Olea europaea leaf extract exerts L-type Ca2+ channel antagonistic effects

Journal of Ethnopharmacology

Volumn 120, Issue 2, 2008, Pages 233-240

  Scheffler, A ^a   Rauwald, H W ^b   Kampa, B ^b   Mann, U ^b   Mohr, F W ^a   Dhein, S ^a  

^a UNIVERSITY OF LEIPZIG HEART CENTER   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Calcium antagonist; Epicardial mapping; L type calcium channel; Olea europaea; Oleuropein; Olive leaf extract; Voltage clamp

Indexed keywords

CALCIUM ANTAGONIST; CALCIUM CHANNEL L TYPE; OLEA EUROPAEA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; DRUG ISOLATION; EPICARDIUM MAPPING; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART RATE; ISOLATED HEART; MALE; NEWBORN; NONHUMAN; RABBIT; RAT; VOLTAGE CLAMP;

ANIMALS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EUROPE; FEMALE; HEART RATE; MALE; MEDICINE, TRADITIONAL; MYOCYTES, CARDIAC; OLEA; PATCH-CLAMP TECHNIQUES; PLANT EXTRACTS; PLANT LEAVES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY;

OLEA EUROPAEA; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 55349147657     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.08.018     Document Type: Article

References (34)

1. Alarcón de la Lastra C., Barranco M.D., Motilva V., and Herrerias J.M. Mediterranean diet and health: biological importance of olive oil. Current Pharmaceutical Design 7 (2001) 933-950
2. Arisi G., Macchi E., Baruffi S., Spaggiari S., and Taccardi B. Potential fields on the ventricular surface of the exposed dog heart during normal excitation. Circulation Research 52 (1983) 706-715
3. Dhein S., Rutten P., and Klaus W. A new method for analyzing the geometry and timecourse of epicardial potential spreading. International Journal of Biomedical Computing 23 (1988) 201-207
4. Dhein S., Müller A., and Klaus W. Prearrhythmia: changes preceeding arrhythmia, new aspects by epicardial mapping. Basic Research in Cardiology 85 (1990) 285-296
5. Dhein S., Müller A., Gerwin R., and Klaus W. Comparative study on the proarrhythmic effects of some antiarrhythmic agents. Circulation 87 (1993) 617-630
6. Durrer D., and van der Tweel L.H. Spread of activation in the left ventricular wall of the dog. II. Activation conditions at the epicardial surface. American Heart Journal 47 (1954) 192-203
7. Gariboldi P., Jommi G., and Verotta L. Secoiridoids from Olea europaea. Phytochemistry 25 (1986) 865-869
8. Gilani A.H., and Rahman A. Trends in ethnopharmacology. Journal of Ethnopharmacology 100 (2005) 43-49
9. Gilani A.H., Khan A., Shah A.J., Connor J., and Jabeen Q. Blood pressure lowering effect of olive is mediated through calcium channel blockade. International Journal of Food Sciences and Nutrition 56 (2005) 613-620
10. Gonzalez M., Zarzuelo A., Gamez M.J., Utrilla M.P., Jimenez J., and Osuna I. Hypoglycemic activity of olive leaf. Planta Medica 58 (1992) 513-515
11. Heimler D., Pieroni A., Tattini M., and Cimato A. Determination of flavonoids, flavonoid glycosides and biflavonoids in Olea europaea L. leaves. Chromatographia 33 (1992) 369-373
12. Hermann D.D. Naturoceutical agents in the management of cardiovascular diseases. American Journal of Cardiovascular Drugs 2 (2002) 173-196
13. Hoppe U.C., Brandt M.C., Michels G., and Lindner M. L-type calcium channel recording. In: Dhein S., Mohr F.W., and Delmar M. (Eds). Practical Methods in Cardiovascular Research (2005), Springer Verlag, Heidelberg 324-354
14. Kampa, B., 2006. Optimierung der HPLC von Ölbaumblättern (Ph. Eur.) und deren kommerziellen Zubereitungen unter Bestimmung verschiedenartiger phenolischer Verbindungen, Diplomarbeit, Lehrstuhl für Pharmazeutische Biologie, Universität Leipzig.
