Lab-on-a-chip technologies for proteomic analysis from isolated cells

Journal of the Royal Society Interface

Volumn 5, Issue SUPPL.2, 2008, Pages

  Sedgwick, H ^a   Caron, F ^a   Monaghan, P B ^a,b   Kolch, W ^a,c   Cooper, J M ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b Vivacta Limited   (United Kingdom)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Lab on a chip; Proteomics; Single cell

Indexed keywords

ELECTROPHORESIS; FLUORESCENCE MICROSCOPY; MICROELECTRODES; MOLECULAR BIOLOGY; PROTEINS;

CONFOCAL FLUORESCENCE MICROSCOPY; LAB-ON-A-CHIP DEVICES; LAB-ON-A-CHIP SYSTEMS; LAB-ON-A-CHIP TECHNOLOGY; MICRO-FLUIDIC DEVICES; PROTEOMIC ANALYSIS; PROTEOMICS; SINGLE CELLS;

LAB-ON-A-CHIP;

ACTIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN;

ARTICLE; CELL SEPARATION; ELECTROPORATION; FLUORESCENCE MICROSCOPY; HUMAN; INSTRUMENTATION; METHODOLOGY; MICROCHIP ELECTROPHORESIS; PROTEOMICS; TUMOR CELL LINE;

ACTINS; CELL LINE, TUMOR; CELL SEPARATION; ELECTROPHORESIS, MICROCHIP; ELECTROPORATION; GREEN FLUORESCENT PROTEINS; HUMANS; MICROSCOPY, FLUORESCENCE; PROTEOMICS; RECOMBINANT FUSION PROTEINS;

EID: 55249095643     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2008.0169.focus     Document Type: Article

References (57)

