Lipoprotein(a) and its position among other risk factors of atherosclerosis

Physiological Research

Volumn 57, Issue 5, 2008, Pages 777-783

  Zlatohlávek, Lukáš ^a   Zidkova K ^a   Vrablik M ^a   Haas, T ^b   Prusikova M ^a   Svobodova H ^a   Ceska R ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Apolipoprotein(a); Atherosclerosis; Coronary heart disease; Gene polymorphisms; Lipoprotein(a); Risk factors

Indexed keywords

APOLIPOPROTEIN A; BIOLOGICAL MARKER; LIPID; LIPOPROTEIN A;

ADULT; AGED; ARTICLE; BLOOD; CORONARY ARTERY DISEASE; FEMALE; GENETIC POLYMORPHISM; GENETICS; HUMAN; HYPERTENSION; MALE; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROMOTER REGION; RISK ASSESSMENT; RISK FACTOR; SMOKING; UPREGULATION;

ADULT; AGED; APOPROTEIN(A); BIOLOGICAL MARKERS; CORONARY ARTERY DISEASE; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYPERTENSION; LIPIDS; LIPOPROTEIN(A); MALE; MIDDLE AGED; OVERWEIGHT; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RISK ASSESSMENT; RISK FACTORS; SMOKING; UP-REGULATION;

