Role of oxygen availability in CFTR expression and function

American Journal of Respiratory Cell and Molecular Biology

Volumn 39, Issue 5, 2008, Pages 514-521

  Guimbellot, Jennifer S ^a,f   Fortenberry, James A ^f   Siegal, Gene P ^c,d,e   Moore, Bryan ^g   Wen, Hui ^f   Venglarik, Charles ^f   Chen, Yiu Fai ^b   Oparil, Suzanne ^b   Sorscher, Eric J ^a,b,c,f   Hong, Jeong S ^c,f,h  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d University of Alabama at Birmingham   (United States)

^e Kentucky   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^g MOTOROLA INC   (United States)

^h NONE   (United States)

Author keywords

Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Hypoxia

Indexed keywords

OXYGEN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHLORIDE TRANSPORT; DISEASE COURSE; ENVIRONMENTAL FACTOR; FEMALE; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; HYPOXIC LUNG VASOCONSTRICTION; IN VITRO STUDY; IN VIVO STUDY; LUNG FIBROSIS; LUNG PARENCHYMA; LUNG TRANSPLANTATION; MALE; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL HYPOXIA; CELL LINE; CULTURE MEDIUM; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

MUS;

ANIMALS; CELL HYPOXIA; CELL LINE; CULTURE MEDIA, CONDITIONED; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED C57BL; OXYGEN;

EID: 55249113003     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2007-0452OC     Document Type: Article

References (53)

