Antiplatelet agents sarpogrelate and cilostazol affect experimentally- induced ventricular arrhythmias and mortality

Cardiovascular Toxicology

Volumn 8, Issue 3, 2008, Pages 127-135

  Barta, Judit ^a   Sanganalmath, Santosh K ^a   Kumamoto, Hideo ^a   Takeda, Nobuakira ^b   Édes, István ^c   Dhalla, Naranjan S ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Arrhythmias; Cilostazol; Coronary occlusion; Cyclic AMP; Epinephrine; Sarpogrelate

Indexed keywords

ADRENALIN; CILOSTAZOL; CYCLIC AMP; SARPOGRELATE; ANTIARRHYTHMIC AGENT; ANTITHROMBOCYTIC AGENT; SUCCINIC ACID DERIVATIVE; TETRAZOLE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROCARDIOGRAM; HEART INFARCTION; HEART VENTRICLE ARRHYTHMIA; INCIDENCE; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; RAT; ANIMAL; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEART VENTRICLE; METABOLISM; SPRAGUE DAWLEY RAT; TIME; UPREGULATION;

ANIMALIA; RATTUS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; CORONARY OCCLUSION; CYCLIC AMP; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; EPINEPHRINE; HEART VENTRICLES; MALE; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SUCCINATES; TETRAZOLES; TIME FACTORS; UP-REGULATION;

EID: 55449088781     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12012-008-9019-x     Document Type: Article

References (43)

