Does the effectiveness of the ketogenic diet in different epilepsies yield insights into its mechanisms?

Epilepsia

Volumn 49, Issue SUPPL. 8, 2008, Pages 53-56

  Hartman, Adam L ^a   Freeman, John M ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

AMP activated kinase; Dravet syndrome; Ketogenic diet; Lennox Gastaut syndrome; Rett syndrome; Tuberous sclerosis

Indexed keywords

GLUCOSE TRANSPORTER 1;

CONFERENCE PAPER; DEGENERATIVE DISEASE; DIET THERAPY; EPILEPSY; GENE MUTATION; GENETIC DISORDER; HUMAN; KETOGENIC DIET; LENNOX GASTAUT SYNDROME; MYOCLONUS EPILEPSY; MYOCLONUS SEIZURE; NONHUMAN; PRIORITY JOURNAL; RETT SYNDROME; TUBEROUS SCLEROSIS;

ANIMALS; EPILEPSY; HUMANS; KETOGENIC DIET;

EID: 55349122235     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01835.x     Document Type: Conference Paper

References (35)

1. Appleton DB, DeVivo DC 1974) An animal model for the ketogenic diet. Epilepsia 15 : 211 227.
2. Bergqvist AG, Chee CM, Lutchka LM, Brooks-Kayal AR 1999) Treatment of acquired epileptic aphasia with the ketogenic diet. J Child Neurol 14 : 696 701.
3. Bough KJ, Wetherington J, Hassel B, Pare JF, Gawryluk JW, Greene JG, Shaw R, Smith Y, Geiger JD, Dingledine RJ 2006) Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann Neurol 60 : 223 235.
4. Caraballo RH, Cersósimo RO, Sakr D, Cresta A, Escobal N, Fejerman N 2005) Ketogenic diet in patients with Dravet syndrome. Epilepsia 46 : 1539 1544.
5. Cardinali S, Canafoglia L, Bertoli S, Franceschetti S, Lanzi G, Tagliabue A, Veggiotti P 2006) A pilot study of a ketogenic diet in patients with Lafora body disease. Epilepsy Res 69 : 129 134.
6. Dutton SBB, Escayg A. (2008) Genetic influences on ketogenic diet efficacy. Epilepsia 49 (Suppl. 8 67 69.
7. Freeman JM, Vining EP, Pillas DJ, Pyzik PL, Casey JC, Kelly LM 1998) The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 102 : 1358 1363.
8. Freeman JM, Vining EP 1999) Seizures decrease rapidly after fasting: preliminary studies of the ketogenic diet. Arch Pediatr Adolesc Med 153 : 946 949.
9. Haas RH, Rice MA, Trauner DA, Merritt TA 1986) Therapeutic effects of a ketogenic diet in Rett syndrome. Am J Med Genet Suppl 1 : 225 246.
10. Hartman AL, Gasior M, Vining EPG, Rogawski MA. (2007) The neuropharmacology of the ketogenic diet. Pediatric Neurology 36 : 281 292.
11. Helbig I, Scheffer IE, Mulley JC, Berkovic SF 2008) Navigating the channels and beyond: unraveling the genetics of the epilepsies. Lancet Neurol 7 : 231 245.
12. Henderson CB, Filloux FM, Alder SC, Lyon JL, Caplin DA 2006) Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis. J Child Neurol 21 : 193 198.
13. Huttenlocher PR. (1976) Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res 10 : 536 540.
14. Inoki K, Zhu T, Guan KL 2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115 : 577 590.
15. Kang HC, Kim YJ, Kim DW, Kim HD 2005) Efficacy and safety of the ketogenic diet for intractable childhood epilepsy: Korean multicentric experience. Epilepsia 46 : 272 279.
16. Kossoff EH, Thiele EA, Pfeifer HH, McGrogan JR, Freeman JM 2005) Tuberous sclerosis complex and the ketogenic diet. Epilepsia 46 : 1684 1686.
17. Lefevre F, Aronson N 2000) Ketogenic diet for the treatment of refractory epilepsy in children: a systematic review of efficacy. Pediatrics 105 : E46.
