High rate of mutation K103N causing resistance to nevirapine in Indian children with acquired immunodeficiency syndrome

Indian Journal of Medical Microbiology

Volumn 26, Issue 4, 2008, Pages 372-374

  Sehgal, S ^a   Pasricha, N ^a   Singh, S ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Children with AIDS; Mutation K103N; Nevirapine

Indexed keywords

LAMIVUDINE; NEVIRAPINE; STAVUDINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL RESISTANCE; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; INDIA; MALE; SINGLE DRUG DOSE; STRUCTURAL GENE;

EID: 55549114032     PISSN: 02550857     EISSN: 19983646     Source Type: Journal    
DOI: 10.4103/0255-0857.43583     Document Type: Article

References (13)

1. Gulick RM, Mellors JW, Havlir D, Eron JJ, Gonzalez C, McMahon D, et al Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Eng J Med 1997;337:734-7.
2. Overview of AIDS in India. Available from: http://www.avert. org.aidsindia.htm. [cited on 2007 Jul].
3. Sehgal S, Datta U, Arora S, Pasricha N, Jamaes I, Singh S. Rising trend of pediatric AIDS in North India: Experience of a tertiary care centre. Ann Nat Acad Med Sci India 2007;43:79-86.
4. Boden D, Hurley A, Zhang L, Cao Y, Guo Y, Jones E, et al. HIV-1 drug resistance in newly infected individuals. JAMA 1999;282:1135-41.
5. Fixed drug combination to treat HIV cases. Available from: http://www.naco.nic.in. [cited in 2004].
6. Larder BA, Kellan P, Kemp SD. Zidovudine resistance predicted by direct detection of mutations in DNA from HIVinfected lymphocytes. AIDS 1991;5:137-44.
7. Sachdeva N, Sehgal S, Arora SK. Frequency of drug resistant variants of HIV coexistent with wild type in treatment naïve patients in India. MedGenMed 2005;7:68.
8. Farmer P. AIDS as a global emergency. Bull World Health Organ 2003;81:699.
9. Grant RM, Hecht FM, Warmerdam M, Liu L, Liegler T, Petropoulos CJ, et al. Time trends in primary HIV-1 drug resistance among recently infected persons. JAMA 2002;181-88.
10. Adje C, Cheingsong R, Roels TH, Maurice C, Djomand G, Verbiest W, et al. High prevalence of genotypic and phenotypic HIV-1 drug resistance strains among patients receiving antiretroviral therapy in Abidjan, Cote d .Ivoir. J Acquir Immune Defic Syndr 2001;26:501-6.
11. Flys T, Nissley DV, Claasen CW, Jones D, Shi C, Guay LA, et al. Sensitive drug resistance assays reveal long term persistence of HIV-1 variants with K 103N nevirapine (NVP) resistance mutations in some women and infants after a single dose nevirapine: HIV NET 012. J Infect Dis 2005;192:24-9.
12. Kurle SN, Gangakhedkar RR, Sen S, Hayatnagarkar SS, Tripathy SP, Paranjape RS. Emergence of NNRTI drug resistance mutations after a single dose of nevirapine in HIV 1 sub type C infected infants in India. AIDS Res Hum Retroviruses 2007;23:682-5.
13. What.s new in the PMTCT guidelines? Available from: http:// www.who/ int/hiv/mediacentre/fs_2006guidelines_pmtct/en. Update October 6 2008.