메뉴 건너뛰기




Volumn 2, Issue 4, 2008, Pages 479-487

Aerosolized antibiotics in cystic fibrosis: Current and future trends

Author keywords

Aerosolized antibiotic; Cystic fibrosis; Inhaled antibiotic; Inhaled tobramycin nebulization; Pseudomonas aeruginosa

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; AZTREONAM; BETA LACTAM ANTIBIOTIC; CIPROFLOXACIN; COLISTIMETHATE; DORNASE ALFA; GENTAMICIN; LIPOSOME; PIPERACILLIN; POLYMYXIN; TAUROLIDINE; TICARCILLIN; TOBRAMYCIN;

EID: 55149110275     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/17476348.2.4.479     Document Type: Review
Times cited : (21)

References (51)
  • 1
    • 28844487754 scopus 로고    scopus 로고
    • Cystic Fibrosis Foundation, Cystic Fibrosis Foundation, Bethesda, MD, USA
    • Cystic Fibrosis Foundation. Patient Registry: Annual Data Report, 2005. Cystic Fibrosis Foundation, Bethesda, MD, USA (2006).
    • (2006) Patient Registry: Annual Data Report, 2005
  • 2
    • 0025868478 scopus 로고
    • Prevention of chronic Pseudomonas aeruginosa colonisation in cystic fibrosis by early treatment
    • Valerius NH, Koch C, Hoiby N. Prevention of chronic Pseudomonas aeruginosa colonisation in cystic fibrosis by early treatment. Lancet 338(8769), 725-726 (1991).
    • (1991) Lancet , vol.338 , Issue.8769 , pp. 725-726
    • Valerius, N.H.1    Koch, C.2    Hoiby, N.3
  • 3
    • 0030995361 scopus 로고    scopus 로고
    • Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis
    • Frederiksen B, Koch C, Hoiby N. Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis. Pediatr. Pulmonol. 23(5), 330-335 (1997).
    • (1997) Pediatr. Pulmonol , vol.23 , Issue.5 , pp. 330-335
    • Frederiksen, B.1    Koch, C.2    Hoiby, N.3
  • 4
    • 0033531143 scopus 로고    scopus 로고
    • Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group
    • Ramsey BW, Pepe MS, Quan JM et al. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group. N. Engl. J. Med. 340(1), 23-30 (1999).
    • (1999) N. Engl. J. Med , vol.340 , Issue.1 , pp. 23-30
    • Ramsey, B.W.1    Pepe, M.S.2    Quan, J.M.3
  • 5
    • 0034546826 scopus 로고    scopus 로고
    • Technical report: Precautions regarding the use of aerosolized antibiotics. Committee on Infectious Diseases and Committee on Drugs
    • Prober CG, Walson PD, Jones J. Technical report: precautions regarding the use of aerosolized antibiotics. Committee on Infectious Diseases and Committee on Drugs. Pediatrics 106(6), E89 (2000).
    • (2000) Pediatrics , vol.106 , Issue.6
    • Prober, C.G.1    Walson, P.D.2    Jones, J.3
  • 6
    • 0002101312 scopus 로고
    • Celiac Syndrome. IV. Chemotherapy in infections of the respiratory tract associated with cystic fibrosis of the pancreas; observations with penicillin and drugs of the sulfonamide group, with special reference to penicillin aerosol
    • di Sant'Agnese PEA, Andersen D. Celiac Syndrome. IV. Chemotherapy in infections of the respiratory tract associated with cystic fibrosis of the pancreas; observations with penicillin and drugs of the sulfonamide group, with special reference to penicillin aerosol. Am. J. Dis. Child. 72, 17-61 (1946).
    • (1946) Am. J. Dis. Child , vol.72 , pp. 17-61
    • di Sant'Agnese, P.E.A.1    Andersen, D.2
  • 8
    • 0347812929 scopus 로고    scopus 로고
    • Aerosolized antibiotics in cystic fibrosis
    • Sexauer WP, Fiel SB. Aerosolized antibiotics in cystic fibrosis. Semin. Respir. Crit. Care Med. 24(6), 717-726 (2003).
