A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 147, Issue 7, 2008, Pages 1301-1305

  Ghosh, Saurabh ^a,b   Bierut, Laura J ^b   Porjesz, Bernice ^c   Edenberg, Howard J ^d   Dick, Danielle ^b   Goate, Alison ^b   Hesselbrock, Victor ^e   Nurnberger Jr , John ^d   Foroud, Tatiana ^d   Kramer, John ^f   Rice, John ^b   Begleiter, Henri ^c  

^a INDIAN STATISTICAL INSTITUTE   (India)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF IOWA   (United States)

Author keywords

Externalizing symptoms; Linkage; Non parametric regression

Indexed keywords

ALCOHOL DEHYDROGENASE;

ADOLESCENT; ADULT; AGED; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; CHROMOSOME 1; CHROMOSOME 15; CHROMOSOME 4; CONTROLLED STUDY; FEMALE; GENE CLUSTER; GENE INTERACTION; GENETIC EPISTASIS; GENETIC LINKAGE; GENOME ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ALCOHOL DEHYDROGENASE; ALCOHOLISM; CHILD; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 4; EPISTASIS, GENETIC; GENOTYPE; HUMANS; LINKAGE (GENETICS); MIDDLE AGED; PHENOTYPE; REGRESSION ANALYSIS; SIBLINGS;

EID: 55349106218     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30735     Document Type: Article

References (37)

