Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion

Current Opinion in Nephrology and Hypertension

Volumn 17, Issue 4, 2008, Pages 363-367

  Galitzer, Hillel ^a   Ben Dov, Iddo ^a   Lavi Moshayoff, Vardit ^a   Naveh Many, Tally ^a   Silver, Justin ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Fibroblast growth factor 23; Parathyroid hormone; Phosphate; Vitamin D

Indexed keywords

CALCITRIOL; FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR RECEPTOR 1; KLOTHO PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PARATHYROID HORMONE; PHOSPHATE; BETA GLUCURONIDASE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR;

BONE MINERAL; ENZYME ACTIVATION; GENE EXPRESSION; HOMEOSTASIS; HORMONE RELEASE; IN VITRO STUDY; IN VIVO STUDY; OSTEOCYTE; PHOSPHATURIA; PRIORITY JOURNAL; PROTEIN SECRETION; REVIEW; ANIMAL; BONE; FAMILIAL HYPOPHOSPHATEMIC RICKETS; GENETICS; HUMAN; KIDNEY; PARATHYROID GLAND; PHYSIOLOGY; SECRETION;

ANIMALS; BONE AND BONES; FIBROBLAST GROWTH FACTORS; GLUCURONIDASE; HUMANS; HYPOPHOSPHATEMIA, FAMILIAL; KIDNEY; PARATHYROID GLANDS; PARATHYROID HORMONE; RECEPTORS, FIBROBLAST GROWTH FACTOR;

EID: 55249090183     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e328303e172     Document Type: Review

References (34)

1. White KE, Evans WE, O'Riordan JLH, et al. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 2000; 26:345-348.
2. Shimada T, Mizutani S, Muto T, et al. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S A 2001; 98:6500-6505.
3. Fukagawa M, Nii-Kono T, Kazama JJ. Role of fibroblast growth factor 23 in health and in chronic kidney disease. Curr Opin Nephrol Hypertens 2005; 14:325-329.
4. Fukumoto S, Yamashita T. Fibroblast growth factor-23 is the phosphaturic factor in tumor-induced osteomalacia and may be phosphatonin. Curr Opin Nephrol Hypertens 2002; 11:385-389.
5. Kuro-o M. Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism. Curr Opin Nephrol Hypertens 2006; 15:437-441.
6. Liu S, Gupta A, Quarles LD. Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization. Curr Opin Nephrol Hypertens 2007; 16:329-335.
7. Liu S, Zhou J, Tang W, et al. Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab 2006; 291:E38-E49.
8. Shimada T, Hasegawa H, Yamazaki Y, et al. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 2004; 19:429-435.
9. Jilka RL, Weinstein RS, Bellido T, et al. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J Clin Invest 1999; 104:439-446.
10. Silver J, Naveh-Many T, Kronenberg HM. Parathyroid hormone: molecular biology. In: Bilezikian JB, Raisz LG, Rodan GA, editors. Principles of bone biology, 2nd ed. San Diego: Academic Press; 2002. pp. 407-422.
11. Yano S, Brown EM. The calcium sensing receptor. In: Naveh-Many T, editor. Molecular biology of the parathyroid. New York: Landes Bioscience and Kluwer Academic/Plenum Publishers; 2005. pp. 44-56.
12. Kolek OI, Hines ER, Jones MD, et al. 1alpha, 25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renalgastrointestinal-skeletal axis that controls phosphate transport. Am J Physiol Gastrointest Liver Physiol 2005; 289:G1036-G1042.
13. Liu S, Tang W, Zhou J, et al. Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.J Am Soc Nephrol 2006; 17:1305-1315.
14. Segawa H, Yamanaka S, Ohno Y, et al. Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice. Am J Physiol Renal Physiol 2007; 292:F769-F779.
15. Kurosu H, Ogawa Y, Miyoshi M, et al. Regulation of fibroblast growth factor23 signaling by klotho. J Biol Chem 2006; 281:6120-6123.
16. Urakawa I, Yamazaki Y, Shimada T, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006; 444:770-774.
17. Kuro-o M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390:45-51.
18. Tsujikawa H, Kurotaki Y, Fujimori T, et al. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 2003; 17:2393-2403.
19. Stubbs JR, Liu S, Tang W, et al. Role of hyperphosphatemia and 1, 25-Dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. J Am Soc Nephrol 2007; 18:2116-2124.
20. Liu H, Fergusson MM, Castilho RM, et al. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 2007; 317:803-806.
21. Li SA, Watanabe M, Yamada H, et al. Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct Funct 2004; 29:91-99.
22. Chang Q, Hoefs S, van der Kemp AW, et al. The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 2005; 310: 490-493.
23. Imura A, Iwano A, TohyamaO, et al. Secreted Klotho protein in sera and CSF: implication for posttranslational cleavage in release of Klotho protein from cell membrane. FEBS Lett 2004; 565:143-147.
24. Imura A, Tsuji Y, Murata M, et al. alpha-Klotho as a regulator of calcium homeostasis. Science 2007; 316:1615-1618.
25. Takeshita K, Fujimori T, Kurotaki Y, et al. Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation 2004; 109:1776-1782.
26. Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, et al. The parathyroid is a target organ for FGF23 in rats. J Clin Invest 2007; 117:4003-4008.
27. KrajisnikT, Bjorklund P, Marsell R, et al. Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells. J Endocrinol 2007; 195:125-131.
28. White KE, Jonsson KB, Carn G, et al. The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting. J Clin Endocrinol Metab 2001; 86:497-500.
29. Shimada T, Urakawa I, Yamazaki Y, et al. FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa. Biochem Biophys Res Commun 2004; 314: 409-414.
30. Bai XY, Miao D, Goltzman D, Karaplis AC. The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency. J Biol Chem 2003; 278:9843-9849.
31. Bai X, Miao D, Li J, et al. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinol 2004; 145: 5269-5279.
32. Larsson T, Marsell R, Schipani E, et al. Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia and disturbed phosphate homeostasis. Endocrinology 2004; 145:3087-3094.
33. Martin TJ. A skeleton key to metabolism. Nat Med 2007; 13:1021-1023.
34. Lee NK, Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell 2007; 130:456-469.