The effect of Ginkgo biloba (EGb 761) on epileptic activity in rabbits

Molecules

Volumn 13, Issue 10, 2008, Pages 2509-2520

  Ivetic, Vesna ^a   Popovic, Mira ^b   Naumovic, Nada ^a   Radenkovic, Mirjana ^c   Vasic, Vesna ^a  

^a UNIVERSITY OF NOVI SAD   (Serbia)

^b UNIVERSITY OF NOVI SAD   (Serbia)

^c UNIVERSITY OF NI   (Serbia)

Author keywords

EGb 761; Ginkgo biloba; Kindling epilepsy; Rabbits

Indexed keywords

GINKGO BILOBA EXTRACT 761; PLANT EXTRACT;

ANIMAL; ARTICLE; CHEMISTRY; ELECTROENCEPHALOGRAPHY; ELECTROSTIMULATION; EPILEPSY; GINKGO BILOBA; HIPPOCAMPUS; KINDLING; PATHOPHYSIOLOGY; RABBIT;

ANIMALS; ELECTRIC STIMULATION; ELECTROENCEPHALOGRAPHY; EPILEPSY; GINKGO BILOBA; HIPPOCAMPUS; KINDLING, NEUROLOGIC; PLANT EXTRACTS; RABBITS;

EID: 55249097855     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules13102509     Document Type: Article

References (41)