    • (2003) Semin. Respir. Crit. Care Med , vol.24 , Issue.6 , pp. 717-726
    • Sexauer, W.P.1    Fiel, S.B.2
  • 9
    • 0036198938 scopus 로고    scopus 로고
    • The rationale for aerosolized antibiotics
    • Flume P, Klepser ME. The rationale for aerosolized antibiotics. Pharmacotherapy 22(3 Pt 2), S71-S79 (2002).
    • (2002) Pharmacotherapy , vol.22 , Issue.3 PART 2
    • Flume, P.1    Klepser, M.E.2
  • 10
    • 0036736583 scopus 로고    scopus 로고
    • A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis
    • Hodson ME, Gallagher CG, Govan JR. A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis, Eur. Respir. J. 20(3), 658-664 (2002).
    • (2002) Eur. Respir. J , vol.20 , Issue.3 , pp. 658-664
    • Hodson, M.E.1    Gallagher, C.G.2    Govan, J.R.3
  • 11
    • 4544269731 scopus 로고    scopus 로고
    • Treatment with tobramycin solution for inhalation reduces hospitalizations in young CF subjects with mild lung disease
    • Murphy TD, Anbar RD, Lester LA et al. Treatment with tobramycin solution for inhalation reduces hospitalizations in young CF subjects with mild lung disease. Pediatr. Pulmonol. 38(4), 314-320 (2004).
    • (2004) Pediatr. Pulmonol , vol.38 , Issue.4 , pp. 314-320
    • Murphy, T.D.1    Anbar, R.D.2    Lester, L.A.3
  • 12
    • 0142043977 scopus 로고    scopus 로고
    • Pathophysiology and management of pulmonary infections in cystic fibrosis
    • Gibson RL, Burns JL, Ramsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am. J. Respir. Grit. Care Med. 168(8), 918-951 (2003).
    • (2003) Am. J. Respir. Grit. Care Med , vol.168 , Issue.8 , pp. 918-951
    • Gibson, R.L.1    Burns, J.L.2    Ramsey, B.W.3
  • 13
    • 33750302487 scopus 로고    scopus 로고
    • Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis
    • Ratjen F. Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis. Curr. Opin. Pulm. Med. 12(6), 428-432 (2006).
    • (2006) Curr. Opin. Pulm. Med , vol.12 , Issue.6 , pp. 428-432
    • Ratjen, F.1
  • 14
    • 23444434606 scopus 로고    scopus 로고
    • Early eradication therapy against Pseudomonas aeruginosa in cystic fibrosis patients
    • Taccetti G, Campana S, Festini F, Mascherini M, Doring G. Early eradication therapy against Pseudomonas aeruginosa in cystic fibrosis patients. Eur. Respir. J. 26(3), 458-461 (2005).
    • (2005) Eur. Respir. J , vol.26 , Issue.3 , pp. 458-461
    • Taccetti, G.1    Campana, S.2    Festini, F.3    Mascherini, M.4    Doring, G.5
  • 15
    • 0842281535 scopus 로고    scopus 로고
    • Recombinant OprF-OprI as a vaccine against Pseudomonas aeruginosa infections
    • Baumann U, Mansouri E, von Specht BU. Recombinant OprF-OprI as a vaccine against Pseudomonas aeruginosa infections. Vaccine 22(7), 840-847 (2004).
    • (2004) Vaccine , vol.22 , Issue.7 , pp. 840-847
    • Baumann, U.1    Mansouri, E.2    von Specht, B.U.3
  • 16
    • 0032968947 scopus 로고    scopus 로고
    • Effect of chronic intermittent administration of inhaled tobramycin on respiratory microbial flora in patients with cystic fibrosis
    • Burns JL, Van Dalfsen JM, Shawar RM et al. Effect of chronic intermittent administration of inhaled tobramycin on respiratory microbial flora in patients with cystic fibrosis. J. Infect. Dis. 179(5), 1190-1196 (1999).