1. Rowe SM, Miller S, Sorscher EJ. Cystic fibrosis. N Engl J Med 2005;352:1992-2001.
2. Worlitzsch D, Tarran R, Ulrich M, Schwab U, Cekici A, Meyer KC, Birrer P, Bellon G, Berger J, Weiss T, et al. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest 2002;109:317-325.
3. Semenza GL. Involvement of hypoxia-inducible factor 1 in pulmonary pathophysiology. Chest 2005;128:592S-594S.
4. Semenza GL. Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1. Proc Am Thorac Soc 2005;2:68-70.
5. Kwapiszewska G, Wilhelm J, Wolff S, Laumanns I, Koenig IR, Ziegler A, Seeger W, Bohle RM, Weissmann N, Fink L. Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension. Respir Res 2005;6:109.
6. Tong Q, Zheng L, Lin L, Li B, Wang D, Huang C, Li D. VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway. Respir Res 2006;7:37.
7. Jain M, Sznajder JI. Effects of hypoxia on the alveolar epithelium. Proc Am Thorac Soc 2005;2:202-205.
8. Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. Am J Physiol 1998;275:L818-L826.
9. Cole LA, Scheid JM, Tannen RL. Induction of mitochondrial metabolism and pH-modulated ammoniagenesis by rocking LLC-PK1 cells. Am J Physiol 1986;251:C293-C298.
10. Dickman KG, Mandel LJ. Glycolytic and oxidative metabolism in primary renal proximal tubule cultures. Am J Physiol 1989;257:C333-C340.
11. Nowak G, Schnellmann RG. Improved culture conditions stimulate gluconeogenesis in primary cultures of renal proximal tubule cells. Am J Physiol 1995;268:C1053-C1061.
12. Ohno K, Maier P. Cultured rat hepatocytes adapt their cellular glycolytic activity and adenylate energy status to tissue oxygen tension: influences of extracellular matrix components, insulin and glucagon. J Cell Physiol 1994;160:358-366.
13. Sahai A, Cole LA, Clarke DL, Tannen RL. Rocking promotes differentiated properties in LLC-PK cells by improved oxygenation. Am J Physiol 1989;256:C1064-C1069.
14. Stevens KM. Oxygen requirements for liver cells in vitro. Nature 1965;206:199.
15. Werrlein RJ, Glinos AD. Oxygen microenvironment and respiratory oscillations in cultured mammalian cells. Nature 1974;251:317-319.
16. Dorris DR, Ramakrishnan R, Trakas D, Dudzik F, Belval R, Zhao C, Nguyen A, Domanus M, Mazumder A. A highly reproducible, linear, and automated sample preparation method for DNA microarrays. Genome Res 2002;12:976-984.
17. Ramakrishnan R, Dorris D, Lublinsky A, Nguyen A, Domanus M, Prokhorova A, Gieser L, Touma E, Lockner R, Tata M, et al. An assessment of Motorola CodeLink microarray performance for gene expression profiling applications. Nucleic Acids Res 2002;30:e30.
18. Venglarik CJ, Dawson DC. Cholinergic regulation of Na absorption by turtle colon: role of basolateral K conductance. Am J Physiol 1986;251:C563-C570.
19. Chen YF, Feng JA, Li P, Xing D, Ambalavanan N, Oparil S. Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling. Life Sci 2006;79:1357-1365.
20. Chen YF, Feng JA, Li P, Xing D, Zhang Y, Serra R, Ambalavanan N, Majid-Hassan E, Oparil S. Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling. J Appl Physiol 2006;100:564-571.
21. Arthur C, Hall JE. Textbook of medical physiology, 10th ed. Ch. 43: aviation, high-altitude, and space physiology. Philadelphia: W. B. Saunders Company; 2000. pp. 496-498.
22. Ruiz FE, Clancy JP, Perricone MA, Bebok Z, Hong JS, Cheng SH, Meeker DP, Young KR, Schoumacher RA, Weatherly MR, et al. A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis. Hum Gene Ther 2001;12:751-761.
23. Ostrowski LE, Nettesheim P. Inhibition of ciliated cell differentiation by fluid submersion. Exp Lung Res 1995;21:957-970.
24. Gruenert DC, Willems M, Cassiman JJ, Frizzell RA. Established cell lines used in cystic fibrosis research. J Cyst Fibros 2004;3:191-196.
25. Ivanov S, Liao SY, Ivanova A, Danilkovitch-Miagkova A, Tarasova N, Weirich G, Merrill MJ, Proescholdt MA, Oldfield EH, Lee J, et al. Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol 2001;158:905-919.
26. Potter C, Harris AL. Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target. Cell Cycle 2004;3:164-167.
27. Jean JC, Rich CB, Joyce-Brady M. Hypoxia results in an HIF-1-dependent induction of brain-specific aldolase C in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2006;291:L950-L956.
28. Ivan M, Haberberger T, Gervasi DC, Michelson KS, Gunzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW, et al. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci USA 2002;99:13459-13464.
29. Yuan Y, Hilliard G, Ferguson T, Millhorn DE. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J Biol Chem 2003;278:15911-15916.
30. Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Gunzler V, White CW. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc Natl Acad Sci USA 2005;102:10212-10217.
31. Koivunen P, Hirsila M, Gunzler V, Kivirikko KI, Myllyharju J. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem 2004;279:9899-9904.
32. Elvidge GP, Glenny L, Appelhoff RJ, Ratcliffe PJ, Ragoussis J, Gleadle JM. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate- dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J Biol Chem 2006;281:15215-15226.
33. Wiener CM, Booth G, Semenza GL. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem Biophys Res Commun 1996;225:485-488.
34. Bebok Z, Varga K, Hicks JK, Venglarik CJ, Kovacs T, Chen L, Hardiman KM, Collawn JF, Sorscher EJ, Matalon S. Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl- secretion in airway epithelia. J Biol Chem 2002;277:43041-43049.
35. Amaral MD. Processing of CFTR: traversing the cellular maze-how much CFTR needs to go through to avoid cystic fibrosis? Pediatr Pulmonol 2005;39:479-491.
36. Ramalho AS, Beck S, Meyer M, Penque D, Cutting GR, Amaral MD. Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis. Am J Respir Cell Mol Biol 2002;27:619-627.
37. De Braekeleer M, Allard C, Leblanc JP, Simard F, Aubin G. Genotype-phenotype correlation in cystic fibrosis patients compound heterozygous for the A455E mutation. Hum Genet 1997;101:208-211.
38. Bronsveld I, Mekus F, Bijman J, Ballmann M, de Jonge HR, Laabs U, Halley DJ, Ellemunter H, Mastella G, Thomas S, et al. Chloride conductance and genetic background modulate the cystic fibrosis phenotype of Delta F508 homozygous twins and siblings. J Clin Invest 2001;108:1705-1715.
39. Drumm M. What happens to deltaF508 in vivo? J Clin Invest 1999;103:1369-1370.
40. Kalin N, Claass A, Sommer M, Puchelle E, Tummler B. DeltaF508 CFTR protein expression in tissues from patients with cystic fibrosis. J Clin Invest 1999;103:1379-1389.
41. Kelley TJ, Al-Nakkash L, Cotton CU, Drumm ML. Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition. J Clin Invest 1996;98:513-520.
42. Kelley TJ, Thomas K, Milgram LJ, Drumm ML. In vivo activation of the cystic fibrosis transmembrane conductance regulator mutant deltaF508 in murine nasal epithelium. Proc Natl Acad Sci USA 1997;94:2604-2608.
43. Arkwright PD, Laurie S, Super M, Pravica V, Schwarz MJ, Webb AK, Hutchinson IV. TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis. Thorax 2000;55:459-462.
44. Drumm ML, Konstan MW, Schluchter MD, Handler A, Pace R, Zou F, Zariwala M, Fargo D, Xu A, Dunn JM, et al. Genetic modifiers of lung disease in cystic fibrosis. N Engl J Med 2005;353:1443-1453.
45. Bebok Z, Tousson A, Schwiebert LM, Venglarik CJ. Improved oxygenation promotes CFTR maturation and trafficking in MDCK monolayers. Am J Physiol Cell Physiol 2001;280:C135-C145.
46. Cantin AM, Hanrahan JW, Bilodeau G, Ellis L, Dupuis A, Liao J, Zielenski J, Durie P. Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers. Am J Respir Crit Care Med 2006;173:1139-1144.
47. Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, et al. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J 2006;25:1114-1125.
48. van den Beucken T, Koritzinsky M, Wouters BG. Translational control of gene expression during hypoxia. Cancer Biol Ther 2006;5:749-755.
49. Mairbaurl H, Schwobel F, Hoschele S, Maggiorini M, Gibbs S, Swenson ER, Bartsch P. Altered ion transporter expression in bronchial epithelium in mountaineers with high-altitude pulmonary edema. J Appl Physiol 2003;95:1843-1850.
50. Hochachka PW, Buck LT, Doll CJ, Land SC. Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc Natl Acad Sci USA 1996;93:9493-9498.
51. Buck LT, Hochachka PW. Anoxic suppression of Na(+)-K(+)-ATPase and constant membrane potential in hepatocytes: support for channel arrest. Am J Physiol 1993;265:R1020-R1025.
52. Clerici C, Matthay MA. Hypoxia regulates gene expression of alveolar epithelial transport proteins. J Appl Physiol 2000;88:1890-1896.
53. Zaidi T, Mowrey-McKee M, Pier GB. Hypoxia increases corneal cell expression of CFTR leading to increased Pseudomonas aeruginosa binding, internalization, and initiation of inflammation. Invest Ophthalmol Vis Sci 2004;45:4066-4074.