Proteins and satiety: Implications for weight management

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 11, Issue 6, 2008, Pages 747-751

  Soenen, Stijn ^a,b   Westerterp Plantenga, Margriet S ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

Author keywords

Adverse effects; Amino acids; Energy expenditure; Gut peptides; Timing

Indexed keywords

AMINO ACID; HORMONE; PROTEIN; SULFUR AMINO ACID;

ADVERSE OUTCOME; BODY MASS; CALORIC INTAKE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; ENZYME SUBSTRATE; FOOD TEXTURE; HUMAN; KIDNEY INJURY; LONG TERM EXPOSURE; MACRONUTRIENT; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OXIDATION; PHYSICAL CAPACITY; PROTEIN DIET; PROTEIN INTAKE; PSYCHOPHYSIOLOGY; REVIEW; SATIETY; TOTAL QUALITY MANAGEMENT; WEIGHT CONTROL; WEIGHT REDUCTION;

DIET, CARBOHYDRATE-RESTRICTED; DIETARY PROTEINS; ENERGY INTAKE; ENERGY METABOLISM; HUMANS; KIDNEY DISEASES; OBESITY; SATIETY RESPONSE; WEIGHT LOSS;

EID: 55149085649     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e328311a8c4     Document Type: Review

References (31)

1. Seidell JC. Obesity in Europe. Obes Res 1995; 3 (Suppl 2):89s-93s.
2. Pi-Sunyer FX. Medical hazards of obesity. Ann Intern Med 1993; 119 (7 Pt 2): 655-660.
3. Westerterp-Plantenga MS, Luscombe-Marsh N, Lejeune MPGM, et al. Dietary protein, metabolism, and body-weight regulation: dose-response effects, Int J Obes 2006; 30:S16-S23.
4. Veldhorst M, Smeets A, Soenen S, et al. Protein-induced satiety: effects and mechanisms of different proteins. Physiol Behav 2008; 94:300-307.
5. Smeets AJ, Soenen S, Luscombe-Marsh ND, et al. Energy expenditure, satiety, and plasma ghrelin, glucagon-like peptide 1, and peptide tyrosine-tyrosine concentrations following a single high-protein lunch. J Nutr 2008; 138:698-702. It was shown clearly that a GLP-1 response is primarily nutrient related, and only secondarily satiety related, as the high-protein lunch evoked the higher satiety response but not a higher GLP-1 response, whereas the adequate protein but high-carbohydrate lunch evoked the lower satiety response but higher GLP-1 response.
6. Westerterp-Plantenga MS, Lejeune MP, Nijs I, et al. High protein intake sustains weight maintenance after body weight loss in humans, Int J Obes Relat Metab Disord 2004; 28:57-64.
7. Lejeune MP, Kovacs EM, Westerterp-Plantenga MS. Additional protein intake limits weight regain after weight loss in humans. Br J Nutr 2005; 93:281-289.
8. Lejeune MP, Westerterp KR, Adam TC, et al. Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber. Am J Clin Nutr 2006; 83:89-94.
9. Luhovyy BL, Akhavan T, Anderson GH. Whey proteins in the regulation of food intake and satiety. J Am Coll Nutr 2007; 26:704S-712S.
10. Veldhorst MAB, Nieuwenhuizen A, Hochstenbach-Waelen A, et al. Effects of high and normal whey with or without GMP-protein breakfasts on amino acid, satiety, 'satiety' hormone responses and energy intake. Appetite 2007; 49:336. It is shown that when offering test meals, taking timing into account is crucial. GMP as a whey-fraction reduced energy intake at a sensitive moment in time, coinciding with increased concentrations of certain amino acids, for example, serine, threonine, alanine, and isoleucine, dominating effects from total whey protein concentrations.
11. Veldhorst MAB, Nieuwenhuizen A, Hochstenbach-Waelen A, et al. Comparison of the effects of high and normal casein-breakfasts on satiety, 'satiety' hormones, plasma amino acids and subsequent energy intake. Br J Nutr 2008; 18:1-9.
12. Nieuwenhuizen AG, Hochstenbach-Waelen A, Veldhorst MAB, et al. Effects of alpha-lactalbumin and gelatin with or without tryptophan protein break-fasts on hunger, 'satiety' hormones, and protein kinetics, Int J Obes 2008; 32:30. Trp, either as part of alpha-lactalbumin or added to gelatin did, contrarily to what is expected, not explain differences in satiety between alpha-lactalbumin (showing more hunger suppression) and gelatin, or gelatin with added Trp (no difference between the latter two).
13. Koren MS, Purnell JQ, Breen PA, et al. Changes in plasma amino acid levels do not predict satiety and weight loss on diets with modified macronutrient composition. Ann Nutr Metab 2007; 51:182-187. Carbohydrate or protein intake increases satiety and leads to significant weight loss that was contrarily to the expectation, independent of an increase in plasma concentration of Trp or the Trp/LNAA ratio.
14. Veldhorst MAB, Nieuwenhuizen A, Hochstenbach-Waelen A, et al. Effects of casein, soy, whey with or without GMP, alphalactalbumin, or gelatin with or without tryptophan-protein breakfasts on energy intake, Int J Obes 2008; 32:142. Incomplete proteins, at 10 and at 25 energy percentage from one type of protein consumed with a custard breakfast, reduced energy intake at lunch with about 20% compared with complete proteins.