1. Andersson, H. & van der Berg, A. 2003 Microfluidic devices for cellomics: a review. Sens. Actuators B 92, 315-325. (doi:10.1016/S0925-4005(03) 00266-1)
2. Andersson, H. & van der Berg, A. 2004 Microtechnologies and nanotechnologies for single-cell analysis. Curr. Opin. Biotechnol. 15, 44-49. (doi:10.1016/j.copbio.2004.01.004)
3. Bantscheff, M. et al. 2007 Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat. Biotechnol. 25, 1035-1044. (doi:10.1038/nbt1328)
4. Becker, F., Wang, X., Huang, Y., Pethig, R., Vykoukal, J. & Gascoyne, P. 1995 Separation of human breast cancer cells from blood by differential dielectric affinity. Proc. Natl Acad. Sci. USA 92, 860-864. (doi:10.1073/pnas. 92.3.860)
5. Beebe, D. J., Mensing, G. A. & Walker, G. M. 2002 Physics and applications of microfluidics in biology. Annu. Rev. Biomed. Eng. 4, 261-286. (doi:10.1146/annurev.bioeng.4.112601.125916)
6. Belgrader, P. et al. 1999 A minisonicator to rapidly disrupt bacterial spores for DNA analysis. Anal. Chem. 71, 4232-4236. (doi:10.1021/ac990347o)
7. Bhalla, U. S., Ram, P. T. & Iyengar, R. 2002 MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297, 1018-1023. (doi:10.1126/science.1068873)
8. Blohm, D. H. & Guiseppi-Elie, A. 2001 New developments in microarray technology. Curr. Opin. Biotechnol. 12, 41-47. (doi:10.1016/S0958-1669(00)00175- 0)
9. Cai, X., Klauke, N., Glidle, A., Cobbold, P., Smith, G. & Cooper, J. M. 2002 Ultra-low-volume, real-time measurements of lactate from the single heart cell using microsystems technology. Anal. Chem. 74, 908-914. (doi:10. 1021/ac010941C)
10. Carlson, R., Gabel, C., Chan, S. & Austin, R. 1997 Self-sorting of white blood cells in a lattice. Phys. Rev. Lett. 79, 2149-2152. (doi:10.1103/PhysRevLett.79.2149)
11. Chang, D. C., Chassy, B. M. & Saunders, J. A. 1992 Guide to electroporation and electrofusion. San Diego, CA: Academic Press.
12. Davalos, R., Huang, Y. & Rubinsky, B. 2000 Electroporation: bioelectrochemical mass transfer at the nanoscale. Micro-scale Thermophys. Eng. 4, 147-159. (doi:10.1080/10893950050148115)
13. Dolník, V., Liu, S. & Jovanovich, S. 1999 Capillary electrophoresis on microchip. Electrophoresis 21, 41-54. (doi:10.1002/(SICI) 1522-2683(20000101)21:1!41::AID-ELPS41O3.0.CO;2-7)
14. Edel, J. B., Lahoud, P., Cass, A. E. & deMello, A. J. 2007 Discrimination between single Escherichia coli cells using time-resolved confocal spectroscopy. J. Phys. Chem. B 111, 1129-1134. (doi:10.1021/jp066530k)
15. Ferrell, J. E. & Xiong, W. 2001 Bistability in cell signaling: how to make continuous processes discontinuous, and reversible processes irreversible. Chaos 11, 227-236. (doi:10.1063/1.1349894)
16. Fiedler, S., Shirley, S., Schnelle, T. & Fuhr, G. 1998 Dielec-trophoretic sorting of particles and cells in a microsystem. Anal. Chem. 70, 1909-1915. (doi:10.1021/ac971063b)
17. Figeys, D. 2002 Adapting arrays and lab-on-a-chip technology for proteomics. Proteomics 2, 373-382. (doi:10.1002/1615-9861(200204)2:4!373::AID- PROT373O3.0.CO;2-I)
18. Fox, M. B., Esveld, D. C., Valero, A., Luttge, R., Mastwijk, H. C., Bartels, P. V., van der Berg, A. & Boom, R. M. 2006 Electroporation of cells in microfluidic devices: a review. Anal. Bioanal. Chem. 385, 474-485. (doi:10.1007/s00216-006-0327-3)
19. Gao, J., Yin, X. F. & Fang, Z. L. 2004 Integration of single cell injection, cell lysis separation and detection of intracellular constituents on a microfluidic chip. Lab Chip 4, 47-52. (doi:10.1039/b310552k)
20. Gowrishankar, T. R., Esser, A. T., Vasilkoski, Z., Smith, K. C. & Weaver, J. C. 2006 Microdosimetry for conventional and supra-electroporation in cells with organelles. Biochem. Biophys. Res. Commun. 341, 1266-1276. (doi:10.1016/j.bbrc.2006.01.094)
