Strongly increased international normalized ratio with recombinant neoplastin R® compared with tissue extract neoplastin plus® in patients initiating oral anticoagulant therapy: Implications for anticoagulation dosage

Clinical Chemistry

Volumn 54, Issue 11, 2008, Pages 1929-1931

  Remijn, Jasper A ^a,b   Lucas, Sam ^a   Wildeboer, Bertil ^a   Van Suijlen, Jeroen D E ^a   Adriaansen, Henk J ^a  

^a Gelre Ziekenhuizen ^*  (Netherlands)

^b GELRE HOSPITALS   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACENOCOUMAROL; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; NEOPLASTIN PLUS; NEOPLASTIN R; PROTHROMBIN; RECOMBINANT THROMBOPLASTIN; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANTICOAGULANT THERAPY; DOSE CALCULATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; LETTER; LINEAR REGRESSION ANALYSIS; LOADING DRUG DOSE; PLASMA HALF LIFE; PROTHROMBIN TIME;

ADMINISTRATION, ORAL; ANTICOAGULANTS; HUMANS; INDICATORS AND REAGENTS; INTERNATIONAL NORMALIZED RATIO; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY;

EID: 55349122906     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2008.111336     Document Type: Letter

References (5)

1. WHO Expert Committee on Biological Standardization. Guidelines for thromboplastins and plasma used to control oral anticoagulant therapy. WHO Tech Rep Series 1999;889: 64-93.
2. Bader R, Mannucci PM, Tripodi A, Hirsh J, Keller F, Solleder EM, et al. Multicenter evaluation of a new PT reagent based on recombinant human tissue factor and synthetic phospholipids. Thromb Haemost 1994;71:292-9.
3. Testa S, Morstabilini G, Fattorini A, Galli L, Denti N, D'Angelo A. Discrepant sensitivity of thromboplastin reagents to clotting factor levels explored by the prothrombin time in patients on stable oral anticoagulant treatment: impact on the international normalized ratio system. Haematologica 2002;87:1265-73.
4. Weinstock DM, Chang P, Aronson DL, Kessler CM. Comparison of plasma prothrombin and factor VII and urine prothrombin F1 concentrations in patients on long-term warfarin therapy and those in the initial phase. Am J Hematol 1998;57:193-9.
5. Johnston M, Harrison L, Moffat K, Willan A, Hirsh J. Reliability of the international normalized ratio for monitoring the induction phase of warfarin: comparison with the prothrombin time ratio. J Lab Clin Med 1996 128:214-7.