    • (1999) J. Infect. Dis , vol.179 , Issue.5 , pp. 1190-1196
    • Burns, J.L.1    Van Dalfsen, J.M.2    Shawar, R.M.3
  • 17
    • 0036167851 scopus 로고    scopus 로고
    • Effects of reduced mucus oxygen concentration in airway Pseudamonas infections of cystic fibrosis patients
    • Worlitzsch D, Tartan R, Ulrich M et al. Effects of reduced mucus oxygen concentration in airway Pseudamonas infections of cystic fibrosis patients. J. Clin. Invest. 109(3), 317-325 (2002).
    • (2002) J. Clin. Invest , vol.109 , Issue.3 , pp. 317-325
    • Worlitzsch, D.1    Tartan, R.2    Ulrich, M.3
  • 18
    • 0346505482 scopus 로고    scopus 로고
    • New concepts of the pathogenesis of cystic fibrosis lung disease
    • Boucher RC. New concepts of the pathogenesis of cystic fibrosis lung disease. Eur. Respir. J. 23(1), 146-158 (2004).
    • (2004) Eur. Respir. J , vol.23 , Issue.1 , pp. 146-158
    • Boucher, R.C.1
  • 19
    • 0034828531 scopus 로고    scopus 로고
    • Formulation of aerosolized therapeutics
    • Kuhn RJ. Formulation of aerosolized therapeutics. Chest 120(3 Suppl.), S94-S98 (2001).
    • (2001) Chest , vol.120 , Issue.3 SUPPL.
    • Kuhn, R.J.1
  • 20
    • 0036195602 scopus 로고    scopus 로고
    • Pharmaceutical considerations in aerosol drug delivery
    • Kuhn RJ. Pharmaceutical considerations in aerosol drug delivery. Pharmacotherapy 22(3 Pt 2), S80-S85 (2002).
    • (2002) Pharmacotherapy , vol.22 , Issue.3 PART 2
    • Kuhn, R.J.1
  • 21
    • 0021996644 scopus 로고
    • Nebulised colomycin for early, Pseudomonas colonisation in cystic fibrosis
    • Littlewood JM, Miller MG, Ghoneim AT, Ramsden CH. Nebulised colomycin for early, Pseudomonas colonisation in cystic fibrosis. Lancet 1 (8433), 865 (1985).
    • (1985) Lancet , vol.1 , Issue.8433 , pp. 865
    • Littlewood, J.M.1    Miller, M.G.2    Ghoneim, A.T.3    Ramsden, C.H.4
  • 22
    • 0345534831 scopus 로고    scopus 로고
    • Dry powder versus intravenous and nebulized gentanricin in cystic fibrosis and bronchiectasis. A pilot study
    • Crowther Labiris NR, Holbrook AM, Chrystyn H, Macleod SM, Newhouse MT. Dry powder versus intravenous and nebulized gentanricin in cystic fibrosis and bronchiectasis. A pilot study. Am. J. Respir. Crit. Care Med. 160(5 Pt 1), 1711-1716 (1999).
    • (1999) Am. J. Respir. Crit. Care Med , vol.160 , Issue.5 PART 1 , pp. 1711-1716
    • Crowther Labiris, N.R.1    Holbrook, A.M.2    Chrystyn, H.3    Macleod, S.M.4    Newhouse, M.T.5
  • 23
    • 0023202934 scopus 로고
    • Efficacy of inhaled amikacin as adjunct to intravenous combination therapy (ceftazidime and amikacin) in cystic fibrosis
    • Schaad UB, Wedgwood-Krucko J, Suter S, Kraemer R. Efficacy of inhaled amikacin as adjunct to intravenous combination therapy (ceftazidime and amikacin) in cystic fibrosis. J. Pediatr. 111(4), 599-605 (1987).
