Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6189-6193

  Vendeville, Sandrine ^a   Nilsson, Magnus ^b   Kock, Herman de ^a   Lin, Tse I ^a   Antonov, Dmitry ^b   Classon, Björn ^b   Ayesa, Susana ^b   Ivanov, Vladimir ^b   Johansson, Per Ola ^b   Kahnberg, Pia ^b   Eneroth, Anders ^b   Wikstrom, Kristina ^b   Vrang, Lotta ^b   Edlund, Michael ^b   Lindström, Stefan ^b   Vreken, Wim Van de ^a   McGowan, David ^a   Tahri, Abdellah ^a   Hu, Lili ^a   Lenz, Oliver ^a   Delouvroy, Frederic ^a   Dooren, Marleen Van ^a   Kindermans, Natalie ^a   Surleraux, Dominique ^a   Wigerinck, Piet ^a   Rosenquist, Åsa ^b   Samuelsson, Bertil ^b   Simmen, Kenneth ^a   Raboisson, Pierre ^a   more..

^a TIBOTEC BVBA   (Belgium)

^b MEDIVIR AB   (Sweden)

Author keywords

Hepatitis C; Macrocycle; NS3; Serine protease

Indexed keywords

CILUPREVIR; MACROCYCLIC COMPOUND; N [3 AMINO 1 (CYCLOBUTYLMETHYL) 2,3 DIOXOPROPYL] 3 [2 (3 TERT BUTYLUREIDO) 3,3 DIMETHYL 1 OXOBUTYL] 6,6 DIMETHYL 3 AZABICYCLO[3.1.0]HEXANE 2 CARBOXAMIDE; NONSTRUCTURAL PROTEIN 3; PROTEINASE INHIBITOR; SERINE PROTEINASE; TELAPREVIR;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL LINE; CELL STRAIN CACO 2; CELL STRAIN HUH7; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LIPOPHILICITY; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; CARBAMATES; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; HEPACIVIRUS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROLINE; RATS; RATS, SPRAGUE-DAWLEY; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; RATTUS;

EID: 55549110737     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.004     Document Type: Article

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