21. Haas, K., Sin, W. C., Javaherian, A., Li, Z. & Cline, H. T. 2001 Single-cell electroporation for gene transfer in vivo. Neuron 29, 583-591. (doi:10.1016/S0896-6273(01)00235-5)
22. Heller, M. J. 2002 DNA microarray technology: devices, systems, and applications. Annu. Rev. Biomed. Eng. 4, 129-153. (doi:10.1146/annurev.bioeng.4. 020702.153438)
23. Ho, S. Y., Mittal, G. S. & Cross, J. D. 1997 Effects of high electric field pulses on the activity of selected enzymes. J. Food Eng. 31, 69-84. (doi:10.1016/S0260-8774(96) 00052-0)
24. Huang, Y. & Rubinsky, B. 1999 Micro-electroporation: improving the efficiency and understanding of electrical permeabilization of cells. Biomed. Microdev. 2, 145-150. (doi:10.1023/A:1009901821588)
25. Huang, Y. & Rubinsky, B. 2001 Microfabricated electropora-tion chip for single cell membrane permiabilization. Sens. Actuators A 89, 242-249. (doi:10.1016/S0924-4247(00) 00557-4)
26. Huang, Y., Sekhon, N. S., Borninski, J., Chen, N. & Rubinsky, B. 2003 Instantaneous, quantitative single-cell viability assessment by electrical evaluation of cell membrane integrity with microfabricated devices. Sens. Actuators A 105, 31-39. (doi:10.1016/S0924-4247(03) 00084-0)
27. Huebner, A., Srisa-Art, M., Holt, D., Abell, C., Hollfelder, F., deMello, A. J. & Edel, J. B. 2007 Quantitative detection of protein expression in single cells using droplet micro-fluidics. Chem. Commun. 28, 1218-1220. (doi:10.1039/b618570c)
28. Hutanu, D. & Remcho, V. T. 2007 Aptamers as molecular recognition elements in chromatographic separations. Adv. Chromatogr. 45, 173-196.
29. Knoblich, J. A. 2008 Mechanisms of asymmetric stem cell division. Cell 132, 583-597. (doi:10.1016/j.cell.2008.02.007)
30. Lee, S.-W. & Tai, Y.-C. 1999 A micro cell lysis device. Sens. Actuators A 73, 74-79. (doi:10.1016/S0924-4247(98) 00257-X)
31. Li, P. C. H. & Harrison, D. J. 1997 Transport, manipulation and reaction of biological cells on-chip using electrokinetic effects. Anal. Chem. 69, 1564-1568. (doi:10.1021/ac9606564)
32. Lu, H., Schmidt, M. A. & Jensen, K. F. 2005 A microfluidic electroporation device for cell lysis. Lab Chip 5, 23-29. (doi:10.1039/b406205a)
33. Lundqvist, J. A., Sahlin, F., Aberg, M. A., Strömberg, A., Eriksson, P. S. & Orwar, O. 1998 Altering the biochemical state of individual cultured cells and organelles with ultramicroelectrodes. Proc. Natl Acad. Sci. USA 95, 10 356-10 360. (doi:10.1073/pnas.95.18.10356)
34. Manz, A., Effenhauser, C., Bruggraf, N., Harrison, J., Seiler, K. & Fluri, K. 1994 Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems. J. Micromech. Microeng. 4, 257-265. (doi:10.1088/0960-1317/4/4/010)
35. Markx, G., Huang, Y., Zhou, X. & Pethig, R. 1994 Dielectrophoretic characterization and separation of microorganisms. Microbiology 140, 585-591.
36. McClain, M. A., Culbertson, C. T., Jacobson, S. C., Allbritton, N. L., Sims, C. E. & Ramsey, J. M. 2003 Microfluidic devices for the high-throughput chemical analysis of cells. Anal. Chem. 75, 5646-5655. (doi:10. 1021/ac0346510)
37. Monaghan, P. B., McCarney, K. M., Ricketts, A., Littleford, R. E., Docherty, F., Smith, W. E., Graham, D. & Cooper, J. M. 2007 Bead-based diagnostic assay for chlamydia using nanoparticle-mediated surface-enhanced resonance raman scattering detection within a lab-on-a-chip format. Anal. Chem. 79, 2844-2849. (doi:10.1021/ac061769i)
38. Nolkrantz, K., Farre, C., Brederlau, A., Karlsson, R. I., Brennan, C., Eriksson, P. S., Weber, S. G., Sandberg, M. & Orwar, O. 2001 Electroporation of single cells and tissues with an electrolyte-filled capillary. Anal. Chem. 73, 4469-4477. (doi:10.1021/ac010403x)
