Syntheses of AZ12320927 labeled with H-3, C-14, and H-2

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 51, Issue 9, 2008, Pages 343-346

  Elmore, Charles S ^a   Powell, Mark E ^a   Heys, J Richard ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

5 HT1B antagonist; Ir catalyzed exchange; Nucleophilic aromatic substitution

Indexed keywords

C (PROGRAMMING LANGUAGE); CATALYSIS; RADIOGRAPHY;

5-HT1B ANTAGONIST; A-STABLE; INTERNAL STANDARDS; IR-CATALYZED EXCHANGE; ISOTOPICALLY LABELED; LC-MS-MS; NUCLEOPHILIC AROMATIC SUBSTITUTION; P-NITROPHENOL; STABLE ISOTOPES; SYNTHESISED;

TRITIUM;

AZ 12320927; CARBON 14; DEUTERIUM; SEROTONIN 1B ANTAGONIST; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; AUTORADIOGRAPHY; DEPRESSION; DRUG DETERMINATION; DRUG INDICATION; DRUG RESEARCH; DRUG SYNTHESIS; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY;

EID: 55349099492     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1534     Document Type: Article

References (9)

1. M. Maes, H. Y. Meltzer in Psychopharmacology: The Fourth Generation of Progress (Eds.: F. E. Bloom, D. J. Kepfer), Raven Press Ltd., New York, 1995, pp. 933-945.
2. P. Blier, C. Montigny, Trends Pharmacol. Sci. 1994, 15, 220-226.
3. S. Halazy, M. Lamothe, C. Jorand-Lebrun, Expert Opin. Ther. Patents 1997, 7, 339-352.
4. M. Briley, C. Moret, Clin. Neuropharmacol. 1993, 16, 387-400.
5. S. Hjorth, C. S. Suchowski, M. P. Galloway, Synapse 1995, 19, 170-176D.
6. Hoyer, D. N. Middlemiss, Trends Pharmcol. Sci. 1989, 10, 130-132.
7. 5 during the reaction.
8. R. Salter, M. Chappelle, A. Morgan, T. Moenius, P. Ackermann, M. Studer, F. Spindler, in Synthesis and Applications of Isotopically Labelled Compounds, Vol. 7 (Eds.: U. Pleiss, R. Voges), 2001, pp. 63-67.
9. H. Kotsuki, S. Kobayashi, H. Suenaga, H. Nishizawa, Synthesis 1990, 1145-1148.