    • (1987) J. Pediatr , vol.111 , Issue.4 , pp. 599-605
    • Schaad, U.B.1    Wedgwood-Krucko, J.2    Suter, S.3    Kraemer, R.4
  • 24
    • 33745686502 scopus 로고    scopus 로고
    • Microbiology, safety, and pharmacokinetics of aztreonam lysinate for inhalation in patients with cystic fibrosis
    • Gibson RL, Retsch-Bogart GZ, Oermann C et al. Microbiology, safety, and pharmacokinetics of aztreonam lysinate for inhalation in patients with cystic fibrosis. Pediatr. Pulmonol. 41(7), 656-665 (2006).
    • (2006) Pediatr. Pulmonol , vol.41 , Issue.7 , pp. 656-665
    • Gibson, R.L.1    Retsch-Bogart, G.Z.2    Oermann, C.3
  • 25
    • 0036223381 scopus 로고    scopus 로고
    • A randomized double-blinded placebo-controlled crossover trial of nebulized taurolidine in adult cystic fibrosis patients infected with Burkholderia cepacia
    • Ledson MJ, Gallagher MJ, Robinson M et al. A randomized double-blinded placebo-controlled crossover trial of nebulized taurolidine in adult cystic fibrosis patients infected with Burkholderia cepacia. J. Aerosol. Med. 15(1), 51-57 (2002).
    • (2002) J. Aerosol. Med , vol.15 , Issue.1 , pp. 51-57
    • Ledson, M.J.1    Gallagher, M.J.2    Robinson, M.3
  • 26
    • 0031730360 scopus 로고    scopus 로고
    • Review of pharmacokinetics and pharmacodynamics of antimicrobial agents
    • Estes L. Review of pharmacokinetics and pharmacodynamics of antimicrobial agents. Mayo Clin. Proc. 73(11), 1114-1122 (1998).
    • (1998) Mayo Clin. Proc , vol.73 , Issue.11 , pp. 1114-1122
    • Estes, L.1
  • 27
    • 0031037472 scopus 로고    scopus 로고
    • Pharmacokinetics of aerosolized tobramycin in adult patients with cystic fibrosis
    • Touw DJ, Jacobs FA, Brimicombe RW et al. Pharmacokinetics of aerosolized tobramycin in adult patients with cystic fibrosis. Antimicrob. Agents Chemother. 41(1), 184-187 (1997).
    • (1997) Antimicrob. Agents Chemother , vol.41 , Issue.1 , pp. 184-187
    • Touw, D.J.1    Jacobs, F.A.2    Brimicombe, R.W.3
  • 28
    • 0036382644 scopus 로고    scopus 로고
    • Evaluation of bronchial constriction in children with cystic fibrosis after inhaling two different preparations of tobramycin
    • Alothman GA, Alsaadi MM, Ho BL et al. Evaluation of bronchial constriction in children with cystic fibrosis after inhaling two different preparations of tobramycin. Chest 122(3), 930-934 (2002).
    • (2002) Chest , vol.122 , Issue.3 , pp. 930-934
    • Alothman, G.A.1    Alsaadi, M.M.2    Ho, B.L.3
  • 29
    • 18844452358 scopus 로고    scopus 로고
    • Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: An update
    • Mouton JW, Dudley MN, Cars O, Derendorf H, Drusano GL. Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update. J. Antimicrob. Chemother. 55(5), 601-607 (2005).
    • (2005) J. Antimicrob. Chemother , vol.55 , Issue.5 , pp. 601-607
    • Mouton, J.W.1    Dudley, M.N.2    Cars, O.3    Derendorf, H.4    Drusano, G.L.5
  • 30
    • 0034835277 scopus 로고    scopus 로고
    • Microbiological and immunologic considerations with aerosolized drug delivery
    • LiPuma JJ. Microbiological and immunologic considerations with aerosolized drug delivery. Chest 120(3 Suppl.), S118-S123 (2001).
