Effects of in utero exposure to 2,2′,4,4′,5,5′- hexachlorobiphenyl (PCB 153) on somatic growth and endocrine status in rat offspring

Congenital Anomalies

Volumn 48, Issue 4, 2008, Pages 151-157

  Kobayashi, Kenichi ^a   Miyagawa, Muneyuki ^a   Wang, Rui Sheng ^a   Suda, Megumi ^a   Sekiguchi, Soichiro ^a   Honma, Takeshi ^a  

^a NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH   (Japan)

Author keywords

2,2 ,4,4 ,5,5 hexachlorobiphenyl (PCB 153); Somatic growth; Thyroid stimulating hormone; Thyroxine; Tri iodothyronine

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; LIOTHYRONINE; SOMATOMEDIN C; THYROTROPIN; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY GROWTH; BODY HEIGHT; BODY WEIGHT; CONTROLLED STUDY; ENDOCRINE FUNCTION; FEMALE; GROWTH HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HYPOPHYSIS THYROID SYSTEM; KIDNEY MASS; LIOTHYRONINE BLOOD LEVEL; LIVER WEIGHT; MALE; NONHUMAN; ORGAN GROWTH; POSTNATAL DEVELOPMENT; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; RAT; TESTIS WEIGHT; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; UTERUS WEIGHT;

ANIMALS; ANIMALS, NEWBORN; FEMALE; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; MALE; ORGAN SIZE; POLYCHLORINATED BIPHENYLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

RATTUS;

EID: 55349115766     PISSN: 09143505     EISSN: 17414520     Source Type: Journal    
DOI: 10.1111/j.1741-4520.2008.00199.x     Document Type: Article

References (29)

1. Axmon A, Rylander L, Stromberg U, Dyremark E, Hagmar L (2001) Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in relation to time to pregnancy. J Toxicol Environ Health A 64 : 485 498.
2. Bowers WJ, Nakai JS, Chu I et al 2004) Early developmental neurotoxicity of a PCB/organochlorine mixture in rodents after gestational and lactational exposure. Toxicol Sci 77 : 51 62.
3. Cheek AO, Kow K, Chen J, McLachlan JA (1999) Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ Health Perspect 107 : 273 278.
4. Chu I, Villeneuve DC, Yagminas A et al 1996) Toxicity of 2,2′,4,4′,5,5′-hexachlorobiphenyl in rats: effects following 90-day oral exposure. J Appl Toxicol 16 : 121 128.
5. Connor K, Safe S, Jefcoate CR, Larsen M (1995) Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats. Biochem Pharmacol 50 : 1913 1920.
6. Gallavan RH Jr., Holson JF, Stump DG, Knapp JF, Reynolds VL (1999) Interpreting the toxicologic significance of alterations in anogenital distance: Potential for confounding effects of progeny body weights. Reprod Toxicol 13 : 383 390.
7. Gauger KJ, Kato Y, Haraguchi K et al 2004) Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors. Environ Health Perspect 112 : 516 523.
8. Goldey ES, Kehn LS, Lau C, Rehnberg GL, Crofton KM (1995) Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. Toxicol Appl Pharmacol 135 : 77 88.
9. Kitamura S, Jinno N, Suzuki T et al 2005) Thyroid hormone-like and estrogenic activity of hydroxylated PCBs in cell culture. Toxicology 208 : 377 387.
10. Koibuchi N, Chin WW (2000) Thyroid hormone action and brain development. Trends Endocrinol Metab 11 : 123 128.
11. Koopman-Esseboom C, Morse DC, Weisglas-Kuperus N et al 1994) Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr Res 36 : 468 473.
12. Küchenhoff A, Eckard R, Buff K, Fischer B (1999) Stage-specific effects of defined mixtures of polychlorinated biphenyls on in vitro development of rabbit preimplantation embryos. Mol Reprod Dev 54 : 126 134.
13. McKinney JD, Waller CL (1994) Polychlorinated biphenyls as hormonally active structural analogues. Environ Health Perspect 102 : 290 297.
14. Morse DC, Groen D, Veerman M et al 1993) Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats. Toxicol Appl Pharmacol 122 : 27 33.
15. National Toxicology Program (2006) NTP technical report on the toxicology and carcinogenesis studies of 2,2′,4,4′,5,5′- hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (Gavage studies). Natl Toxicol Program Tech Rep Ser 529 : 4 168.
16. Ness DK, Schantz SL, Moshtaghian J, Hansen LG (1993) Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat. Toxicol Lett 68 : 311 323.
17. Ohlsson C, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC (1998) Growth hormone and bone. Endocr Rev 19 : 55 79.
18. Oppenheimer JH, Schwartz HL (1997) Molecular basis of thyroid hormone-dependent brain development. Endocr Rev 18 : 462 475.
19. Oskam IC, Lyche JL, Krogenaes A et al 2005) Effects of long-term maternal exposure to low doses of PCB126 and PCB153 on the reproductive system and related hormones of young male goats. Reproduction 130 : 731 742.
20. Porterfield SP, Hendrich CE (1993) The role of thyroid hormones in prenatal and neonatal neurological development - current perspectives. Endocr Rev 14 : 94 106.
21. Safe SH (1994) Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 24 : 87 149.
22. Sauer PJ, Huisman M, Koopman-Esseboom C et al 1994) Effects of polychlorinated biphenyls (PCBs) and dioxins on growth and development. Hum Exp Toxicol 13 : 900 906.
23. Schantz SL, Moshtaghian J, Ness DK (1995) Spatial learning deficits in adult rats exposed to ortho-substituted PCB congeners during gestation and lactation. Fundam Appl Toxicol 26 : 117 126.
24. Seo BW, Li MH, Hansen LG, Moore RW, Peterson RE, Schantz SL (1995) Effects of gestational and lactational exposure to coplanar polychlorinated biphenyl (PCB) congeners or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thyroid hormone concentrations in weanling rats. Toxicol Lett 78 : 253 262.
25. Sharlin DS, Tighe D, Gilbert ME, Zoeller RT (2008) The balance between oligodendrocyte and astrocyte production in major white matter tracts is linearly related to serum total thyroxine. Endocrinology 149 : 2527 2536.
26. Tanabe S (1988) PCB problems in the future: Foresight from current knowledge. Environ Pollut 50 : 5 28.
27. Vezina CM, Walker NJ, Olson JR (2004) Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: Effect on hepatic gene expression. Environ Health Perspect 112 : 1636 1644.
28. Whitlock JP Jr. 1999) Induction of cytochrome P4501A1. Annu Rev Pharmacol Toxicol 39 : 103 125.
29. Zoeller RT, Dowling AL, Vas AA (2000) Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain. Endocrinology 141 : 181 189.