Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671+

Journal of Antibiotics

Volumn 61, Issue 7, 2008, Pages 464-473

  Fiedler, Hans Peter ^a   Dieter, Anke ^a   Guider, Tobias A M ^c   Kajahn, Inga ^c   Hamm, Andreas ^c   Brown, Ros ^b   Jones, Amanda L ^b   Goodfellow, Michael ^b   Müller, Werner E G ^d   Bringmann, Gerhard ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Antitumor activity; Chrysophanol; Fermentation; Octaketides; Streptomyces; Structure elucidation

Indexed keywords

CHRYSOPHANIC ACID DERIVATIVE; CHRYSOPHANOL GLUCURONIDE; GENOKETIDE A1; GENOKETIDE A2; POLYKETIDE; PRECHRYSOPHANOL GLUCURONIDE; UNCLASSIFIED DRUG; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC ANTIBIOTIC; CHRYSOPHANIC ACID; MACROLIDE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL STRAIN; DRUG ISOLATION; DRUG STRUCTURE; LYMPHOMA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TUMOR CELL LINE;

STREPTOMYCES; STREPTOMYCES SP.;

ANTHRAQUINONES; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; HUMANS; MACROLIDES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; STREPTOMYCES;

EID: 55449091859     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.63     Document Type: Article

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