Preventive effects of genistein on motor dysfunction following 6-hydroxydopamine injection in ovariectomized rats

Neuroscience Letters

Volumn 448, Issue 1, 2008, Pages 10-14

  Kyuhou, Shin ichi ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Estrogen activities; Isoflavone; Motor function; Parkinson's disease; Postmenopause

Indexed keywords

ANTIESTROGEN; ESTROGEN RECEPTOR; FULVESTRANT; GENISTEIN; ISOFLAVONE; OXIDOPAMINE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; FEMALE; FOREBRAIN; IMMUNOREACTIVITY; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NONHUMAN; OVARIECTOMY; PARKINSON DISEASE; POSTMENOPAUSE; PRIORITY JOURNAL; RAT; TASK PERFORMANCE; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADRENERGIC AGENTS; ANIMALS; APOMORPHINE; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXPLORATORY BEHAVIOR; FEMALE; GENISTEIN; MOTOR ACTIVITY; MOVEMENT DISORDERS; NEURONS; OVARIECTOMY; OXIDOPAMINE; PHYTOESTROGENS; PSYCHOMOTOR PERFORMANCE; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE 3-MONOOXYGENASE;

EID: 55549102259     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.10.045     Document Type: Article

References (23)

1. Agid Y. Parkinson's disease: pathophysiology. Lancet 337 (1991) 1321-1324
2. Carman L.S., Gage F.H., and Shults C.W. Partial lesion of the substantia nigra: relation between extent of lesion and rotational behavior. Brain Res. 553 (1991) 275-283
3. Chang H.C., Churchwell M.I., Delclos K.B., Newbold R.R., and Doerge D.R. Mass spectrometric determination of Genistein tissue distribution in diet-exposed Sprague-Dawley rats. J. Nutr. 130 (2000) 1963-1970
4. D'Astous M., Mendez P., Morissette M., Garcia-Segura L.M., and Di Paolo T. Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Mol. Pharmacol. 69 (2006) 1492-1498
5. Honda K., Shimohama S., Sawada H., Kihara T., Nakamizo T., Shibasaki H., and Akaike A. Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. J. Neurosci. Res. 64 (2001) 466-475
6. Kokubo Y., Iso H., Ishihara J., Okada K., Inoue M., and Tsugane S. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I. Circulation 116 (2007) 2553-2562
7. Leranth C., Roth R.H., Elsworth J.D., Naftolin F., Horvath T.L., and Redmond Jr. D.E. Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: implications for Parkinson's disease and memory. J. Neurosci. 20 (2000) 8604-8609
8. Linford N.J., and Dorsa D.M. 17beta-Estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigargin. Steroids 67 (2002) 1029-1040
9. Liu B., and Dluzen D.E. Oestrogen and nigrostriatal dopaminergic neurodegeneration: animal models and clinical reports of Parkinson's disease. Clin. Exp. Pharmacol. Physiol. 34 (2007) 555-565
10. Liu L.X., Chen W.F., Xie J.X., and Wong M.S. Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease. Neurosci. Res. 60 (2008) 156-161
11. Lundblad M., Andersson M., Winkler C., Kirik D., Wierup N., and Cenci M.A. Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease. Euro. J. Neurosci. 15 (2002) 120-132
12. Mueller S.O., Simon S., Chae K., Metzler M., and Korach K.S. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells. Toxicol. Sci. 80 (2004) 14-25
13. Murray H.E., Pillai A.V., McArthur S.R., Razvi N., Datla K.P., Dexter D.T., and Gillies G.E. Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females. Neuroscience 116 (2003) 213-222
14. Nakagawa H., Yamamoto D., Kiyozuka Y., Tsuta K., Uemura Y., Hioki K., Tsutsui Y., and Tsubura A. Effects of genistein and synergistic action in combination with eicosapentaenoic acid on the growth of breast cancer cell lines. J. Cancer Res. Clin. Oncol. 126 (2000) 448-454
15. Olsson M., Nikkhah G., Bentlage C., and Bjorklund A. Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J. Neurosci. 15 (1995) 3863-3875
16. Quesada A., Lee B.Y., and Micevych P.E. PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease. Dev. Neurobiol. 68 (2008) 632-644
17. Quesada A., Romeo H.E., and Micevych P. Distribution and localization patterns of estrogen receptor-beta and insulin-like growth factor-1 receptors in neurons and glial cells of the female rat substantia nigra: localization of ERbeta and IGF-1R in substantia nigra. J. Comp. Neurol. 503 (2007) 198-208
18. Rossouw J.E., Anderson G.L., Prentice R.L., LaCroix A.Z., Kooperberg C., Stefanick M.L., Jackson R.D., Beresford S.A., Howard B.V., Johnson K.C., Kotchen J.M., and Ockene J. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 288 (2002) 321-333
19. Schallert T., Fleming S.M., Leasure J.L., Tillerson J.L., and Bland S.T. CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacol. 39 (2000) 777-787
20. Shughrue P.J., Lane M.V., and Merchenthaler I. Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J. Comp. Neurol. 388 (1997) 507-525
21. Shulman L.M. Gender differences in Parkinson's disease. Gend. Med. 4 (2007) 8-18
22. Usui T. Pharmaceutical prospects of phytoestrogens. Endocr. J. 53 (2006) 7-20
23. Wu J., Oka J., Higuchi M., Tabata I., Toda T., Fujioka M., Fuku N., Teramoto T., Okuhira T., Ueno T., Uchiyama S., Urata K., Yamada K., and Ishimi Y. Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial. Metabolism 55 (2006) 423-433