    • (2001) Chest , vol.120 , Issue.3 SUPPL.
    • LiPuma, J.J.1
  • 31
    • 33847777944 scopus 로고    scopus 로고
    • Westerman EM, Heijerman HG, Frijlink HW. Dry powder inhalation versus wet nebulisation delivery of antibiotics in cystic fibrosis patients. Expert Opin. Drug Deliv. 4(2), 91-94 (2007).
    • Westerman EM, Heijerman HG, Frijlink HW. Dry powder inhalation versus wet nebulisation delivery of antibiotics in cystic fibrosis patients. Expert Opin. Drug Deliv. 4(2), 91-94 (2007).
  • 32
    • 0030999183 scopus 로고    scopus 로고
    • A comparison of peak sputum tobramycin concentration in patients with cystic fibrosis using jet and ultrasonic nebulizer systems. Aerosolized Tobramycin Study Group
    • Eisenberg J, Pepe M, Williams-Warren J et al. A comparison of peak sputum tobramycin concentration in patients with cystic fibrosis using jet and ultrasonic nebulizer systems. Aerosolized Tobramycin Study Group. Chest 111(4), 955-962 (1997).
    • (1997) Chest , vol.111 , Issue.4 , pp. 955-962
    • Eisenberg, J.1    Pepe, M.2    Williams-Warren, J.3
  • 33
    • 0022353251 scopus 로고
    • Aminoglycoside penetration, inactivation, and efficacy in cystic fibrosis sputum
    • Mendelman PM, Smith AL, Levy J et al. Aminoglycoside penetration, inactivation, and efficacy in cystic fibrosis sputum. Am. Rev. Respir. Dis. 132(4), 761-765 (1985).
    • (1985) Am. Rev. Respir. Dis , vol.132 , Issue.4 , pp. 761-765
    • Mendelman, P.M.1    Smith, A.L.2    Levy, J.3
  • 34
    • 0028343935 scopus 로고
    • Absolute bioavailability and absorption characteristics of aerosolized tobramycin in adults with cystic fibrosis
    • Cooney GF, Lum BL, Tomaselli M, Fiel SB. Absolute bioavailability and absorption characteristics of aerosolized tobramycin in adults with cystic fibrosis. J. Clin. Pharmacol. 34(3), 255-259 (1994).
    • (1994) J. Clin. Pharmacol , vol.34 , Issue.3 , pp. 255-259
    • Cooney, G.F.1    Lum, B.L.2    Tomaselli, M.3    Fiel, S.B.4
  • 35
    • 40449099605 scopus 로고    scopus 로고
    • Inhalation of tobramycin in patients with cystic fibrosis: comparison of two methods, 58Suppl. 5 Pt 1
    • Dopfer R, Brand P, Mullinger B et al. Inhalation of tobramycin in patients with cystic fibrosis: comparison of two methods. J. Physiol. Pharmacol. 58(Suppl. 5 Pt 1), 141-154 (2007).
    • (2007) J. Physiol. Pharmacol , pp. 141-154
    • Dopfer, R.1    Brand, P.2    Mullinger, B.3
  • 36
    • 34247193128 scopus 로고    scopus 로고
    • Novel tobramycin inhalation powder in cystic fibrosis subjects: Pharmacokinetics and safety
    • Geller DE, Konstan MW, Smith J, Noonberg SB, Conrad C. Novel tobramycin inhalation powder in cystic fibrosis subjects: pharmacokinetics and safety. Pediatr. Pulmonol. 42(4), 307-313 (2007).
    • (2007) Pediatr. Pulmonol , vol.42 , Issue.4 , pp. 307-313
    • Geller, D.E.1    Konstan, M.W.2    Smith, J.3    Noonberg, S.B.4    Conrad, C.5
  • 37
    • 0037998152 scopus 로고    scopus 로고
    • Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia
    • Fok TF, Monkman S, Dolovich M et al. Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. Pediatr Pulmonol. 21(5), 301-309 (1996).
