Neocitreamicins I and II, novel antibiotics with activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci

Journal of Antibiotics

Volumn 61, Issue 7, 2008, Pages 457-463

  Peoples, Aaron J ^a   Zhang, Qibo ^a   Millett, William P ^a   Rothfeder, Mithra T ^a   Pescatore, Brian C ^a   Madden, Anne A ^a   Ling, Losee L ^a   Moore, Charles M ^a  

^a NovoBiotic Pharmaceuticals   (United States)

Author keywords

Citreamicin; MRSA; Neocitreamicin; Nocardia; VRE

Indexed keywords

ANTIBIOTIC AGENT; NATURAL PRODUCT; NEOCITREAMICIN I; NEOCITREAMICIN II; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; OXAZOLE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; DRUG ISOLATION; DRUG STRUCTURE; ENTEROCOCCUS FAECALIS; GRAM POSITIVE BACTERIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NOCARDIA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRUCTURE ANALYSIS; VANCOMYCIN RESISTANT ENTEROCOCCUS; ANTIBIOTIC RESISTANCE; CHEMISTRY; CULTURE MEDIUM; DRUG EFFECT; ENTEROCOCCUS; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METABOLISM; MICROBIOLOGY; PENICILLIN RESISTANCE; SPECTROSCOPY; STAPHYLOCOCCUS AUREUS;

ENTEROCOCCUS FAECALIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NOCARDIA; POSIBACTERIA;

ANTI-BACTERIAL AGENTS; CULTURE MEDIA; ENTEROCOCCUS; MASS SPECTROMETRY; METHICILLIN RESISTANCE; NOCARDIA; OXAZOLES; SOIL MICROBIOLOGY; SPECTRUM ANALYSIS; STAPHYLOCOCCUS AUREUS; VANCOMYCIN RESISTANCE;

EID: 55449100489     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.62     Document Type: Article

References (14)

1. Maiese WM, Lechevalier MP, Lechevalier HA, Korshalla J, Goodman J, Wildey MJ, Kuck N, Greenstein M. LL-E19085 alpha, a novel antibiotic from Micromonospora citrea: taxonomy, fermentation and biological activity. J Antibiot 42: 846-851 (1989)
2. Carter GT, Nietsche JA, Williams DR, Borders DB. Citreamicins, novel antibiotics from Micromonospora citrea: isolation, characterization, and structure determination. J Antibiot 43: 504-512 (1990)
3. Pearce CJ, Carter GT, Nietsche JA, Borders DB, Greenstein M, Maiese WM. The effect of methylation inhibitors on citreamicin biosynthesis in Micromonospora citrea. J Antibiot 44: 1247-1251 (1991)
4. Omura S, Iwai Y, Hinotozawa K, Takahashi Y, Kato J, Nakagawa A, Hirano A, Shimizu H, Haneda K. Cervinomycin A1 and A2, new antibiotics active against anaerobes, produced by Streptomyces cervinus sp. nov. J Antibiot 35: 645-652 (1982)
5. Lee T, Carter G, Borders DB. Structure determination of simaomicin α and β, extremely potent, novel anticoccidial agents produced by Actinomadura. J Chem Soc Commun 1989: 1771-1772 (1989)
6. Kobayashi K, Nishino C, Ohya J, Sato S, Mikawa T, Shiobara Y, Kodama M. Actinoplanones A and B, new cytotoxic polycyclic xanthones from Actinoplanes sp. J Antibiot 41: 502-511 (1988)
7. Kobayashi K, Nishino C, Ohya J, Sato S, Mikawa T, Shiobara Y, Kodama M. Actinoplanones C, D, E, F, and G, new cytotoxic polycyclic xanthones from Actinoplanes sp. J Antibiot 41: 502-511(1988)
8. Kaeberlein T, Lewis K, Epstein SS. Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment. Science 296: 1127-1129 (2002)
9. Baker GC, Smith JJ, Cowan DA. Review and re-analysis of domain-specific 16S primers. J Microbiol Meth 55: 541-555 (2003)
10. Shirling EB, Gottlieb D. Methods for characterizing Streptomyces species. Int J Syst Bacteriol 16: 313-340 (1966)
11. Atlas RM. Handbook of Microbiological Media, Ed. Parks LC, CRC Press, Boca Raton (1997)
12. Lewis K, Epstein SS, Kaeberlein S. Isolation and cultivation of microorganisms from natural environments and drug discovery based thereon. United States of America patent US 7011957 B2 (2006)
13. Blanchflower SE, Dorgan RJJ, Everett JR, Readshaw SA. An investigation of the stereochemistry of a 22,23-dioxygenated milbemycin. Tetrahedron Lett 29: 6645-6648 (1988)
14. Goegelman RT, Munguira E, Diez MMT, Sykes RS, Kong YL, Liesch JM, Helms GL, Turner JET. Anthelmintic milbemycin analogs of novel microorganisms. United States of America patent US 5290804 A (1994)