1. Goddard, G.V. Development of epileptic seizures through brain stimulation at low intensity. Nature 1967, 214, 1020-1021.
2. Goddard, G.V.; McIntyre, D.C.; Leech, C.K. A permanent change in brain function resulting from daily electrical stimulation. Exp. Neurol. 1969, 25, 295-330.
3. Wada, J.A.; Sato, M.; Corcoran, M.E. Persistent seizure susceptibility and recurrent spontaneous seizures in kindled rats. Epilepsia 1974, 15, 465-781.
4. Abel, M. S.; McCandless, D. W. Animal Models of Neurological Disease, II: Metabolic Encephalopathies and the Epilepsies, Boulton, Alan A., Baker, Glen B., Butterworth, Roger F. , Eds.; The Humana Press Inc.: Totowa, NJ, USA, 1992; pp. 153-168.
5. Racine, R.J. Modification of seizure activity by electrical stimulation, II: motor seizure. Electroencephalogr. Clin. Neurophysiol. 1972, 32, 281-294.
6. Racine, R.J. Modification of seizure activity by electrical stimulation, I: after-discharge threshold. . Electroencephalogr. Clin. Neurophysiol. 1972, 32, 269-279.
7. Dennison, Z.; Teskey, G.C.; Cain, D.P. Persistence of kindling:effect of partial kindling, retention interval, kindling site, and stimulation parameters. Epilepsy Res. 1995, 21, 171-182.
8. Mirnajafi-Zadeh, J.; Pourgholami, M. Hippocampal hyperexcitability facilitates amygdala kindling in rats. Indian J. Med. Res. 2002, 7, 1.
9. Ivetic, V.; Popovic, M.; Mimica-Dukic, N.; Barak, O.; Pilija, V. St. Johnsons wort (Hypericum perforatum L.) and kindling epilepsy in rabbit. Phytomedicine 2002, 9, 496-499.
10. Burton, J.M.; Peebles, G.A.; Binder, D.K.; Rothman, S.M.; Smyth, M.D. Transcortical Cooling Inhibits hippocampal-kindled seizures in rats. Epilepsia 2005, 46, 1881-1887.
11. Heinrich, M.; Barnes, J.; Gibbons, S.; Williamson, E. Fundamentals of pharmacognosy and phytotherapy; Churchill Livingstone: Edinburgh, UK, 2004; p. 243.
12. Wold, R.S.; Lopez, S.T.; Yau, C.L., Butler L.M., Pareo S.R.; Increasing trends in elderly persons' use of nonvitamin, nonmineral dietary supplements and concurrent use of medications. J. Am. Diet. Assoc. 2005, 105, 54-63.
13. Drieu, K.; Jaggy, H. History, development and constituents of EGb 761. In Ginkgo Biloba; van Beek, T.A., Ed.; Harwood Academic Publishers: Amsterdam, The Netherlands, 2000; Volume 12, pp. 267-277.
14. Jaracz, S.; Malik, S.; Nakanishi, K. Isolation of ginkgolides A,B,C,J and bilobalide from G. Biloba extracts. Phytochem. 2004, 65, 2897-2902.
15. Le Bars, P.L.; Katz, M.M.; Bermann, N.; Itil, T.M.; Friedman, A.; Schatzberg, A.F. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA. 1997, 278, 1327-32.
16. Mix, J.A.; Crews, W.D. An examination of the efficacy of Ginkgo biloba extract EGb761 on the neuropsychologic functioning of cognitively intact older adults. J. Altern. Complement. Med. 2000, 6, 219-229.
17. Drieu, K.; Vranckx, R.; Benassayad, C.; Haourigi, M.; Hassid, J.; Yoa, R.G.; Rapin, J.R.; Nunez, E.A. Effect of the extract of Ginkgo biloba (EGb 761) on the circulating and cellular profiles of polyunsaturated fatty acids: correlation with the anti-oxidant properties of the extract. Prostagland. Leukot. Essent. Fatty Acids. 2000, 63, 293-300.
18. Smith, P.F.; Maclennan, K.; Darlington, C.L. The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). J. Ethnopharmacol. 1996, 50, 131-139.
19. Ferrandini, C.; Droy-Lefaix, M.T.; Christen, Y. Ginkgo biloba Extract (EGb 761) as a Free Radical Scavenger. Elsevier: Paris, France, 1993.
20. Bridi, R.; Crossetti, F.P.; Steffen, V.M.; Henriques, A.T. The antioxidant activity of standardiyed extract of Ginkgo biloba (EGb 761) in rats. Phytother. Res. 2001, 15, 449-451.
21. Naik, S.R.; Pilgaonkar, V.W.; Panda, V.S. Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain. Phytother. Res. 2006, 20, 1013-1016.
22. Shah, Z.A.; Sharma, P.; Vohora, S.B. Ginkgo biloba normalises stress-elevated alterations in brain catecholamines, serotonin and plasma corticosterone levels, Eur. Neuropsychopharmacol. 2003, 13, 321-325.
23. Johnston, A.R.G. GABA Receptor Channel Pharmacology. Curr. Pharm. Des.. 2005, 11, 1867-1885.
24. Ivetic, V.; Popovic, M.; Pilija, V.; Hodolic, M.; Naumović, N. Ginkgo biloba and epilepsy. 6th European Congress on Epileptology, Vienna, Austria, 2004; Epilepsia 2004, 45, p. 239.
25. Manocha, A.; Pillai, K.K.; Husain, S. Z. Influence of Ginkgo Biloba on the effect of anticonvulsants. Indian J. Pharmacol. 1996, 28, 84-87.
26. Manocha, A.; Pillai, K.K.; Husain, S.Z. Effect of Ginkgo biloba on chemoshock in mice. Indian J. Pharmacol. 1997, 29, 198-200.
27. Gregory, P.J. Seizure associated with Ginkgo biloba. Ann. Intern. Med. 2001, 134, 344.
28. Granger, A.S. Ginkgo biloba precipitating epileptic seizures. Age Ageing 2001, 30, 523-525.
29. Kajiyama, Y.; Fujii, K.; Takeuchi, H.; Manabe, Y. Ginkgo seed poisoning Pediatrics 2002, 109, 325-327.
30. Miwa, H.; Iijima, M.; Tanaka, S.; Mizuno, Y. Generalized convulsions after consuming a large amount of gingko nuts. Epilepsia 2001, 42, 280-281.
31. Harms, S. L.; Garrard, J.; Schwinghammer, P.; Eberly, L.E.; Chang, Y.; Leppik, I.E. Ginkgo biloba Use in Nursing Home Elderly with Epilepsy or Seizure Disorder. Epilepsia 2006, 47, 323-329.
32. Gertz, H.J.; Kiefer, M. Review about Ginkgo Biloba Special Extract EGb 761 (Ginkgo). Curr. Pharm. Des. 2004, 4, 261-264.
33. Stough, C.; Ckarke, J.; Lloyd, J.; Nathan, P.J. Neuropsychological changes after 30-day Ginkgo biloba administration in healthy participants. Int. J. Neuropsychopharmacology. 2001, 4, 131-134.
34. Petkov, V.D.; Belcheva, S.; Petkov, V.V. Behavioral Effects of Ginkgo biloba L., Panax ginseng C.A. Mey. and Gincosan. Am. J. Chin. Med. 2003, 31, 841-855.
35. Chandrasekaran, K.; Mehrabian, Z.; Spinnewzn, B.; Drieu, K.; Fiskum, G. Neuroprocective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia. Brain Res. 2001, 282-292.
36. Sasaki, K.; Hatta, S.; Wada, K.; Ohshika, H. Bilobalide prevents reduction of ?-aminobutyric acid levels and glutamic acid decarboxylase activity induced by 4-O-methylpyridoxine in mouse hippocampus. Life Sci. 2000, 67, 709-715.
37. Huang, S.H.; Duke, R.K.; Chebib, M.; Sasaki, K.; Wada, K.; Johnston, GAR Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha(1)beta(2)gamma(2L) GABAA receptors. Eur. J. Pharmacol. 2003, 464, 1-8.
38. Heim, K.E.; Tagliaferro, A.R.; Bobilzya, D.J. Flavonoid antioxidans chemistry, metabolism and structure-activity relationships. J. Nutr. Biochem. 2002, 2, 853-867.
39. Nooshinfar, E.; Lashgari, R.; Haghparast, A.; Sajjadi, N. NMDA receptors are involved in Ginkgo extract-induced facilitation on memory retention of passive avoidance learning in rats. Neurosci. Lett. 2008, 432, 206-211.
40. Hadjiivanova, C.I.; Petkov, V.V. Effect of Ginkgo biloba extract on beta-adrenergic receptors in different rat brain regions. Phytother. Res. 2002, 16, 488-90.
41. Shek, J. W.; Wen, G. Y.; Wisniewski, H. M. Atlas of the Rabbit Brain and Spinal Cord. Karger: Basel, Switzerland, 1986; pp. 139, 235.