1. EM Sorkin A Markham 1999 Cilostazol Drugs and Aging 14 63 71 10.2165/00002512-199914010-00005
2. M Igarashi T Okuda T Oh-i M Koga 2000 Changes in plasma serotonin concentration and acceleration plethysmograms in patients with Raynaud's phenomenon after long-term treatment with a 5-HT2 receptor antagonist Journal of Dermatology 27 643 650
3. E Tsuchikane A Fukuhara T Kobayashi M Kirino K Yamasaki T Kobayashi 1999 Impact of cilostazol on restenosis after percutaneous coronary balloon angioplasty Circulation 100 21 26
4. M Fujita K Mizuno M Ho R Tsukahara A Miyamoto O Miki 2003 Sarpogrelate treatment reduces restenosis after coronary stenting American Heart Journal 145 E16 10.1067/mhj.2003.176
5. SK Sharma DF Del Rizzo P Zahradka SK Bhangu JP Werner H Kumamoto 2007 Sarpogrelate inhibits serotonin-induced proliferation of porcine coronary artery smooth muscle cells: Implications for long-term graft potency Annals of Thoracic Surgery 7 1856 1865
6. HK Saini N Takeda RK Goyal H Kumamoto AS Arneja NS Dhalla 2004 Therapeutic potentials of sarpogrelate in cardiovascular disease Cardiovascular Drug Reviews 22 27 54
7. T Nagatomo M Rashid H Abul Muntasir T Komiyama 2004 Functions of 5-HT2A receptor and its antagonists in the cardiovascular system Pharmacology and Therapeutics 104 59 81 10.1016/j.pharmthera.2004.08.005
8. HK Saini SK Sharma P Zahradka H Kumamoto N Takeda NS Dhalla 2003 Alteration of serotin-induced increase in intracellular calcium in rat aortic smooth muscle cells by sarpogrelate Canadian Journal of Physiology and Pharmacology 81 1056 1063 10.1139/y03-108
9. G Fan YP Jiang Z Lu DW Martin DJ Kelly JM Zuckerman 2005 A transgenic mouse model of heart failure using inducible Galpha q Journal of Biological Chemistry 280 40337 40346 10.1074/jbc.M506810200
10. GJ Grover CA Sargent S Dzwonczyk DE Normandin MJ Antonaccio 1993 Protective effect of serotonin (5-HT2) receptor antagonists in ischemic rat hearts Journal of Cardiovascular Pharmacology 22 664 672 10.1097/00005344- 199310000-00022
11. XJ Du KE Anderson A Jacobsen EA Woodcock AM Dart 1995 Suppression of ventricular arrhythmias during ischemia-reperfusion by agents inhibiting Ins(1, 4, 5)P3 release Circulation 91 2712 2716
12. Y Shimizu S Minatoguchi K Hashimoto Y Uno M Arai N Wang 2002 The role of serotonin in ischemic cellular damage and the infarct size-reducing effect of sarpogrelate, a 5-hydroxytryptamine-2 receptor blocker, in rabbit hearts Journal of the American College of Cardiology 40 1347 1355 10.1016/S0735-1097(02)02158- 7
13. M Zehender T Meinertz S Hohnloser A Geibel J Hartung KU Seiler 1989 Incidence and clinical relevance of QT prolongation caused by the new selective serotonin antagonist ketanserin. Multicenter Ketanserin Research Group The American Journal of Cardiology 63 826 832 10.1016/0002-9149(89)90051-9
14. RM Temsah H Kumamoto N Takeda NS Dhalla 2001 Sarpogrelate diminishes changes in energy stores and ultrastructure of the ischemic-reperfused rat heart Canadian Journal of Physiology and Pharmacology 79 761 767 10.1139/cjpp-79-9- 761
15. D Brasil RM Temsah K Kumar H Kumamoto N Takeda NS Dhalla 2002 Blockade of 5-HT(2A) receptors by sarpogrelate protects the heart against myocardial infarction in rats Journal of Cardiovascular Pharmacology and Therapeutics 7 53 59 10.1177/107424840200700i108
16. M Packer JR Carver RJ Rodeheffer RJ Ivanhoe R DiBianco SM Zeldis 1991 Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group New England Journal of Medicine 325 1468 1475
17. JN Cohn SO Goldstein BH Greenberg BH Lorell RC Bourge BE Jaski 1998 A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators New England Journal of Medicine 339 1810 1816
18. Y Trolese-Mongheal J Barthelemy M Paire P Duchene-Marullaz 1992 Arrhythmogenic potencies of amrinone and milrinone in unanesthetized dogs with myocardial infarct General Pharmacology 23 95 104 10.1016/0306-3623(92)90054-N
19. S Wang J Cone M Fong M Yoshitake Ji Kambayashi Y Liu 2001 Interplay between inhibition of adenosine uptake and phosphodiesterase type 3 on cardiac function by cilostazol, an agent to treat intermittent claudication Journal of Cardiovascular Pharmacology 38 775 783 10.1097/00005344-200111000-00014
20. F Gamssari H Mahmood JS Ho RP Villareal B Liu A Rasekh 2002 Rapid ventricular tachycardias associated with cilostazol use Texas Heart Institute Journal 29 140 142
