; STROKE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOSIS; THROMBOSIS PREVENTION;

ASPIRIN; BLOOD PLATELETS; CORONARY ARTERY DISEASE; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; HUMANS; NOREPINEPHRINE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, PURINERGIC P2; TICLOPIDINE; TREATMENT FAILURE;

EID: 55549123572     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH08-09-0608     Document Type: Editorial

References (17)

1. Xiang YZ, Xia Y, Gao XM, et al. Platelet activation, and antiplatelet targets and agents: current and novel strategies. Drugs 2008; 68: 1647-1664.
2. Gladding P, Webster M, Ormiston J, et al. Antiplatelet drug nonresponsiveness. Am Heart J 2008; 155: 591-599.
3. Béres BJ, Tóth-Zsámboki E, Vargová K, et al. Analysis of platelet alpha-2 adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy. Thromb Haemost 2008; 100: 829-836.
4. Aleil B, Ravanat C, Cazenave JP, et al. Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost 2005; 3: 85-92.
5. Cattaneo M. Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection. J Thromb Haemost 2007; 5: 230-237.
6. Xiang Y-Z, Kang LY, Gao XM, et al, Strategies for antiplatelet targets and agents, Thromb Res 2008; prepub online doi:10.1016/j.thromres.2008.05.003.
7. Campbell CL, Steinhubl SR. Variability in response to aspirin: do we understand the clinical relevance?. J Thromb Haemost 2005; 3: 665-669.
8. De Miguel A, Ibanez B, Badimón JJ. Clinical implications of clopidogrel resistance. Thromb Haemost 2008; 100: 196-203.
9. von Beckerath N, von Beckerath O, Koch W, et al. P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose. Blood Coagul Fibrinolysis 2005; 16: 199-204.
10. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease. Thromb Res 2005; 116: 491-497.
11. Anfossi G, Trovati M. Role of catecholamines in platelet function pathophysiological and clinical significance. Eur J Clin Invest 1996; 26: 353-370.
12. Maayani S, Schwarz T, Craddock-Royal B, et al. Activation of the alpha(2A)-adrenoceptor mediates deceleration of the deaggregation component of the response to ADP or 5-HT in human platelets in vitro. Platelets 2001; 12: 359-375.
13. Yee DL, Sun CW, Bergeron AL, et al. Aggregometry detects platelet hyperreactivity in healthy individuals. Blood 2005; 106: 2723-2729.
14. Yee DL, Bergeron AL, Sun CW, et al. Platelet hyperreactivity generalizes to multiple forms of stimulation. J Thromb Haemost 2006; 4: 2043-2050.
15. Pozgajová M, Sachs UJ, Hein L, et al. Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor. Blood 2006; 108: 510-514.
16. Offermanns S. Activation of platelet function through G protein-coupled receptors. Circ Res 2006; 99: 1293-1304.
17. Nakahashi TK, Kambayashi J, Nakamura T, et al. Platelets in nonresponders to epinephrine stimulation showed reduced response to ADP. Thromb Res 2001; 104: 127-135.