Chemically induced accumulation of GAGs delays PrPSc clearance but prolongs prion disease incubation time

Cellular and Molecular Neurobiology

Volumn 28, Issue 7, 2008, Pages 1005-1015

  Mayer Sonnenfeld, Tehila ^a   Avrahami, Dana ^a   Friedman Levi, Yael ^a   Gabizon, Ruth ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Creutzfeldt Jakob disease; PrP; Spongiform encephalopathy; Tilorone

Indexed keywords

PRION PROTEIN; TILORONE;

ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; IN VIVO STUDY; INCUBATION TIME; INFECTION; LYSOSOME; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; ANTIVIRAL AGENTS; CENTRAL NERVOUS SYSTEM; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME INHIBITORS; GLYCOSAMINOGLYCANS; INFECTIOUS DISEASE INCUBATION PERIOD; LYSOSOMES; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED C57BL; NEURONS; PRION DISEASES; PROTEIN CONFORMATION; PRPSC PROTEINS; QUINACRINE; SUBCELLULAR FRACTIONS; TILORONE; TIME FACTORS;

ANIMALIA; MUS;

EID: 55349133045     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-008-9274-1     Document Type: Article

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