21. Sanganalmath, S. K., Babick, A. P., Barta, J., Kumamoto, H., Takeda, N., & Dhalla, N. S. (2007). Antiplatelet therapy attenuates subcellular remodeling in congestive heart failure. Journal of Cellular and Molecular Medicine. doi: 10.1111/j.1582-4934.2007.00197.
22. SK Sanganalmath J Barta H Kumamoto N Takeda NS Dhalla 2008 Antiplatelet therapy mitigates cardiac remodeling and dysfunction in congestive heart failure due to myocardial infarction Canadian Journal of Physiology and Pharmacology 86 180 189 10.1139/Y08-005
23. 2+-induced ventricular tachycardia in the intact pig heart Basic Research in Cardiology 75 772 779 10.1007/BF01910455
24. T Podzuweit DJ Els J McCarthy 1981 Cyclic AMP mediated arrhythmias induced in the ischemic pig heart Basic Research in Cardiology 78 443 448 10.1007/BF01908339
25. LA Kirshenbaum M Gupta TP Thomas PK Singal 1990 Antioxidant protection against adrenaline-induced arrhythmias in rats with chronic heart hypertrophy Canadian Journal of Cardiology 6 71 74
26. IM Dixon SL Lee NS Dhalla 1990 Nitrendipine binding in congestive heart failure due to myocardial infarction Circulation Research 66 782 788
27. MJ Walker MJ Curtis DJ Hearse RW Campbell MJ Janse DM Yellon 1998 The Lambeth conventions: Guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion Cardiovascular Research 22 447 455 10.1093/cvr/22.7.447
28. BP Damiano MR Rosen 1984 Effects of pacing on triggered activity induced by early afterdepolarizations Circulation 69 1013 1025
29. HJ Wellens P Brugada J Farre 1984 Ventricular arrhythmias: Mechanisms and actions of antiarrhythmic drugs American Heart Journal 107 1053 1057 10.1016/0002-8703(84)90174-1
30. BN Singh N Wadhani 2004 Antiarrhythmic and proarrhythmic properties of QT-prolonging antianginal drugs Journal of Cardiovascular Pharmacology and Therapeutics 9 S85 S97 10.1177/107424840400900107
31. RA Goldstein SA Geraci EL Gray RL Rinkenberger AH Dougherty GV Naccarelli 1986 Electrophysiologic effects of milrinone in patients with congestive heart failure American Journal of Cardiology 57 624 628 10.1016/0002-9149(86)90847-7
32. JJ Lynch Jr. AC Uprichard JW Frye EM Driscoll JM Kitzen BR Lucchesi 1989 Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction Journal of Cardiovascular Pharmacology 14 585 597 10.1097/00005344-198910000-00010
33. RW Piwonka JF Healey PC Canniff AE Farah 1983 Electrophysiological actions of amrinone in dogs with cardiac lesions Journal of Cardiovascular Pharmacology 5 1052 1057 10.1097/00005344-198311000-00021
34. AJ Kaumann L Sanders AM Brown KJ Murray MJ Brown 1990 A 5-hydroxytryptamine receptor in human right atrium British Journal of Pharmacology 100 879 885
35. 2A receptor antagonist sarpogrelate Latin American Archives of Cardiovascular Science 1 54 65
36. A Lukas GR Ferrier 1988 Electrophysiological effects of amrinone and milrinone in an isolated canine cardiac tissue model of ischemia and reperfusion Journal of Pharmacology and Experimental Therapeutics 244 348 354
37. M Packer N Medina M Yushak 1984 Failure of low doses of amrinone to produce sustained hemodynamic improvement in patients with severe chronic congestive heart failure American Journal of Cardiology 54 1025 1029 10.1016/S0002-9149(84)80138-1
38. PW Pflugfelder BJ O'Neill RI Ogilvie DS Beanlands PH Tanser H Tihal 1991 A Canadian multicentre study of a 48 h infusion of milrinone in patients with severe heart failure Canadian Journal of Cardiology 7 5 10
39. JW Cheng 1999 Cilostazol Heart Disease 1 182 186
40. K Schror 2002 The pharmacology of cilostazol Diabetes, Obesity and Metabolism 4 S14 S19 10.1046/j.1463-1326.2002.0040s2s14.x
41. Y Shakur M Fong J Hensley J Cone MA Movsesian J Kambayashi 2002 Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart Cardiovascular Drugs and Therapy 16 417 427 10.1023/A:1022186402442
42. A Van de Water R Xhonneux RS Reneman PA Janssen 1992 Cardiac and hemodynamic effects of intravenous R80122, a new phosphodiesterase III inhibitor, in a canine model of myocardial ischemia and heart failure Journal of Cardiovascular Pharmacology 20 18 24 10.1097/00005344-199207000-00004
43. 2+ current and developed tension in guinea-pig ventricular myocytes and papillary muscle: comparison with IBMX, milrinone, and cilostazol Cardiovascular Drugs and Therapy 13 105 113 10.1023/A:1007779908346