Does gastroesophageal reflux have an influence on bleeding from esophageal varices?

Journal of Gastroenterology

Volumn 43, Issue 10, 2008, Pages 803-808

  Okamoto, Eisuke ^a   Amano, Yuji ^b   Fukuhara, Hiroyuki ^a   Furuta, Koichiro ^a   Miyake, Tatsuya ^b   Sato, Shuichi ^a   Ishihara, Shunji ^a   Kinoshita, Yoshikazu ^a  

^a SHIMANE UNIVERSITY   (Japan)

^b SHIMANE UNIVERSITY HOSPITAL   (Japan)

Author keywords

Bleeding; Esophageal varices; Gastroesophageal reflux; Red color sign

Indexed keywords

FAMOTIDINE; HISTAMINE H2 RECEPTOR ANTAGONIST; LANSOPRAZOLE; OMEPRAZOLE; PROTON PUMP INHIBITOR; RABEPRAZOLE;

ADULT; AGED; ARTICLE; COLOR; CONTROLLED STUDY; ERYTHROCYTE SHAPE; ESOPHAGUS HEMORRHAGE; ESOPHAGUS VARICES; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROSCOPY; HUMAN; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR;

AGED; COHORT STUDIES; ENDOSCOPY; ESOPHAGEAL AND GASTRIC VARICES; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PROTON PUMP INHIBITORS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 55349139308     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-008-2232-3     Document Type: Article

References (41)