15. Keys A., Mienotti A., Karvonen M.J., Aravanis C., Blackburn H., Buzina R., Djordjevic B.S., Dontas A.S., Fidanza F., Keys M.H., Kromhout D., Nedeljkovic S., Punsar S., Seccareccia F., and Toshima H. The diet and 15-year death rate in the seven countries study. American Journal of Epidemiology 124 (1986) 903-915
16. Komaki E., Yamagughi S., Maru I., Kinoshita M., Kakehi K., Ohta Y., and Tsukada Y. Identification of anti-α-amylase components from olive leaf extracts. Food Science and Technology and Research 9 (2003) 35-39
17. Kosak R., and Stern P. Zur Wirkungsweise des hypotensiven Prinzips der Olivenblätter. Naunyn Schmiedebergs Arch Pharmacol 238 (1960) 117-119
18. Lasserre B., Kaiser R., Pham H.C., Ifansyah N., Gleye J., and Moulis C. Effect on rats of aqueous extracts of plants used in folk medicine as antihypertensive agents. Naturwissenschaften 70 (1983) 95-96
19. Le Tutour B., and Guedon D. Antioxidative activities of Olea europaea leaves and related phenolic compounds. Phytochemistry 31 (1992) 1173-1178
20. Millar C.K., Kralios F.A., and Lux R.L. Correlation between refractory periods and activation-recovery intervals from electrograms: effects of rate and adrenergic interventions. Circulation 72 (1985) 1372-1379
21. Müller A., Klaus W., and Dhein S. Heterogeneously distributed sensitivities to potassium as a cause of hypokalrmic arrhythmias in isolated rabbit hearts. Cardiovascular Electrophysiology 2 (1991) 145-155
22. Nattel S. Comparative mechanisms of action of antiarrhythmic drugs. American Journal of Cardiology 72 (1993) 13F-17F
23. Opie L.H. Calcium channel antagonists should be among the first-line drugs in the management of cardiovascular disease. Cardiovascular Drugs Therapy 10 (1996) 455-461
24. Petkov V., and Manolov P. Pharmacological analysis of the iridoid oleuropein. Arzneimittelforschung 22 (1972) 1476-1486
25. Pieroni A., Heimler D., Pieters L., van Poel B., and Vlietnick A.J. In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves. Pharmazie 51 (1996) 765-768
26. Rae J., Cooper K., Gates P., and Watsky M. Low access resistance perforated patch recordings using amphotericin B. Journal of Neuroscience Methods 37 (1991) 15-26
27. Rauwald H.W., Brehm O., and Odenthal K.P. Evaluation of the calcium antagonistic activity of Peucedanum ostruthium and Olea europaea constituents. Pharmacy and Pharmacological Letters 1 (1991) 78-81
28. Rauwald H.W., Brehm O., and Odenthal K.P. Screening of nine vasoactive medicinal plants for their possible calcium antagonistic activity. Strategy of selection and isolation for the active principles of Olea europaea and Peucedanum ostruthium. Phytotherapy Research 8 (1994) 135-140
29. Romani A., Baldi A., Tattini M., and Vincieri F.F. Extraction, purification procedures and HPLC-RI analysis of carbohydrates in olive (Olea europaea L.) plants. Chromatographia 39 (1994) 35-39
30. Silva S., Gomes L., Leitao F., Coelho A.V., and Boas L.V. Phenolic compounds and antioxidant activity of Olea europaea L. fruits and leaves. Food Science and Technology International 12 (2006) 385-395
31. Spach M.S., and Dolber P.C. Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age. Circulation Research 58 (1986) 356-371
32. Trichopoulou A., Kouris-Blazos A., Wahlqvist M.L., Gnardellis C., Lagiou P., Polychronopoulos E., Vassilakou T., Lipworth L., and Trichopoulos D. Diet and overall survival in elderly people. British Medical Journal 311 (1995) 1457-1460
33. World Health Organization, 2002. World Health Report 2002: Reducing Risks, Promoting Healthy Life. Geneva, Switzerland: World Health Organization; available at: http://www.who.int/whr/2002.
34. Zarzuelo A., Duarte J., Jimenez J., Gonzalez M., and Utrilla M.P. Vasodilator effect of olive leaf. Planta Medica 57 (1991) 417-419