1. Almasy L, Porjesz B, Blangero J, Goate A, Edenberg HJ, Chorlian DB, Kuperman S, et al. 2001. Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. Am J Hum Genet 68:128-135.
2. Babor TF, Hofmann M, DelBoca FK, Hesselbrock V, Meyer RE, Dolinsky ZS, Rounsaville B. 1992. Types of alcoholics. I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 49:599-608.
3. Begleiter H, Reich T, Hesselbrock V, Porjesz B, Li TK, Schuckit MA, Edenberg HJ, et al. 1995. The Collaborative Study on the Genetics of Alcoholism. Alcohol Health Res World 19:228-236.
4. Begleiter H, Porjesz B, Reich T, Edenberg HJ, Goate A, Blangero J, Almasy L, et al. 1998. Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. Electroencephalogr Clin Neurophysiol 108:244-250.
5. Bierut LJ, Rice JP, Goate A, Hinrichs AL, Saccone NL, Foroud T, Edenberg HJ, et al. 2004. A genomic scan for habitual smoking in families of alcoholics: Common and specific genetic factors in substance dependence. Am J Med Genet Part A 124A:19-27.
6. Boehnke M. 1991. Allele frequency estimation from data on relatives. Am J Hum Genet 48:22-25.
7. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI, Reich T, et al. 1994. A new semi-structured psychiatric interview for use in genetic linkage studies: A report of the reliability of SSAGA. J Stud Alcohol 55:149-158.
8. Bucholz KK, Hesselbrock VM, Shayka JJ, Nurnberger JI Jr, Schuckit MA, Schmidt I, Reich T. 1995. Reliability of individual diagnostic criterion items for psychoactive substance dependence and the impact on diagnosis. J Stud Alcohol 56:500-505.
9. Bucholz KK, Hesselbrock VM, Heath AC, Kramer JR, Schuckit MA. 2000. A latent class analysis of antisocial personality disorder symptom data from a multi-center family study of alcoholism. Addiction 95(4):553-567.
10. Cloninger CR, Bohman M, Sigvardsson S, Inheritance of alcohol abuse. 1981. Cross-fostering analysis of adopted men. Arch Gen Psychiatry 38:861-868.
11. Culverhouse R, Suarez BK, Lin J, Reich T. 2002. A perspective on epistasis: Limits of models displaying no main effect. Am J Hum Genet 70:461-471.
12. Dick DM, Li TK, Edenberg HJ, Hesselbrock V, Kramer J, Kuperman S, Porjesz B., et al. 2004. A Genome-Wide Screen for Genes Influencing Conduct Disorder. Mol Psychiatry 9:81-86.
13. Edenberg HJ, Bosron WF. 1997. Alcohol dehydrogenases. In: Guengerich FP, editor. Comprehensive toxicology, Vol. 3: Biotransformation, Chapter 3.08. New York: Pergamon.
14. Feighner JP, Robins E, Guze SB, Woodruff RA Jr, Winokur G, Munoz R. 1972. Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry 26:57-63.
15. Foroud T, Bucholz KK, Edenberg HJ, Goate A, Neuman RJ, Porjesz B, Koller DL, et al. 1998. Linkage of an alcoholism-related severity phenotype to chromosome 16. Alcohol Clin Exp Res 22:2035-2042.
16. Foroud T, Edenberg HJ, Goate A, Rice JP, Flury L, Koller DL, Bierut LJ, et al. 2000. Alcoholism susceptibility loci: Confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res 24:933-945.
17. Fulker DW, Cherny SS, Cardon LR. 1995. Multipoint interval mapping of quantitative trait loci using sib-pairs. Am J Hum Genet 56:1224-1233.
18. Ghosh S, Majumder PP. 2000. A two-stage variable stringency semi-parametric method for mapping quantitative trait loci with the use of genome-wide scan data on sib pairs. Am J Hum Genet 66:1046-1061.
19. Ghosh S, Reich T. 2002. Integrating sibship data for mapping quantitative trait loci. Ann Hum Genet 66:169-182.
20. Ghosh S, Begleiter H, Porjesz B, Chorlian D, Edenberg HJ, Foroud T, Goate A, et al. 2003. Linkage mapping of Beta 2EEG waves via non-parametric regression. Am J Med Genet 118:66-71.
21. Hesselbrock VM, Hesselbrock MN, Workman-Daniels KL. 1986. The effect of major depression and antisocial personality on alcoholism: Core use and motivational patterns. J Stud Alcohol 47(3):207-212.
22. Hesselbrock MN, Easton C, Bucholtz KK, Schuckit M, Hesselbrock VM. 1999. A validity study of the SSAGA - A comparison with the SCAN. Addiction 94:1361-1370.
23. Jones K, Porjesz B, Reich T, Almasy L, Bierut L, Goate A, Hinrichs A, et al. 2004. Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: Implications for human brain dynamics and cognition. Int J Pschophysiol 53(2):75-90.
24. Kendler KS, Prescott CA, Myers J, Neale MC. 1987. The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry 60:929-937.
25. Lander ES, Green P. 1987. Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci USA 84:2363-2367.
26. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, Bennett PH, et al. 1998. Evidence for genetic linkage to alcohol dependence on Chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81:216-221.
27. Myers MG, Brown SA, Mott MA. 1995. Preadolescent conduct disorder behaviors predict relapse and progression of addiction for adolescent alcohol and drug abusers. Alcohol Clin Exp Res 19:1528-1536.
28. Nurnberger JI Jr, Foroud T, Flury L, Su J, Meyer ET, Hu K, Crowe R, et al. 2001. Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. Am J Psychiatry 158:718-724.
29. Porjesz B, Begleiter H, Reich T, Van Eerdewegh P, Edenberg HJ, Foroud T, Goate A, et al. 1998. Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: Preliminary results from the COGA Project. Collaborative Study on the Genetics of Alcoholism. Alcohol Clin Exp Res 22(6):1317-1323.
30. Porjesz B, Almasy L, Edenberg HJ, Wang K, Chorlian D, Foroud T, Goate A, et al. 2002a. Linkage disequilibrium between the beta frequency of the human EEG and a GABA A receptor gene locus. Proc Natl Acad Sci USA 99:3729-3733.
31. Porjesz B, Begleiter H, Wang K, Almasy L, Chorlian D, Stimus AT, Kuperman S, et al. 2002b. Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes. Biol Psychol 61(1-2):229-248.
32. Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, Foroud T, et al. 1998. Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81:207-215.
33. Robins L. 1966. Deviant children grown up: A social and psychiatric study of sociopathic personality. Baltimore: Williams\& Wilkins.
34. Saccone NL, Kwon JM, Corbett J, Goate A, Rochberg N, Edenberg HJ, Foroud T, et al. 2000. A genome screen of maximum number of drinks as an alcoholism phenotype. Am J Med Genet 96:632-637.
35. Silverman BW. 1986. Density estimation for statistics and data analysis. London: Chapman and Hall.
36. Slutske WS, Heath AC, Dinwiddie SH, Madden PAF, Bucholz KK, Dunne MP, Statham DJ, et al. 1998. Common genetic risk factors for conduct disorder and alcohol dependence. J Abnorm Psychol 107:362-374.
37. Williams JT, Begleiter H, Porjesz B, Edenberg HJ, Foroud T, Reich T, Goate A, et al. 1999. Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. Am J Hum Genet 65:1148-1160.