39. Nolkrantz, K., Farre, C., Hurtig, K. J., Rylander, P. & Orwar, O. 2002 Functional screening of intracellular proteins in single cells and in patterned cell arrays using electropora-tion. Anal. Chem. 74, 4300-4305. (doi:10.1021/ac025584x)
40. Olofsson, J., Nolkrantz, K., Ryttsen, F., Lambie, B. A., Weber, S. G. & Orwar, O. 2003 Single-cell electroporation. Curr. Opin. Biotechnol. 14, 29-34. (doi:10.1016/S0958-1669(02)00003-4)
41. Prasanna, G. L. & Panda, T. 1997 Electroporation: basic principles, practical considerations and applications in molecular biology. Bioprocess Eng. 16, 261-264. (doi:10. 1007/s004490050319)
42. Rae, J. L. & Levis, R. A. 2002 Single-cell electroporation. Pflugers Arch. 443, 664-670. (doi:10.1007/s00424-001-0753-1)
43. Rusu, C. et al. 2001 Direct integration of micromachined pipettes in a flow channel for single DNA molecule study by optical tweezers. J. Microelectromech. Syst. 10, 238-247. (doi:10.1109/84.925758)
44. Schasfoort, R. B. M. 1999 Field-effect flow control for microfabricated fluidic networks. Science 286, 942-945. (doi:10.1126/science.286.5441.942)
45. Schilling, E., Kamholz, A. & Yager, P. 2002 Cell lysis and protein extraction in a microfluidic device with detection by a fluorogenic enzyme assay. Anal. Chem. 74, 1798-1804. (doi:10.1021/ac015640e)
46. Sia, S. K. & Whitesides, G. M. 2003 Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies. Electrophoresis 24, 3563-3576. (doi:10.1002/elps.200305584)
47. Sigal, A. et al. 2006 Variability and memory of protein levels in human cells. Nature 444, 643-646. (doi:10.1038/nature05316)
48. Sims, C. E. & Allbritton, N. L. 2007 Analysis of single mammalian cells on-chip. Lab Chip 7, 423-440. (doi:10. 1039/b615235j)
49. Suga, M., Goto, A. & Hatakeyama, T. 2006 Control by osmolarity and electric field strength of electro-induced gene transfer and protein release in fission yeast cells. J. Electrostat. 64, 796-801. (doi:10.1016/j.elstat.2006.01. 007)
50. Taylor, M., Belgrader, P., Furman, B., Pourahmadi, F., Kovacs, G. & Northrup, A. 2001 Lysing bacterial spores by sonication through a flexible interface in a microfluidic system. Anal. Chem. 73, 492-496. (doi:10.1021/ac000779v)
51. Templin, M. F., Stoll, D., Schrenk, M., Traub, P. C., Vöhringer, C. F. & Joos, T. O. 2002 Protein microarray technology. Trends Biotechnol. 20, 160-166. (doi:10.1016/S0167-7799(01)01910-2)
52. Tsong, T. Y. & Kinosita, K. 1985 Use of voltage pulses for the pore opening and drug loading and the subsequent resealing of red blood cells. Bibl. Haematol. (Basel) 51, 108-114.
53. Valero, A., Merino, F., Wolbers, F., Luttge, R., Vermes, I., Andersson, S. M. H. & van den Berg, A. 2005 Apoptotic cell death dynamics of HL60 cells studied using a microfluidic cell trap device. Lab Chip 5, 49-55. (doi:10. 1039/b415813j)
54. Wang, X., Yang, J., Huang, Y., Vykoukal, J., Becker, F. & Gascoyne, P. 2000 Cell separation by dielectrophoretic field-flow-fractionation. Anal. Chem. 72, 832-839. (doi:10. 1021/ac990922o)
55. Wilding, P., Kricka, L. J., Cheng, J., Hvichia, G., Shoffner, M. A. & Fortina, P. 1998 Integrated cell isolation and polymerase chain reaction analysis using silicon microfilter chambers. Anal. Biochem. 257, 95-100. (doi:10.1006/abio. 1997.2530)
56. Wong, P. K., Wang, T. H., Deval, J. H. & Ho, C. M. 2004 Electrokinetics in micro devices for biotechnological applications. IEEE/ASME Trans. Mechatron. 9, 366-376. (doi:10.1109/TMECH.2004.828659)
57. Yi, C., Li, C.-W., Ji, S. & Yang, M. 2006 Microfluidics technology for manipulation and analysis of biological cells. Anal. Chim. Acta 560, 1-23. (doi:10.1016/j.aca. 2005.12.037)