Up-regulation of activating transcription factor-5 suppresses SAP expression to activate T cells in hemophagocytic syndrome associated with Epstein-Barr virus infection and immune disorders

American Journal of Pathology

Volumn 173, Issue 5, 2008, Pages 1397-1405

  Chuang, Huai Chia ^a,b   Wang, Ju Ming ^b   Hsieh, Wen Chuan ^a   Chang, Yao ^a,b   Su, Ih Jen ^a,b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LATENT MEMBRANE PROTEIN 1; LIGAND; LUCIFERASE; PHYTOHEMAGGLUTININ; SIGNALING LYMPHOCYTE ACTIVATION MOLECULE ASSOCIATED PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 5 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; DISEASE ASSOCIATION; EPSTEIN BARR VIRUS; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; HEMOPHAGOCYTIC SYNDROME; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; LYMPHOCYTE ACTIVATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; UPREGULATION; VIRUS INFECTION;

EID: 55349096161     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2008.080440     Document Type: Article

References (36)

1. Su IJ, Chen RL, Lin DT, Lin KS, Chen CC: Epstein-Barr virus (EBV) infects T lymphocytes in childhood EBV-associated hemophagocytic syndrome in Taiwan. Am J Pathol 1994, 144:1219-1225
2. Cheung CY, Poon LL, Lau AS, Luk W, Lau YL, Shortridge KF, Gordon S, Guan Y, Peiris JS: Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet 2002, 360:1831-1837
3. Papo T, Andre MH, Amoura Z, Lortholary O, Tribout B, Guillevin L, Piette JC: The spectrum of reactive hemophagocytic syndrome in systemic lupus erythematosus. J Rheumatol 1999, 26:927-930
4. Wada Y, Kitajima H, Kubo M: Seven cases of hemophagocytic syndrome complicated with childhood collagen diseases. Ryumachi 1996, 36:637-643
5. Imashuku S, Hibi S, Fujiwara F, Ikushima S, Todo S: Haemophagocytic lymphohistiocytosis, interferon-gamma-anaemia and Epstein-Barr virus involvement. Br J Haematol 1994, 88:656-658
6. Lay JD, Tsao CJ, Chen JY, Kadin ME, Su IJ: Upregulation of tumor necrosis factor-alpha gene by Epstein-Barr virus and activation of macrophages in Epstein-Barr virus-infected T cells in the pathogenesis of hemophagocytic syndrome. J Clin Invest 1997, 100:1969-1979
7. Foss HD, Herbst H, Hummel M, Araujo I, Latza U, Rancso C, Dallenbach F, Stein H: Patterns of cytokine gene expression in infectious mononucleosis. Blood 1994, 83:707-712
8. Ohga S, Matsuzaki A, Nishizaki M, Nagashima T, Kai T, Suda M, Ueda K: Inflammatory cytokines in virus-associated hemophagocytic syndrome. Interferon-gamma as a sensitive indicator of disease activity. Am J Pediatr Hematol Oncol 1993, 15:291-298
9. Mizuhara H, O'Neill E, Seki N, Ogawa T, Kusunoki C, Otsuka K, Satoh S, Niwa M, Senoh H, Fujiwara H: T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med 1994, 179:1529-1537
10. Su IJ, Wang CH, Cheng AL, Chen RL: Hemophagocytic syndrome in Epstein-Barr virus-associated T-lymphoproliferative disorders: disease spectrum, pathogenesis, and management. Leuk Lymphoma 1995, 19:401-406
11. Hsieh WC, Chen CR, Lin YH, Hayashi K, Su IJ: Emergence of heterophile antibodies precipitates phagocytosis of red cells by macrophages in EBV-associated hemophagocytic syndrome. Am J Pathol 2007; 70:1629-1639
12. Coffey AJ, Brooksbank RA, Brandau O, Oohashi T, Howell GR, Bye JM, Cahn AP, Durham J, Heath P, Wray P, Pavitt R, Wilkinson J, Leversha M, Huckle E, Shaw-Smith CJ, Dunham A, Rhodes S, Schuster V, Porta G, Yin L, Serafini P, Sylla B, Zollo M, Franco B, Bolino A, Seri M, Lanyi A, Davis JR, Webster D, Harris A, Lenoir G, de St Basile G, Jones A, Behloradsky BH, Achatz H, Murken J, Fassler R, Sumegi J, Romeo G, Vaudin M, Ross MT, Meindl A, Bentley DR: Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet 1998, 20:129-135
13. Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 1998, 395:462-469
14. Czar MJ, Kersh EN, Mijares LA, Lanier G, Lewis J, Yap G, Chen A, Sher A, Duckett CS, Ahmed R, Schwartzberg PL: Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc Natl Acad Sci USA 2001, 98:7449-7454
