17α-hydroxy-progesterone effects on cervical proinflammatory agents in women at risk for preterm delivery

American Journal of Perinatology

Volumn 25, Issue 8, 2008, Pages 503-506

  Facchinetti, Fabio ^a,b   Dante, Giulia ^a   Venturini, Paolo ^a   Paganelli, Simone ^a   Volpe, Annibale ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Dip Materno Infantile   (Italy)

Author keywords

17 hydroxyprogesterone caproate; Preterm delivery; Preterm labor; Proinflammatory agents

Indexed keywords

CYTOKINE; HYDROXYPROGESTERONE CAPROATE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; NITRATE; NITRITE; TUMOR NECROSIS FACTOR ALPHA; 17-ALPHA-HYDROXY-PROGESTERONE CAPROATE; PROGESTERONE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG RESPONSE; ECHOGRAPHY; FEMALE; GESTATIONAL AGE; HIGH RISK PREGNANCY; HUMAN; IMMUNOASSAY; INFLAMMATION; MAJOR CLINICAL STUDY; PREGNANT WOMAN; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; TOCOLYSIS; TRANSVAGINAL ECHOGRAPHY; URINALYSIS; UTERINE CERVIX CYTOLOGY; UTERINE CERVIX RIPENING; CHEMISTRY; COLORIMETRY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; PROSPECTIVE STUDY; SECRETION; UTERINE CERVIX;

ADULT; CERVICAL RIPENING; CERVIX UTERI; COLORIMETRY; CYTOKINES; FEMALE; HUMANS; HYDROXYPROGESTERONES; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; OBSTETRIC LABOR, PREMATURE; PREGNANCY; PROGESTERONE CONGENERS; PROSPECTIVE STUDIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 55449118403     PISSN: 07351631     EISSN: 10988785     Source Type: Journal    
DOI: 10.1055/s-0028-1085071     Document Type: Article

References (18)

1. Johnson JW, Austin KL, Jones GS, Davis GH, King TM. Efficacy of 17-α-hydroxyprogesterone caproate in the prevention of premature labor. N Engl J Med 1975;293: 675-680
2. Erny R, Pigne A, Prouvost C, et al. The effects of oral administration of progesterone for premature labor. Am J Obstet Gynecol 1986;154:525-529
3. Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH. Prevention of recurrent preterm delivery by alpha-hydroxyprogesterone caproate. N Engl J Med 2003; 348:2379-2385
4. Sfakianaki AK, Norwitz ER. Mechanisms of progesterone action in inhibiting prematurity. J Mat Fet Neonat Med 2006;19:763-72
5. Liggins G. Cervical ripening as an inflammatory reaction. In: Ellwood D, Anderson A, eds. The Cervix in Pregnancy and Labour. Clinical and Biochemical Investigations. Edinburgh: Churchill Livingstone; 1981
6. Facchinetti F, Venturini P, Blasi I, Giannella L. Changes in the cervical competence in preterm labour. BJOG 2005; 112(Suppl 1):23-27
7. Sennström MB, Ekman G, Westergren-Thorsson G, et al. Human cervical ripening, an inflammatory process mediated by cytokines. Mol Hum Reprod 2000;6:375-381
8. Facchinetti F, Paganelli S, Comitini G, Dante G, Volpe A. Cervical length changes during preterm cervical ripening: effects of 17α-hydroxy- progesterone caproate. Am J Obstet Gynecol 2007;196:453e1-453e4
9. Berghella V, Ness A, Bega G, Berghella M. Cervical sonography in women with symptoms of preterm labour. Obstet Gynecol Clin North Am 2005;32:383-396
10. Szekeres-Bartho J, Barakonyi A, Par G, Polgar B, Palcovics T, Szereday L. Progesterone as an immunomodulatory molecule. Int Immunopharmacol 2001;1:1037-1048
11. Cakmak H, Schatz F, Huang S-TJ, et al. Progestin suppresses thrombin- and interleukin-1β- induced interleukin-11 production in term decidual cells: implications for preterm delivery. J Clin Endocrinol Metab 2005;90:5279-5286
12. Elovitz MA, Mrinalini C. The use of progestational agents for preterm birth: lessons from a mouse model. Am J Obstet Gynecol 2006;195:1004-1010
13. Sadowsky DW, Adams KM, Gravett MG, Witkin SS, Novy MJ. Preterm labor is induced by intraamniotic infusions of interleukin-1β and tumor necrosis factor-α but not by interleukin-6 or interleukin-8 in a non human primate model. Am J Obstet Gynecol 2006;195:1578-1589
14. Tanaka Y, Narahara H, Takai N, Yoshimatsu J, Anai T, Miyakawa I. Interleukin-1 beta and interleukin-8 in cervicovaginal fluid during pregnancy. Am J Obstet Gynecol 1998;179:644-649
15. Edwards RK, Ferguson RJ, Duff P. The interleukin-1β + 3953 single nucleotide polymorphism: cervical protein concentration and preterm delivery risk. Am J Reprod Immunol 2006;55:259-264
16. Romero R, Brody DT, Oyarzun E, et al. Infection and labor. III. Interleukin-1: a signal for the onset of parturition. Am J Obstet Gynecol 1989;160:1117-1123
17. Fonseca EB, Celik E, Parra M, Singh M, Kypros H, Nicolaides KH. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med 2007; 357:462-469
18. Dodd JM, Flenady V, Cincotta R, Crowther CA. Prenatal administration of progesterone for preventing preterm birth. (Review) Cochrane Database Syst Rev 2006;25:CD004947