Interaction effects and subgroup analyses in clinical trials: More than meets the eye?

Journal of Evaluation in Clinical Practice

Volumn 14, Issue 5, 2008, Pages 919-922

  Sevdalis, Nick ^a,b,c   Jacklin, Rosamond ^d  

^a ST MARY S HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c NATIONAL PATIENT SAFETY AGENCY   (United Kingdom)

^d NONE

Author keywords

General linear model; Interaction effects; Subgroup analyses

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; PLACEBO;

ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CLINICAL RESEARCH; DRUG EFFICACY; HUMAN; MEDICAL LITERATURE; PRIORITY JOURNAL; SHORT SURVEY; THROMBOSIS;

ASPIRIN; BIAS (EPIDEMIOLOGY); CAUSALITY; CLINICAL TRIALS AS TOPIC; CONFOUNDING FACTORS (EPIDEMIOLOGY); DATA INTERPRETATION, STATISTICAL; EFFECT MODIFIERS (EPIDEMIOLOGY); FACTOR ANALYSIS, STATISTICAL; HUMANS; INCIDENCE; LINEAR MODELS; PLATELET AGGREGATION INHIBITORS; PROBABILITY; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; RISK FACTORS; THROMBOSIS; TICLOPIDINE; TREATMENT OUTCOME;

EID: 55349127538     PISSN: 13561294     EISSN: 13652753     Source Type: Journal    
DOI: 10.1111/j.1365-2753.2007.00872.x     Document Type: Short Survey

References (10)

1. Morton, V. Torgerson, D. J. (2005) Regression to the mean: treatment effect without the intervention. Journal of Evaluation in Clinical Practice, 11, 59 65.
2. Assmann, S. F., Pocock, S. J., Enos, L. E. Kasten, E. L. (2000) Subgroup analyses and other (mis)uses of baseline data in clinical trials. Lancet, 355, 1064 1069.
3. Lagakos, S. W. (2006) The challenge of subgroup analyses - reporting without distorting. New England Journal of Medicine, 354, 1667 1669.
4. Schultz, K. F. Grimes, D. A. (2005) Multiplicity in randomised trials II: subgroup and interim analyses. Lancet, 365, 1591 1595.
5. Yusuf, S., Wittes, J., Probstfield, J. Tyroler, H. A. (1991) Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials. Journal of the American Medical Association, 266, 93 98.
6. Bhatt, D. L., Fox, K. A. A., Hacke, W., et al. (2006) Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. New England Journal of Medicine, 354, 1706 1717.
7. Howell, D. C. (1997) Statistical Methods for Psychology, 4th Edn. Belmont, CA : Duxbury Press.
8. Toothaker, L. E. (1991) Multiple Comparisons for Researchers. Newbury Park, CA : Sage.
9. Rothwell, P. M. (2005) Subgroup analysis in randomised controlled trials: importance, indications, and interpretation. Lancet, 365, 176 186.
10. McCullagh, P. Nelder, J. A. (1989) Generalized Linear Models, 2nd Edn. London : Chapman & Hall/CRC.