Vitamin A-guided siRNAs targeting a collagen chaperone can reverse experimental cirrhosis

Journal of Hepatology

Volumn 49, Issue 6, 2008, Pages 1085-1087

  Rosenbaum, Jean ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; CHAPERONE; COLLAGEN; DIMETHYLNITROSAMINE; GLYCOPROTEIN; GLYCOPROTEIN GP 46; LIPOSOME; RETINOL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT LIGATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EXPERIMENTAL STUDY; FIBROGENESIS; IN VIVO STUDY; INNATE IMMUNITY; LIVER CIRRHOSIS; LIVER FIBROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL;

EID: 55549116303     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.09.009     Document Type: Article

References (9)

1. Sato Y., Murase K., Kato J., Kobune M., Sato T., Kawano Y., et al. Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol 26 (2008) 431-442
2. Gonzalo T., Beljaars L., van de Bovenkamp M., Temming K., van Loenen A.M., Reker-Smit C., et al. Local inhibition of liver fibrosis by specific delivery of a platelet-derived growth factor kinase inhibitor to hepatic stellate cells. J Pharmacol Exp Ther 321 (2007) 856-865
3. Schoemaker M.H., Rots M.G., Beljaars L., Ypma A.Y., Jansen P.L., Poelstra K., et al. PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. Mol Pharm 5 (2008) 399-406
4. Nagata K. Hsp47: a collagen-specific molecular chaperone. Trends Biochem Sci 21 (1996) 22-26
5. Masuda H., Fukumoto M., Hirayoshi K., and Nagata K. Coexpression of the collagen-binding stress protein HSP47 gene and the alpha 1(I) and alpha 1(III) collagen genes in carbon tetrachloride-induced rat liver fibrosis. J Clin Invest 94 (1994) 2481-2488
6. Blomhoff R., Berg T., and Norum K.R. Transfer of retinol from parenchymal to stellate cells in liver is mediated by retinol-binding protein. Proc Natl Acad Sci USA 85 (1988) 3455-3458
7. Quadro L., Blaner W.S., Hamberger L., Novikoff P.M., Vogel S., Piantedosi R., et al. The role of extrahepatic retinol binding protein in the mobilization of retinoid stores. J Lipid Res 45 (2004) 1975-1982
8. Quadro L., Blaner W.S., Salchow D.J., Vogel S., Piantedosi R., Gouras P., et al. Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO J 18 (1999) 4633-4644
9. Kawaguchi R., Yu J., Honda J., Hu J., Whitelegge J., Ping P., et al. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science 315 (2007) 820-825