15. Diepvens K, Haberer D, Westerterp-Plantenga MS. Different proteins and biopeptides differently affect satiety and anorexigenic/orexigenic hormones in healthy humans, Int J Obes 2008; 32:10-18. Effects on relevant hormones were primarily nutrient related. CCK and GLP-1 concentrations were relatively more increased by milk protein, whereas PYY concentrations were relatively more elevated and ghrelin concentrations more reduced by PPH and whey protein, and did not, as often is assumed, correspond mathematically to satiety.
16. Batterham RL, Heffron H, Kapoor S, et al. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab 2006; 4:223-233.
17. Pichon L, Potier M, Tome D, et al. High protein diets containing different milk protein fractions differently influence food intake and adiposity in rat. Br J Nutr 2008; 99:739-748. Effects of different fractions of whey proteins; milk, whey and β-lac in rats were compared. First case that shows that food intake and body-weight gain were significantly lower in rats fed with the β-lac-containing diet, which was unrelated to palatability.
18. Bowen J, Noakes M, Clifton PM. Energy intake, ghrelin, and cholecystokinin after different carbohydrate and protein preloads in overweight men. J Clin Endocrinol Metab 2006; 91:1477-1483.
19. Bowen J, Noakes M, Clifton PM. Appetite regulatory hormone responses to various dietary proteins differ by body mass index status despite similar reductions in ad libitum energy intake. J Clin Endocrinol Metab 2006;91:2913-2919.
20. Burton-Freeman BM. Glycomacropeptide (GMP) is not critical to whey-induced satiety, but may have a unique role in energy intake regulation through cholecystokinin (CCK). Physiol Behav 2008; 93:379-387. No effect from GMP; CCK release coincided with magnitude of satiety ratings.
21. Bertenshaw EJ, Lluch A, Yeomans MR. Satiating effects of protein but not carbohydrate consumed in a between meal beverage context. Physiol Behav 2008; 93:427-436. Satiety differences between drinks are hardly shown. Surprisingly here, protein-induced satiety was shown with drinks.
22. Harper A, James A, Rint A, et al. Increased satiety after intake of a chocolate milk drink compared with a carbonated beverage, but no difference in subsequent ad libitum lunch intake. Br J Nutr 2007; 97:579-583. Satiety differences between drinks are hardly shown. Surprisingly here, protein-induced satiety was shown with drinks.
23. Soenen S, Westerterp-Plantenga MS. No differences in satiety or energy intake after high-fructose com syrup, sucrose, or milk preloads. Am J Clin Nutr 2007; 86:1586-1594. European study in which lack of satiety differences was shown using protein, sucrose, and fructose-containing drinks, underscored with a large range of metabolic parameters.
24. Bellissimo N, Desantadina MV, Pencharz PB, et al. A comparison of short-term appetite and energy intakes in normal weight and obese boys following glucose and whey-protein drinks, Int J Obes (Lond) 2008; 32:362-371. Satiety differences between drinks are hardly shown. Surprisingly here, protein-induced satiety was shown with drinks.
25. Mellinkoff SM. Relationship between serum amino acid concentration and fluctuations in appetite. J Appl Physiol 1956; 8:535-538.
26. Faipoux R, Tome D, Gougis S, et al. Proteins activate satiety-related neuronal pathways in the brainstem and hypothalamus of rats. J Nutr 2008; 138:1172-1178. This is the first demonstration that in the nucleus of the solitary tract (NTS), the acute or chronic intake of high-protein meals led to increased activation of the noradrenergic/adrenergic neurons involved in cholecystokinin-induced satiety. In the arcuate nucleus of the hypothalamus, the melanocortin pathway was also more strongly activated after the acute or chronic intake of high-protein meals.
27. Weigle DS, Breen PA, Matthys CC, et al. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr 2005; 82:41-48.
28. Frassetto LA, Morris RC Jr, Sebastian A. A practical approach to the balance between acid production and renal acid excretion in humans. J Nephrol 2006; 19 (Suppl 9):S33-S40.
29. Hoy WE, Hughson MD, Bertram JF, et al. Nephron number, hypertension, renal disease, and renal failure. J Am Soc Nephrol 2005; 16:2557-2564.
30. Praga M. Synergy of low nephron number and obesity: a new focus on hyperfiltration nephropathy. Nephrol Dial Transplant 2005; 20:2594-2597.
31. Bagby SP. Maternal nutrition, low nephron number, and hypertension in later life: pathways of nutritional programming. J Nutr 2007; 137:1066-1072.