18. Lux AL, Edwards SW, Hancock E, Johnson AL, Kennedy CR, Newton RW, O'Callaghan FJ, Verity CM, Osborne JP 2004) The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial. Lancet 364 : 1773 1778.
19. Mackay MT, Weiss SK, Adams-Webber T, Ashwal S, Stephens D, Ballaban-Gill K, Baram TZ, Duchowny M, Hirtz D, Pellock JM, Shields WD, Shinnar S, Wyllie E, Snead OC 3rd. American Academy of Neurology; Child Neurology Society 2004) Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. Neurology 62 : 1668 1681.
20. Martinez CC, Pyzik PL, Kossoff EH 2007) Discontinuing the ketogenic diet in seizure-free children: recurrence and risk factors. Epilepsia 48 : 187 190.
21. Maydell BV, Wyllie E, Akhtar N, Kotagal P, Powaski K, Cook K, Weinstock A, Rothner AD 2001) Efficacy of the ketogenic diet in focal versus generalized seizures. Pediatr Neurol 25 : 208 212.
22. Oguni H, Tanaka T, Hayashi K, Funatsuka M, Sakauchi M, Shirakawa S, Osawa M 2002) Treatment and long-term prognosis of myoclonic-astatic epilepsy of early childhood. Neuropediatrics 33 : 122 132.
23. Reger MA, Henderson ST, Hale C, Cholerton B, Baker LD, Watson GS, Hyde K, Chapman D, Craft S 2004) Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging 25 : 311 314.
24. Rogawski MA, Reddy DS 2002) Neurosteroids and infantile spasms: the deoxycorticosterone hypothesis. Int Rev Neurobiol 49 : 199 219.
25. Ross DL, Swaiman KF, Torres F, Hansen J 1985) Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy. Pediatr Neurol 1 : 104 108.
26. Sankar R, Wheless JW, Dravet C, Guerrini R, Medina MT, Bureau M, Genton P, Delgado-Escueta AV 2005) Treatment of myoclonic epilepsies in infancy and early childhood. Adv Neurol 95 : 289 298.
27. Saywell V, Viola A, Confort-Gouny S, Le Fur Y, Villard L, Cozzone PJ 2006) Brain magnetic resonance study of Mecp2 deletion effects on anatomy and metabolism. Biochem Biophys Res Commun 340 : 776 783.
28. Scheffer IE, Wallace R, Mulley JC, Berkovic SF 2001) Clinical and molecular genetics of myoclonic-astatic epilepsy and severe myoclonic epilepsy in infancy (Dravet syndrome). Brain Dev 23 : 732 735.
29. Schwartz RH, Eaton J, Bower BD, Aynsley-Green A 1989) Ketogenic diets in the treatment of epilepsy: short-term clinical effects. Dev Med Child Neurol 31 : 145 151.
30. Seyfried TN, Kiebish M, Mukherjee P, Marsh J. (2008) Targetking energy metabolism in brain cancer with calorically restricted ketogenic diets. Epilepsia 49 (Suppl. 8 113 115.
31. Than KD, Kossoff EH, Rubenstein JE, Pyzik PL, McGrogan JR, Vining EP 2005) Can you predict an immediate, complete, and sustained response to the ketogenic diet? Epilepsia 46 : 580 582.
32. Thio LL, Wong M, Yamada KA 2000) Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission. Neurology 54 : 325 331.
33. Velísek L, Jehle K, Asche S, Velísková J 2007) Model of infantile spasms induced by N-methyl-D-aspartic acid in prenatally impaired brain. Ann Neurol 61 : 109 119.
34. Wheless JW, Clarke DF, Carpenter D 2005) Treatment of pediatric epilepsy: expert opinion, 2005. J Child Neurol 20 (Suppl 1 S1 S56.
35. Zeng LH, Xu L, Gutmann DH, Wong M 2008) Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol 63 : 444 453.