Activated prorenin as a therapeutic target for diabetic nephropathy

Diabetes Research and Clinical Practice

Volumn 82, Issue SUPPL. 1, 2008, Pages

  Ichihara, Atsuhiro ^a   Sakoda, Mariyo ^a   Mito Kurauchi, Asako ^a   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiotensin; db db mouse; Mitogen activated protein kinases; Non proteolytic activation; Streptozotocin

Indexed keywords

ALBUMIN; ANGIOTENSIN 1A RECEPTOR; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PRORENIN;

ARTICLE; DIABETIC NEPHROPATHY; ENZYME INHIBITION; HUMAN; HYPERTENSION; INSULIN DEPENDENT DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEINURIA; RECEPTOR BINDING; REMISSION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; URINARY EXCRETION;

ANIMALS; DIABETIC NEPHROPATHIES; DRUG DELIVERY SYSTEMS; HUMANS; RECEPTORS, CELL SURFACE; RENIN;

EID: 55249108889     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2008.09.027     Document Type: Article

References (21)

1. Derkx F., and Schalekamp M. Human prorenin: pathophysiology and clinical implications. Clin. Exp. Hypertens. A10 (1988) 1213-1225
2. Wilson D., and Leutscher J.A. Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus. N. Engl. J. Med. 323 (1990) 1101-1106
3. Deinum J., Roon B., Mathiesen E., Derkx F.H.M., Hop W.C.J., and Schalekamp M.A.D.H. Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus. Diabetologia 42 (1999) 1006-1010
4. Nguyen G., Delarue F., Burckle C., Bouzhir L., Giller T., and Sraer J.-D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to rennin. J. Clin. Invest. 109 (2002) 1417-1427
5. Huang Y., Wongamorntham S., Kasting J., McQuillan D., Owens R.T., Yu L., et al. Renin increases mesangial cell transforming growth factor-b1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int. 69 (2006) 105-113
6. Ichihara A., Kaneshiro Y., Takemitsu T., Sakoda M., and Itoh H. The (pro)renin receptor and the kidney. Semin. Nephrol. 27 (2007) 524-528
7. Nabi A.H.M.N., Kageshima A., Uddin M., Nakagawa T., Park E., and Suzuki F. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int. J. Mol. Med. 18 (2006) 483-488
8. Suzuki F., Hayakawa M., Nakagawa T., Nasir U.M., Ebihara A., Iwasawa A., et al. Human prorenin has "gate and handle" regions for its non-proteolytic activation. J. Biol. Chem. 278 (2003) 22217-22222
9. Sakoda M., Ichihara A., Kaneshiro Y., Takemitsu T., Nakazato Y., Migita T., et al. (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells. Hyper. Res. 30 (2007) 1139-1146
10. Huang Y., Noble N., Zhang J., Xu C., and Border W. Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int. 72 (2007) 42-52
11. Saris J., 'tHoen P., Garrelds I., Dekkers D., denDunnen J., Lamers J., et al. Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension 48 (2006) 564-571
12. Nabi A.H.M.N., Uddin M., Nakagawa T., Iwata H., Ichihara A., Inagami T., et al. Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor. Front Biosci. 12 (2007) 4810-4817
13. Ichihara A., Hayashi M., Kaneshiro Y., Suzuki F., Nakagawa T., Tada Y., et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for non-proteolytic activation of prorenin. J. Clin. Invest. 114 (2004) 1128-1135
14. Takahashi H., Ichihara A., Kaneshiro Y., Inomata K., Sakoda M., Takemitsu T., et al. Regression of nephropathy developed in diabetes by (pro)renin receptor blockade. J. Am. Soc. Nephrol. 18 (2007) 2054-2061
15. Ichihara A., Suzuki F., Nakagawa T., Kaneshiro Y., Takemitsu T., Sakoda M., et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor deficient mice. J. Am. Soc. Nephrol. 17 (2006) 1950-1961
16. Ichihara A., Sakoda M., Mito-Kurauchi A., Nishiyama A., and Itoh H. Involvement of receptor-bound prorenin in development of nephropathy in db/db mice. J. Am. Soc. Hypertens. 2 (2008) 332-340
17. Ichihara A., Kaneshiro Y., Takemitsu T., Sakoda M., Suzuki F., Nakagawa T., et al. Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 47 (2006) 894-900
18. Ichihara A., Kaneshiro Y., Takemitsu T., Sakoda M., Nakagawa T., Nishiyama A., et al. Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage. J. Am. Soc. Nephrol. 17 (2006) 2495-2503
19. Schefe J., Menk M., Reinemund J., Effertz K., Hobbs R., Pandolfi P., et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ. Res. 99 (2006) 1355-1366
20. Krebs C., Hamming I., Sadaghiani S., Steinmetz O.M., Meyer-Schwesinger C., Fehr S., et al. Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats. Kidney Int. 72 (2007) 725-730
21. Batenburg W.W., Krop M.K., Garrelds I.M., deVries R., deBruin R.J.A., Burckle C.A., et al. Prorenin is the endogenous agonist of the (pro)renin receptor binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J. Hypertens. 25 (2007) 2441-2453