1. Amitrano L, Guardascione MA, Bennato R, Manguso F, Balzano A. MELD score and hepatocellular carcinoma identify patients at different risk of short-term mortality among cirrhotics bleeding from esophageal varices. J Hepatol 2005;42:820-825.
2. Giannini EG, Risso D, Testa R, Trevisani F, Di Nolfo MA, Del Poggio P, et al.; Italian Liver Cancer (ITA.LI.CA.) Group. Prevalence and prognostic significance of the presence of esophageal varices in patients with hepatocellular carcinoma. Clin Gastroenterol Hepatol 2006;4:1378-1384.
3. Kovalak M, Lake J, Mattek N, Eisen G, Lieberman D, Zaman A. Endoscopic screening for varices in cirrhotic patients: Data from a national endoscopic database. Gastrointest Endosc 2007;65:82-88.
4. Pagliaro L, D'Amico G, Sorensen TI, Lebrec D, Burroughs AK, Morabito A, et al. Prevention of first bleeding in cirrhosis. A meta-analysis of randomized clinical trails of non-surgical treatment. Ann Intern Med 1992;117:59-70.
5. D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: A meta-analytic review. Hepatology 1995;22:332-354.
6. Sorbi D, Gostout CJ, Peura D, Johnson D, Lanza F, Foutch PG, et al. An assessment of the management of acute bleeding varices: A multicenter prospective member-based study. Am J Gastroenterol 2003;98:2424-2434.
7. Hori S, Takaki A, Okada H, Fujiwara A, Takenaka R, Makidono C, et al. Endoscopic therapy for bleeding esophageal varices improves the outcome of Child C cirrhotic patients. J Gastroenterol Hepatol 2006;21:1704-1709.
8. Jensen DM. Endoscopic screening for varices in cirrhosis: Findings, implications, and outcomes. Gastroenterology 2002;122:1620-1630.
9. Merli M, Nicolini G, Angeloni S, Rinaldi V, De Santis A, Merkel C, et al. Incidence and natural history of small esophageal varices in cirrhotic patients. J Hepatol 2003;38:266-272.
10. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-649.
11. Merkel C, Zoli M, Siringo S, van Buuren H, Magalotti D, Angeli P, et al. Prognostic indicators of risk for first variceal bleeding in cirrhosis: a multicenter study in 711 patients to validate and improve the North Italian Endoscopic Club (NIEC) index. Am J Gastroenterol 2000;95:2915-2920.
12. Zoli M, Merkel C, Magalotti D, Gueli C, Grimaldi M, Gatta A, et al. Natural history of cirrhotic patients with small esophageal varices: A prospective study. Am J Gastroenterol 2000;95:503-508.
13. Nevens F, Bustami R, Scheys I, Lesaffre E, Fevery J. Variceal pressure is a factor predicting the risk of a first variceal bleeding: A prospective cohort study in cirrhotic patients. Hepatology 1998;27:15-19.
14. El Atti EA, Nevens F, Bogaerts K, Verbeke G, Fevery J. Variceal pressure is a strong predictor of variceal hemorrhage in patients with non-cirrhotic portal hypertension. Gut 1999;45:618-621.
15. Merkel C, Bolognesi M, Sacerdoti D, Bombonato G, Bellini B, Bighin R, et al. The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2000;32:930-934.
16. Faigel DO, Rosen HR, Sasaki A, Flora K, Benner K. EUS in cirrhotic patients with and without prior variceal hemorrhage in comparison with noncirrhotic control subjects. Gastrointest Endosc 2000;52:575-577.
17. Chiu KC, Sheu BS, Chuang CH. Portal venous flow pattern as a useful tool for predicting esophageal varix bleeding in cirrhotic patients. Dig Dis Sci 2005;50:1170-1174.
18. Japanese Research Society for Portal Hypertension. The general rules for recording endoscopic findings on esophageal varices. Jpn J Surg 1980;10:84-87.
19. Idezuki Y, Japanese Research Society for Portal Hypertension. General rules for recording endoscopic findings of esophagogastric varices (1991). World J Surg 1995;19:420-423.
20. Beppu K, Inokuchi K, Koyanagi N, Nakayama S, Sakata H, Kitano S, et al. Prediction of variceal hemorrhage by esophageal endoscopy. Gastrointest Endosc 1981;27:231-238.
21. The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. N Engl J Med 1988;319:983-989.
22. Kleber G, Sauerbruch T, Ansari H, Paumgartner G. Prediction of variceal hemorrhage in cirrhosis: A prospective follow-up study. Gastroenterology 1991;100:1332-1337.
23. Katsube T, Adachi K, Furuta K, Miki M, Fujisawa T, Azumi T, et al. Difference in location of esophageal mucosal breaks among grades of esophagitis. J Gastroenterol Hepatol 2006;21:1656-1659.
24. Siringo S, McCormick PA, Mistry P, Kaye G, McIntyre N, Burroughs AK. Prognostic significance of the white nipple sign in variceal bleeding. Gastrointest Endosc 1991;37:51-55.
25. Hou MC, Lin HC, Kuo BI, Lee FY, Schmidt CM, Lee SD. Clinical implications of the white nipple sign and its role in the diagnosis of esophageal variceal hemorrhage. Am J Gastroenterol 1996;91:2103-2109.
26. Goh SH, Tan WP, Lee SW. Clinical predictors of bleeding esophageal varices in the ED. Am J Emerg Med 2005;23:531-535.
27. Toyonaga A, Oho K. Clinical implications of the red color sign on esophageal varices. J Gastroenterol 2001;36:433-435.
28. Miyoshi H, Matsumoto A, Oka M, Sugi K, Yoshimura K, Hongou Y, et al. Efficacy of prophylactic sclerotherapy in patients with hepatocellular carcinoma and varices negative for the red color sign. Gastrointest Endosc 1997;45:498-502.
29. Ito K, Matsutani S, Maruyama H, Akiike T, Nomoto H, Suzuki T, et al. Study of hemodynamic changes in portal systemic shunts and their relation to variceal relapse after endoscopic variceal ligation combined with ethanol sclerotherapy. J Gastroenterol 2006;41:119-126.
30. Li FH, Hao J, Xia JG, Li HL, Fang H. Hemodynamic analysis of esophageal varices in patients with liver cirrhosis using color Doppler ultrasound. World J Gastroenterol 2005;11:4560-4565.
31. Hino S, Kakutani H, Ikeda K, Uchiyama Y, Sumiyama K, Kuramochi A, et al. Hemodynamic assessment of the left gastric vein in patients with esophageal varices with color Doppler EUS: Factors affecting development of esophageal varices. Gastrointest Endosc 2002;55:512-517.
32. Kakutani H, Hino S, Ikeda K, Sumiyama K, Uchiyama Y, Kuramochi A, et al. Prediction of recurrence of esophageal varices: Special reference to a role for endoscopic ultrasonography. Hepatol Res 2005;33:259-266.
33. Chen SM, Lo GH, Lai KH, Jeng JS, Shen MT, Huang RL, et al. Influence of endoscopic variceal ligation on oesophageal motility. J Gastroenterol Hepatol 1999;14:231-235.
34. Passaretti S, Mazzotti G, de Franchis R, Cipolla M, Testoni PA, Tittobello A. Esophageal motility in cirrhotics with and without esophageal varices. Scand J Gastroenterol 1989;24:334-338.
35. Iwakiri K, Kobayashi M, Sesoko M, Nomura T. Gastroesophageal reflux and esophageal motility in patients with esophageal varices. Gastroenterol Jpn 1993;28:477-482.
36. Ahmed AM, al Karawi MA, Shariq S, Mohamed AE. Frequency of gastroesophageal reflux in patients with liver cirrhosis. Hepatogastroenterology 1993;40:478-480.
37. Komazawa Y, Adachi K, Mihara T, Ono M, Kawamura A, Fujishiro H, et al. Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection. J Gastroenterol Hepatol 2003;18:678-682.
38. Furuta K, Adachi K, Komazawa Y, Mihara T, Miki M, Azumi T, et al. Tolerance to H2 receptor antagonist correlates well with the decline in efficacy against gastroesophageal reflux in patients with gastroesophageal reflux disease. J Gastroenterol Hepatol 2006;21:1581-1585.
39. Sluss KF, Donahue PE, Rypins EB, Liu KJ, Richter HM, Miidla IH, et al. Marked asymmetry of LES: Important element of LES barrier in subsets of patients with reflux symptoms. Am Surg 1995;61:573-580.
40. Orloff MJ, Thomas HS. Pathogenesis of esophageal varix rupture. A study based on gross and microscopic examination of the esophagus at the time of bleeding. Arch Surg 1963;87:301-307.
41. Ponce J, Froufe A, de la Morena E, Mir J, Rayón M, Pina R, et al. Morphometric study of the esophageal mucosa in cirrhotic patients with variceal bleeding. Hepatology 1981;1:641-646.