15. Wu C, Nguyen KB, Pien GC, Wang N, Gullo C, Howie D, Sosa MR, Edwards MJ, Borrow P, Satoskar AR, Sharpe AH, Biron CA, Terhorst C: SAP controls T cell responses to virus and terminal differentiation of TH2 cells. Nat Immunol 2001, 2:410-414
16. Chuang HC, Lay JD, Hsieh WC, Wang HC, Chang Y, Chuang SE, Su IJ: Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome. Blood 2005, 106:3090-3096
17. Jost PJ, Ruland J: Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood 2007, 109:2700-2707
18. Mokrani H, Sharaf el Dein O, Mansuroglu Z, Bonnefoy E: Binding of YY1 to the proximal region of the murine beta interferon promoter is essential to allow CBP recruitment and K8H4/K14H3 acetylation on the promoter region after virus infection. Mol Cell Biol 2006, 26:8551-8561
19. Weill L, Shestakova E, Bonnefoy E: Transcription factor YY1 binds to the murine beta interferon promoter and regulates its transcriptional capacity with a dual activator/repressor role. J Virol 2003, 77:2903-2914
20. Galloway DA, Gewin LC, Myers H, Luo W, Grandori C, Katzenellenbogen RA, McDougall JK: Regulation of telomerase by human papillomaviruses. Cold Spring Harb Symp Quant Biol 2005, 70:209-215
21. Coull JJ, Romerio F, Sun JM, Volker JL, Galvin KM, Davie JR, Shi Y, Hansen U, Margolis DM: The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1. J Virol 2000, 74:6790-6799
22. Matsumoto J, Ohshima T, Isono O, Shimotohno K: HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene 2005, 24:1001-1010
23. Chuang HC, Lay JD, Chuang SE, Hsieh WC, Chang Y, Su IJ: Epstein-Barr virus (EBV) latent membrane protein-1 down-regulates tumor necrosis factor-alpha (TNF-alpha) receptor-1 and confers resistance to TNF-alpha-induced apoptosis in T cells: implication for the progression to T-cell lymphoma in EBV-associated hemophagocytic syndrome. Am J Pathol 2007, 170:1607-1617
24. Flammer JR, Popova KN, Pflum MK: Cyclic AMP response element-binding protein (CREB) and CAAT/enhancer-binding protein beta (C/EBPbeta) bind chimeric DNA sites with high affinity. Biochemistry 2006, 45:9615-9623
25. Aringer M, Smolen JS: Cytokine expression in lupus kidneys. Lupus 2005, 14:13-18
26. Lit LC, Wong CK, Li EK, Tam LS, Lam CW, Lo YM: Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus. J Rheumatol 2007, 34:89-96
27. Pati D, Meistrich ML, Plon SE: Human Cdc34 and Rad6B ubiquitin- conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. Mol Cell Biol 1999, 19:5001-5013
28. Dadmanesh F, Peterse JL, Sapino A, Fonelli A, Eusebi V: Lympho-epithelioma-like carcinoma of the breast: lack of evidence of Epstein-Barr virus infection. Histopathology 2001, 38:54-61
29. Angelastro JM, Ignatova TN, Kukekov VG, Steindler DA, Stengren GB, Mendelsohn C, Greene LA: Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons. J Neurosci 2003, 23:4590-4600
30. Chérasse Y, Maurin AC, Chaveroux C, Jousse C, Carraro V, Parry L, Deval C, Chambon C, Fafournoux P, Bruhat A: The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP. Nucleic Acids Res 2007, 35:5954-5965
31. Asano Y, Czuwara J, Trojanowska M: Transforming growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylation. J Biol Chem 2007, 282:34672-34683
32. Nagy N, Takahara M, Nishikawa J, Bourdon JC, Kis LL, Klein G, Klein E: Wild-type p53 activates SAP expression in lymphoid cells. Oncogene 2004, 23:8563-8570
33. Tsukada J, Saito K, Waterman WR, Webb AC, Auron PE: Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene. Mol Cell Biol 1994, 14:7285-7297
34. Rosenthal KS, Shuman H, Strominger JL: Induction of several new antigens, including a T cell-associated antigen, following conversion of the EBV-negative B cell line RAMOS to EHRB-RAMOS by Epstein-Barr virus. J Immunol 1981, 127:746-754
35. Edelman GM, Meech R, Owens GC, Jones FS: Synthetic promoter elements obtained by nucleotide sequence variation and selection for activity. Proc Natl Acad Sci USA 2000, 97:3038-3043
36. Williams JS, Andrisani OM: The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB. Proc Natl Acad Sci USA 1995, 92:3819-3823