EID: 55449114502     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. BERGLUND L, RAMAKRISHNAN R: Lipoprotein(a): an elusive cardiovascular risk. Arterioscler Thromb Vasc Biol 24: 2219-2226, 2004.
2. BOERWINKLE E, LEFFERT CC, LIN J, LACKNER C, CHIESA G, HOBBS HH: Apolipoprotein(a) gene accounts for greater than 90 % of the variation in plasma lipoprotein(a) concentrations. J Clin Invest 90: 52-60, 1992.
3. BRAZIER L, TIRET L, LUC G, ARVEILER D, RUIDAVETS JB, EVANS A, CHAPMAN J, CAMBIEN F, THILLET J: Sequence polymorphisms in the apolipoprotein(a) gene and their association with lipoprotein(a) levels and myocardial infarction. The ECTIM study. Atherosclerosis 144: 323-333, 1999.
4. COHEN JC, CHIESA G, HOBBS HH: Sequence polymorphisms in the apolipoprotein(a) gene - evidence for dissociation between apolipoprotein(a) size and plasma lipoprotein(a) levels. J Clin Invest 91: 1630-1636, 1993.
5. EVANS RW, SHPILBERG O, SHATEN BJ, ALI S, KAMBOH MI, KULLER LH: Prospective association of lipoprotein(a) concentrations and apo(a) size with coronary heart disease among men in the Multiple Risk Factor Intervention Trial. J Clin Epidemiol 54: 51-57, 2001.
6. FOODY JM., MILBERG JA, PEARCE GL, SPRECHER DL: Lipoprotein(a) associated with coronary artery disease in older women: age and gender analysis. Atherosclerosis 153: 445-451, 2000.
7. HOLMER SR, HENGSTENBERG C, KRAFT HG, MAYER B, POLL M, KURZINGER S, FISCHER M, LOWEL H, KLEIN G, RIEGGER GA, SCHUNKERT H: Association of polymorphisms of the apolipoprotein(a) gene with lipoprotein(a) levels and myocardial infarction. Circulation 107: 696-701, 2003.
8. HOŘEJŠÍ B, ČEŠKA R: Apolipoproteins and atherosclerosis. Apolipoprotein E and apolipoprotein(a) as candidate genes of premature development of atherosclerosis. Physiol Res 49 (Suppl 1): S63-S69, 2000.
9. n polymorphism with coronary heart disease. Clin Chima Acta 309: 45-51, 2001.
10. KRAFT HG, KOCHL S, MENZEL HJ, SANDHOLZNER C, UTERMANN G: The apolipoprotein(a) gene: a transcribed hypervariable locus controlling plasma lipoprotein(a) concentration. Hum Genet 90: 220-230, 1992.
11. KRAFT HG, WINDEGGER M., MENZEL HJ, UTERMANN G: Significant impact of the +93 C/T polymorphism in the apolipoprotein(a) gene on Lp(a) concentrations in Africans but not in Caucasians: confounding effect of linkage disequilibrium. Hum Mol Genet 7: 257-264, 1998.
12. KOSCHINSKY ML, MARCOVINA SM: Structure-function relationships in apolipoprotein(a): insights into lipoprotein(a) assembly and pathogenicity. Curr Opin in Lipidol 15: 167-174, 2004.
13. LIPPI G, GUIDI G: Lipoprotein(a): an emerging cardiovascular risk factor. Crit Rev Clin Lab Sci 40: 1-42, 2003.
14. MARCOVINA SM, KOSCHINSKY M: A critical evaluation of the role of Lp(a) in cardiovascular disease: can Lp(a) be useful in risk assessment? Semin Vasc Med 2: 335-344, 2002.
15. MILLER SA, DYKES DD, POLESKY HF: A simple salting out procedure for DNA extraction from human nucleated cells. Nucl Acid Res 16: 1215, 1988.
16. PAULTRE F, PEARSON TA, WEIL HF, TUCK CH, MYERSON M, RUBIN J, FRANCIS CK, MARX HF, PHILBIN EF, REED RG, BERGLUND L: High levels of Lp(a) with a small apo(a) isoform are associated with coronary artery disease in African American and white men. Arterioscler Thromb Vasc Biol 20: 2619-2624, 2000.
17. PUCKEY LH, LAWN RM, KNIGHT BL: Polymorphisms in the apolipoprotein(a) gene and their relationship to allele size and plasma lipoprotein(a) concentration. Hum Mol Genet 6: 1099-1107, 1997.
18. RIFAI N, MA J, SACKS FM, RIDKER PM, HERNANDEZ WJ, STAMPFER MJ, MARCOVINA SM: Apolipoprotein(a) size and lipoprotein(a) concentration and future risk of angina pectoris with evidence of severe coronary atherosclerosis in men: Physicians Health Study. Clin Chem 50: 1364-1371, 2004.
19. SHAI I, RIMM EB, HANKINSON SE, CANNUSCIO C, CURAHN G, MANSON JE, RIFAI N, STAMPFER MJ, MA J: Lipoprotein(a) and coronary heart disease among women: beyond a cholesterol carrier? Eur Heart J 26: 1633-1639, 2005a.
20. SHAI I, SCHULZE MB, MANSON JE, STAMPFER MJ, RIFAI N, HU FB: A prospective study of lipoprotein(a) and risk of coronary heart disease among women with type 2 diabetes. Diabetologia 48: 2691-2692, 2005b.
21. SUZUKI K, KURIYAMA M, SAITO T, ICHINOSE A: Plasma lipoprotein(a) levels and expression of the apolipoprotein(a) gene are dependent on the nucleotide polymorphisms in its 5′-flanking region. J Clin Invest 99: 1361-1366, 1997.
22. STEIN JH, ROSENSON RS: Lipoprotein Lp(a) excess and coronary heart disease. Arch Intern Med 157: 1170-1176, 1997.
23. ŠULCOVÁ J, HILL M, MAŠEK Z, ČEŠKA R, NOVÁČEK A, HAMPL R, STÁRKA L: Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men. Physiol Res 50: 9-18, 2001.
24. TROMMSDORFF M, KOCHL S, LINGENHEL A, KRONENBERG F, DELPORT R, VERMAAK H, LEMMING L, KLAUSEN IC, FAERGEMAN O, UTERMANN G: A pentanucleotide repeat polymorphism in the 5′ control region of the apolipoprotein(a) gene is associated with lipoprotein(a) plasma concentration in Caucasians. J Clin Invest 96: 150-157, 1995.
25. WU JH, LEE IN: Studies of apolipoprotein(a) promoter from subjects with different plasma lipoprotein(a) concentrations. Clin Biochem 36: 241-246, 2003.
26. ZÍDKOVÁ K, KEBRDLOVÁ V, ZLATOHLÁVEK L, ČEŠKA R: Detection of variability in apo(a) gene transcription regulatory sequences using the DGGE method. Clin Chim Acta 376: 77-81, 2007.
27. ZYSOW BR, LINDAHL GE, WADE DP, Knight BL, LAWN RM: C/T polymorphism in the 5′ untranslated region of the apolipoprotein(a) gene introduces an upstream ATG and reduces in vitro translation. Arterioscler Thromb Vasc Biol 15: 58-64, 1995.