    • (1996) Pediatr Pulmonol , vol.21 , Issue.5 , pp. 301-309
    • Fok, T.F.1    Monkman, S.2    Dolovich, M.3
  • 38
    • 30344479127 scopus 로고    scopus 로고
    • Hagerman JK, Hancock KE, Klepser ME. Aerosolised antibiotics: a critical appraisal of their use. Expert Opin. Drug Deliv. 3(1), 71-86 (2006).
    • Hagerman JK, Hancock KE, Klepser ME. Aerosolised antibiotics: a critical appraisal of their use. Expert Opin. Drug Deliv. 3(1), 71-86 (2006).
  • 39
    • 38349058630 scopus 로고    scopus 로고
    • A Phase 2 study of aztreonam lysine for inhalation to treat patients with cystic fibrosis and Pseudomonas aeruginosa infection
    • Retsch-Bogart GZ, Burns JL, Otto KL et al. A Phase 2 study of aztreonam lysine for inhalation to treat patients with cystic fibrosis and Pseudomonas aeruginosa infection. Pediatr. Pulmonol. 43(1), 47-58 (2008).
    • (2008) Pediatr. Pulmonol , vol.43 , Issue.1 , pp. 47-58
    • Retsch-Bogart, G.Z.1    Burns, J.L.2    Otto, K.L.3
  • 40
    • 0035985889 scopus 로고    scopus 로고
    • Dry powder inhalation of antibiotics in cystic fibrosis therapy: Part 2. Inhalation of a novel colistin dry powder formulation: a feasibility study in healthy volunteers and patients
    • Le Brun PP, de Boer AH, Mannes GP et al. Dry powder inhalation of antibiotics in cystic fibrosis therapy: part 2. Inhalation of a novel colistin dry powder formulation: a feasibility study in healthy volunteers and patients. Eur. J. Pharm. Biopharm. 54(1), 25-32 (2002).
    • (2002) Eur. J. Pharm. Biopharm , vol.54 , Issue.1 , pp. 25-32
    • Le Brun, P.P.1    de Boer, A.H.2    Mannes, G.P.3
  • 41
    • 41149105955 scopus 로고    scopus 로고
    • Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections
    • Meers P, Neville M, Malinin V et al. Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections. J. Antimicrob. Chemother. 61(4), 859-868 (2008).
    • (2008) J. Antimicrob. Chemother , vol.61 , Issue.4 , pp. 859-868
    • Meers, P.1    Neville, M.2    Malinin, V.3
  • 42
    • 34548758436 scopus 로고    scopus 로고
    • Bactericidal efficacy of liposomal aminoglycosides against Burkholderia cenocepacia
    • Halwani M, Mugabe C, Azghani AO et al. Bactericidal efficacy of liposomal aminoglycosides against Burkholderia cenocepacia. J. Antimicrob. Chemother. 60(4), 760-769 (2007).
    • (2007) J. Antimicrob. Chemother , vol.60 , Issue.4 , pp. 760-769
    • Halwani, M.1    Mugabe, C.2    Azghani, A.O.3
  • 43
    • 23144466480 scopus 로고    scopus 로고
    • Liposomal amikacin dry powder inhaler: Effect of fines on in vitro performance
    • Shah SP, Misra A. Liposomal amikacin dry powder inhaler: effect of fines on in vitro performance. AAPS PharmSciTech. 5(4), e65 (2004).
    • (2004) AAPS PharmSciTech , vol.5 , Issue.4
    • Shah, S.P.1    Misra, A.2
  • 44
    • 29244461477 scopus 로고    scopus 로고
    • Preparation and characterization of dehydration-rehydration vesicles loaded with aminoglycoside and macrolide antibiotics
    • Mugabe C, Azghani AO, Omri A. Preparation and characterization of dehydration-rehydration vesicles loaded with aminoglycoside and macrolide antibiotics. Int. J. Pharm. 307(2), 244-250 (2006).
