Different Na+K+-ATPase signal pathways was involved in the increase of [Ca2+]i induced by strophanthidin in normal and failing isolated guinea pig ventricular myocytes

Acta Pharmacologica Sinica

Volumn 29, Issue 11, 2008, Pages 1313-1318

  Qi, Ya Juan ^a,b   Su, Su Wen ^a   Li, Jun Xia ^a   Li, Ji He ^a   Guo, Fang ^a   Wang, Yong Li ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b NORTH CHINA COAL MEDICAL COLLEGE   (China)

Author keywords

Calcium transient; Chronic heart failure; Contractility; Na+ K+ ATPase; Positive inotropic effect; Signal transduction; Strophanthidin

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM ION; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; STROPHANTHIDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; GUINEA PIG; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE WALL; INOTROPISM; MALE; MUSCLE CELL; NONHUMAN; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; GUINEA PIGS; HEART FAILURE; HEART VENTRICLES; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-EXCHANGING ATPASE; STROPHANTHIDIN;

EID: 55149121002     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00897.x     Document Type: Article

References (21)

1. Blaustein MP, Juhaszova M, Golovina VA. The cellular mechanism of action of cardiotonic steroids: a new hypothesis. Clin Exp Hypertens 1998 20 : 691 703.
2. +-ATPase of strophanthidin at low concentrations. Acta Pharmacol Sin 2003 24 : 1103 7.
3. Yin JX, Wang YL, Li Q, Shang ZL, Su SW, Cheng YP, et al. Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes. Acta Physiol Sin 2002 54 : 385 9.
4. Xie Z. Molecular mechanisms of Na/K-ATPase-mediated signal transduction. Ann NY Acad Sci 2003 986 : 497 503.
5. 2+] i in rat cardiac myocytes. Am J Physiol Heart Circ Physiol 2001 281 : H1899 907.
6. Fitzgerald EM. Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway. J Physiol 2000 527 : 433 4.
7. ATP channels. Mol Cell Biochem 2003 242 : 181 7.
8. Xie Z. Ouabain interaction with cardiac Na/K-ATPase reveals that the enzyme can act as a pump and as a signal transducer. Cell Mol Biol 2001 47 : 383 90.
9. 2+ transport and mechanics in compensated pressure overload hypertrophy and congestive heart failure. Circ Res 1995 77 : 759 64.
10. + pump current in guinea pig ventricular myocytes. J Physiol 1998 509 : 116 28.
11. Ren J, Wold LE. Measurement of cardiac mechanical function in isolated ventricular myocytes from rats and mice by computerized video-based imaging. Biol Proced Online 2001 3 : 43 53.
12. 2+] in single cardiac cells with Fura-2 or indo-1. Cardiovasc Res 1995 29 : 717 26.
13. Ferrandi M, Manunta P. Ouabain-like factor: is this the natriuretic hormone Curr Opin Nephrol Hypertens 2000 9 : 165 71.
14. Ke YS. Endoxin: a major factor regulating cardiovascular system. Acta Pharmacol Sin 2001 22 : 201 9.
15. ATP channel activation in the postanoxic developing heart protects E-C coupling via NO-, ROS-, and PKC-dependent pathways. Am J Physiol Heart Circ Physiol 2005 288 : H1611 9.
16. 2+ transient and contractility in rabbit ventricular myocytes: pharmacological analysis with KB-R7943. Br J Pharmacol 1999 126 : 1785 95.
17. Qi YJ, Li JH, Li SM, Wang YL. The effects of strophanthidin on the contractility and calcium transient of a single normal or failure ventricular myocyte. Chin Pharmacol Bull 2008, 24 : 333 7.
18. Cheng XS, Shimokawa H, Momii H, Oyama J, Fukuyama N, Egashira K, et al. Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo. J Clin Invest 1998 101 : 2207 14.
19. Dhalla AK, Hill MF, Singal PK. Role of oxidative stress in transition of hypertrophy to heart failure. J Am Coll Cardiol 1996 28 : 506 14.
20. Schrier GM, Hess ML. Quantitative identification of superoxide anion as a negative inotropic species. Am J Physiol 1988 255 : 138 43.
21. 2+ concentrations. J Biol Chem 2000 275 : 27 838 44.