Trypanocidal activity of pimarane diterpenes from Viguiera arenaria (Asteraceae)

Phytotherapy Research

Volumn 22, Issue 10, 2008, Pages 1413-1415

  Ambrósio, Sérgio R ^a,b   Arakawa, Nilton S ^a   Esperandim, Viviane R ^a   De Albuquerque, Sérgio ^a   Da Costa, Fernando B ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE DE FRANCA   (Brazil)

Author keywords

Asteraceae; Pimarane diterpenes; Trypanocidal activity; Viguiera arenaria

Indexed keywords

DITERPENE; ENT 15 PIMARENE 8BETA,19 DIOL; ENT 8(14),15 PIMARADIENE 3BETA ACETOXY; PIMARANE DITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASTERACEAE; DRUG ISOLATION; DRUG STRUCTURE; IC 50; IN VITRO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT ROOT; THIN LAYER CHROMATOGRAPHY; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; ASTERACEAE; DITERPENES, ABIETANE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

ASTERACEAE; GENTIANA; TRYPANOSOMA CRUZI; VIGUIERA ARENARIA;

EID: 55449108710     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2512     Document Type: Article

References (11)

1. Ambrosio SR, Schorr K, Da Costa FB. 2004. Terpenoids of Viguiera arenaria (Asteraceae). Biochem Syst Ecol 32: 221-224.
2. Ambrosio SR, Tirapelli CR, Da Costa FB, De Oliveira AM. 2006. Kaurane and pimarane-type diterpenes from the Viguiera species inhibit vascular smooth muscle contractility. Life Sci 79: 925-933.
3. Ansell SM, Pegel KH, Taylor DAH. 1993. Diterpenes from the timber of 20 Erythroxylum species. Phytochemistry 32: 953-959.
4. Bastos JK, Albuquerque S, Silva MLA. 1999. Evaluation of the trypanocidal activity of lignans isolated from the leaves of Zanthoxylum naranjilo. Planta Med 65: 541-544.
5. Batista R, Humberto JL, Chiari E, De Oliveira AB. 2007. Synthesis and trypanocidal activity of ent-kaurane glycosides. Bioorg Med Chem 15: 381-391.
6. Da Costa FB, Vichnewiski W, Herz W. 1996. Diterpenes and synthetic derivatives from Viguiera aspillioides with trypanomicidal activity. Planta Med 62: 557-559.
7. Furtado NAJC, Duarte MCT, Albuquerque S, Mello C, Bastos JK. 2005. Improvement of trypanocidal metabolites production by Aspergillus fumigatus using neural networks. Microbiol Res 160: 141-148.
8. Molfetta FA, Bruni AT, Honório KM, Da Silva ABF. 2005. A structure-activity relationship study of quinine compounds with trypanocidal activity. Eur J Med Chem 40: 329-338.
9. Rubio J, Calderón JS, Flores A, Castro C, Céspedes CL. 2005. Trypanocidal activity of oleoresin and terpenoids isolated from Pinus oocarpa. Z Naturforsch 60: 711-716.
10. Takeara R, Albuquerque S, Lopes NP, Lopes JLC. 2003. Trypanocidal activity of Lychnophora staavioides Mart. (Vernonieae, Asteraceae). Phytomedicine 10: 490-493.
11. Tiuman TS, Ueda-Nakamura T, Cortez DAG, Filho BPD, Morgado-Díaz JA, de Souza W, Nakamura CV. 2005. Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium. Antimicrob Agents Chemother 49: 176-182.