    • (2006) Int. J. Pharm , vol.307 , Issue.2 , pp. 244-250
    • Mugabe, C.1    Azghani, A.O.2    Omri, A.3
  • 45
    • 0028129568 scopus 로고
    • Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group
    • Fuchs HJ, Borowitz DS, Christiansen DH et al. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group. N. Engl. J. Med. 331(10), 637-642 (1994).
    • (1994) N. Engl. J. Med , vol.331 , Issue.10 , pp. 637-642
    • Fuchs, H.J.1    Borowitz, D.S.2    Christiansen, D.H.3
  • 46
    • 0034785372 scopus 로고    scopus 로고
    • Genotypic characterization of Pseudomonas aeruginosa strains recovered from patients with cystic fibrosis after initial and subsequent colonization
    • Munck A, Bonacorsi S, Mariani-Kurkdjian P et al. Genotypic characterization of Pseudomonas aeruginosa strains recovered from patients with cystic fibrosis after initial and subsequent colonization. Pediatr. Pulmonol. 32(4), 288-292 (2001).
    • (2001) Pediatr. Pulmonol , vol.32 , Issue.4 , pp. 288-292
    • Munck, A.1    Bonacorsi, S.2    Mariani-Kurkdjian, P.3
  • 47
    • 21244451543 scopus 로고    scopus 로고
    • Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing
    • Foweraker JE, Laughton CR, Brown DF, Bilton D. Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing. J. Antimicrob. Chemother. 55(6), 921-927 (2005).
    • (2005) J. Antimicrob. Chemother , vol.55 , Issue.6 , pp. 921-927
    • Foweraker, J.E.1    Laughton, C.R.2    Brown, D.F.3    Bilton, D.4
  • 48
    • 0037541096 scopus 로고    scopus 로고
    • Susceptibility testing of Pseudamonas aeruginosa isolates and clinical response to parenteral antibiotic administration: Lack of association in cystic fibrosis
    • Smith AL, Fiel SB, Mayer-Hamblett N, Ramsey B, Burns JL. Susceptibility testing of Pseudamonas aeruginosa isolates and clinical response to parenteral antibiotic administration: lack of association in cystic fibrosis. Chest 123(5), 1495-1502 (2003).
    • (2003) Chest , vol.123 , Issue.5 , pp. 1495-1502
    • Smith, A.L.1    Fiel, S.B.2    Mayer-Hamblett, N.3    Ramsey, B.4    Burns, J.L.5
  • 49
    • 23444457294 scopus 로고    scopus 로고
    • Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: A randomised, double-blind, controlled clinical trial
    • Aaron SD, Vandemheen KL, Ferris W et al. Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: a randomised, double-blind, controlled clinical trial. Lancet 366(9484), 463-471 (2005).
    • (2005) Lancet , vol.366 , Issue.9484 , pp. 463-471
    • Aaron, S.D.1    Vandemheen, K.L.2    Ferris, W.3
  • 50
    • 0034834836 scopus 로고    scopus 로고
    • Administration of aerosolized antibiotics in cystic fibrosis patients
    • Moss RB. Administration of aerosolized antibiotics in cystic fibrosis patients. Chest 120(3 Suppl.), S107-S113 (2001).
    • (2001) Chest , vol.120 , Issue.3 SUPPL.
    • Moss, R.B.1
  • 51
    • 0036890364 scopus 로고    scopus 로고
    • Insights into cystic fibrosis microbiology from the European tobramycin trial in cystic fibrosis
    • Govan JR. Insights into cystic fibrosis microbiology from the European tobramycin trial in cystic fibrosis. J. Cyst. Fibros. 1(Suppl. 2), 203-208 (2002).
    • (2002) J. Cyst. Fibros , vol.1 , Issue.SUPPL. 2 , pp. 203-208
    • Govan, J.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.