Synthesis of 6-methyl-6H-indolo[3,2-c]isoquinoline and 6-methyl-6H-indolo[2,3-c]isoquinoline: two new unnatural isoquinoline isomers of the cryptolepine series

Tetrahedron

Volumn 64, Issue 51, 2008, Pages 11802-11809

  Van Baelen, Gitte ^a   Meyers, Caroline ^a   Lemière, Guy L F ^a   Hostyn, Steven ^a   Dommisse, Roger ^a   Maes, Louis ^a   Augustyns, Koen ^b   Haemers, Achiel ^b   Pieters, Luc ^b   Maes, Bert U W ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b Department of Pharmaceutical Sciences ^*  (Belgium)

Author keywords

Buchwald Hartwig reaction; C(sp2) H activation; Cryptolepines; Malaria; Nitrene insertion; Palladium; Plasmodium falciparum; Suzuki reaction

Indexed keywords

6 METHYL 6H INDOLO[2,3 C]ISOQUINOLINE; 6 METHYL 6H INDOLO[3,2 C]ISOQUINOLINE; 7H INDOLO[2,3 C]ISOQUINOLINE; ALKENE; BENZNIDAZOLE; BORONIC ACID DERIVATIVE; CHLOROQUINE; CRYPTOLEPINE; ISOCRYPTOLEPINE; ISONEOCRYPTOLEPINE; ISOQUINOLINE DERIVATIVE; LEAD; MELARSOPROL; MILTEFOSINE; NEOCRYPTOLEPINE; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; ARYLATION; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; IC 50; LEISHMANIA DONOVANI; METHYLATION; MOLECULAR INTERACTION; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; RAT; SUZUKI REACTION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

PLASMODIUM FALCIPARUM;

EID: 55549110034     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2008.08.116     Document Type: Article

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