Merkel cell carcinoma within follicular cysts: Report of two cases

Journal of Cutaneous Pathology

Volumn 35, Issue 12, 2008, Pages 1127-1133

  Requena, Luis ^a,c   Jaqueti, Gerardo ^a   Rütten, Arno ^b   Mentzel, Thomas ^b   Kutzner, Heinz ^b  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b Dermatopathologische Gemeinschaftspraxis   (Germany)

^c Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOGRANIN; CYTOKERATIN 20; KERATIN; NEURON SPECIFIC ENOLASE; PROTEIN CAM 5.2; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

AGED; ARTICLE; CASE REPORT; FOLLICLE CYST; GANGLION CYST; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MERKEL CELL TUMOR; PROTEIN EXPRESSION;

AGED; CARCINOMA, MERKEL CELL; FOLLICULAR CYST; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; SKIN NEOPLASMS;

EID: 55349116092     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/j.1600-0560.2007.00919.x     Document Type: Article

References (24)

1. Sibley RK, Dehner LP, Rosai J. Primary neuroendocrine (Merkel cell?) carcinoma of the skin. I. A clinicopathologic and ultrastructural study of 43 cases. Am J Surg Pathol 1985 9 : 95.
2. Kroll MH, Toker C. Trabecular carcinoma of the skin. Arch Pathol Lab Med 1982 106 : 404.
3. LeBoit PE, Crutcher WA, Shapiro PE. Pagetoid intraepidermal spread in Merkel cell (primary neuroendocrine) carcinoma of the skin. Am J Surg Pathol 1992 16 : 584.
4. Tang C-K, Nedwich A, Toker C, Zaman ANF. Unusual cutaneous carcinoma with features of small cell (oat-cell like) and squamous cell carcinoma. Am J Dermatopathol 1982 4 : 537.
5. Gomez LG, Silva EG, DiMaio S, Mackay B. Association between neuroendocrine (Merkel cell) carcinoma and squamous carcinoma of the skin. Am J Surg Pathol 1983 7 : 171.
6. Iacocca MV, Abernethy JL, Stefanato CM, Allan AE, Bhawan J. Mixed Merkel cell carcinoma and squamous cell carcinoma of the skin. J Am Acad Dermatol 1988 39 : 882.
7. Heenan PJ, Cole JM, Spagnolo DV. Primary cutaneous neuroendocrine carcinoma (Merkel cell tumor). Am J Dermatopathol 1990 12 : 7.
8. Yamamoto O, Tanimoto A, Yasuda H, et al. A combined occurrence of neuroendocrine carcinoma of the skin and a benign appendageal neoplasm. J Cutan Pathol 1993 20 : 173.
9. Perse RM, Klappenbach RS, Ragsdale BD. Trabecular (Merkel cell) carcinoma arising in the wall of an epidermal cyst. Am J Dermatopathol 1987 9 : 423.
10. Collina G, Bagni A, Fano RA. Combined neuroendocrine carcinoma of the skin (Merkel cell tumor) and trichilemmal cyst. Am J Dermatopathol 1997 19 : 545.
11. Ivan D, Bengana C, Lazar AJ, Diwan AH, Prieto VG. Merkel cell tumor in a trichilemmal cyst: collision or association. Am J Dermatopathol 2007 29 : 180.
12. Moll I, Roeslsler M, Brandner JM, et al. Human Merkel cells - aspects of cell biology, distribution and functions. Eur J Cell Biol 2005 84 : 259.
13. Narisawa Y, Hashimoto K, Kohda H. Epithelial skirt and bulge of human facial vellus hair follicles and associated Merkel cell-nerve complex. Arch Dermatol Res 1993 285 : 269.
14. Narisawa Y, Hashimoto K, Nakamura Y, et al. A high concentration of Merkel cell in the bulge prior to the attachment of the arrector pili muscle and the formation of the perifollicular nerve plexus in human fetal skin. Arch Dermatol Res 1993 285 : 261.
15. Narisawa Y, Kohda H. Two- and three-dimensional demonstration of morphological alterations of early anagen hair follicle with special reference to the bulge area. Arch Dermatol Res 1996 288 : 98.
16. Moll I. Merkel cell distribution in human hair follicles of the fetal and adult scalp. Cell Tissue Res 1994 227 : 131.
17. Abesamis-Cubillan E, El-Shabrawi-Caelen L, LeBoit PE. Merkel cells and sclerosing epithelial neoplasms. Am J Dermatopathol 2000 22 : 311.
18. Gould VE, Moll R, Moll I, et al. Biology of disease: neuroendocrine (Merkel) cells of the skin: hyperplasias, dysplasias, and neoplasms. Lab Invest 1985 52 : 334.
19. Hartschuh W, Schulz T. Merkel cells are integral constituents of desmoplastic trichoepithelioma: an immunohistochemical and electron microscopic study. J Cutan Pathol 1995 22 : 413.
20. Schulz T, Hartschuh W. Merkel cells in nevus sebaceus. Am J Dermatopathol 1995 17 : 570.
21. Cotsarelis G, Sun T-T, Lavker RM. Label-retaining cells reside in the bulge area of the pilosebaceous unit: implications for follicular stem cells, hair cycle and skin carcinogenesis. Cell 1990 61 : 1329.
22. Schultz T, Hartschuh W. Merkel cells are absent in basal cell carcinomas but frequently found in trichoblastomas: an immunohistochemical study. J Cutan Pathol 1997 24 : 477.
23. Hartschuh W, Schultz T. Immunohistochemical investigation of the different developmental stages of trichofolliculoma with special reference to the Merkel cells. Am J Dermatopathol 1999 21 : 8.
24. Hartschuh W, Schultz T. Merkel cell hyperplasia in chronic radiation-damaged skin: its possible relationship to fibroepithelioma of Pinkus. J Cutan Pathol 1997 24 : 477.