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Volumn 33, Issue 1, 2009, Pages 115-122

Bortezomib inhibits maturation and function of osteoclasts from PBMCs of patients with multiple myeloma by downregulating TRAF6

Author keywords

Bortezomib; Multiple myeloma; Osteoclast; TRAF6 (tumor necrosis factor receptor associated factor 6)

Indexed keywords

BORTEZOMIB; COLONY STIMULATING FACTOR 1; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

EID: 55049087150     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2008.07.028     Document Type: Article
Times cited : (51)

References (29)
  • 1
    • 1542330894 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • Roodman G.D. Pathogenesis of myeloma bone disease. Blood Cells Mol Dis 32 (2004) 290-292
    • (2004) Blood Cells Mol Dis , vol.32 , pp. 290-292
    • Roodman, G.D.1
  • 3
    • 33845193025 scopus 로고    scopus 로고
    • Myeloma bone disease: pathogenetic mechanisms and clinical assessment
    • Silvestris F., Lombardi L., De Matteo M., Bruno A., and Dammacco F. Myeloma bone disease: pathogenetic mechanisms and clinical assessment. Leuk Res 31 (2007) 129-138
    • (2007) Leuk Res , vol.31 , pp. 129-138
    • Silvestris, F.1    Lombardi, L.2    De Matteo, M.3    Bruno, A.4    Dammacco, F.5
  • 4
    • 33644558753 scopus 로고    scopus 로고
    • Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model
    • Yaccoby S., Wezeman M.J., Zangari M., et al. Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica 91 (2006) 192-199
    • (2006) Haematologica , vol.91 , pp. 192-199
    • Yaccoby, S.1    Wezeman, M.J.2    Zangari, M.3
  • 5
    • 4944230728 scopus 로고    scopus 로고
    • Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion
    • Abe M., Hiura K., Wilde J., et al. Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion. Blood 104 (2004) 2484-2491
    • (2004) Blood , vol.104 , pp. 2484-2491
    • Abe, M.1    Hiura, K.2    Wilde, J.3
  • 6
    • 4143082697 scopus 로고    scopus 로고
    • New insight in the mechanism of osteoclast activation and formation in multiple myeloma: focus on the receptor activator of NF-kappaB ligand (RANKL)
    • Giuliani N., Colla S., and Rizzoli V. New insight in the mechanism of osteoclast activation and formation in multiple myeloma: focus on the receptor activator of NF-kappaB ligand (RANKL). Exp Hematol 32 (2004) 685-691
    • (2004) Exp Hematol , vol.32 , pp. 685-691
    • Giuliani, N.1    Colla, S.2    Rizzoli, V.3
  • 7
    • 0037097587 scopus 로고    scopus 로고
    • Immunocytochemistry reveals RANKL expression of myeloma cells
    • [author reply 4647]
    • Sezer O., Heider U., Jakob C., et al. Immunocytochemistry reveals RANKL expression of myeloma cells. Blood 99 (2002) 4646-4647 [author reply 4647]
    • (2002) Blood , vol.99 , pp. 4646-4647
    • Sezer, O.1    Heider, U.2    Jakob, C.3
  • 8
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index
    • Terpos E., Szydlo R., Apperley J.F., et al. Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index. Blood 102 (2003) 1064-1069
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3
  • 9
    • 16644371934 scopus 로고    scopus 로고
    • Human osteoclast culture from peripheral blood monocytes: phenotypic characterization and quantitation of resorption
    • Buckley K.A., Chan B.Y., Fraser W.D., and Gallagher J.A. Human osteoclast culture from peripheral blood monocytes: phenotypic characterization and quantitation of resorption. Methods Mol Med 107 (2005) 55-68
    • (2005) Methods Mol Med , vol.107 , pp. 55-68
    • Buckley, K.A.1    Chan, B.Y.2    Fraser, W.D.3    Gallagher, J.A.4
  • 10
    • 0033561039 scopus 로고    scopus 로고
    • TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
    • Lomaga M.A., Yeh W.C., Sarosi I., et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 13 (1999) 1015-1024
    • (1999) Genes Dev , vol.13 , pp. 1015-1024
    • Lomaga, M.A.1    Yeh, W.C.2    Sarosi, I.3
  • 11
    • 6544270833 scopus 로고    scopus 로고
    • Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
    • Naito A., Azuma S., Tanaka S., et al. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4 (1999) 353-362
    • (1999) Genes Cells , vol.4 , pp. 353-362
    • Naito, A.1    Azuma, S.2    Tanaka, S.3
  • 12
    • 0036150184 scopus 로고    scopus 로고
    • Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6
    • Mizukami J., Takaesu G., Akatsuka H., et al. Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol 22 (2002) 992-1000
    • (2002) Mol Cell Biol , vol.22 , pp. 992-1000
    • Mizukami, J.1    Takaesu, G.2    Akatsuka, H.3
  • 13
    • 13044316551 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    • Hsu H., Lacey D.L., Dunstan C.R., et al. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 96 (1999) 3540-3545
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3540-3545
    • Hsu, H.1    Lacey, D.L.2    Dunstan, C.R.3
  • 14
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle W.J., Simonet W.S., and Lacey D.L. Osteoclast differentiation and activation. Nature 423 (2003) 337-342
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 15
    • 0034644474 scopus 로고    scopus 로고
    • Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    • Deng L., Wang C., Spencer E., et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103 (2000) 351-361
    • (2000) Cell , vol.103 , pp. 351-361
    • Deng, L.1    Wang, C.2    Spencer, E.3
  • 16
    • 33947506493 scopus 로고    scopus 로고
    • Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
    • Lamothe B., Besse A., Campos A.D., Webster W.K., Wu H., and Darnay B.G. Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem 282 (2007) 4102-4112
    • (2007) J Biol Chem , vol.282 , pp. 4102-4112
    • Lamothe, B.1    Besse, A.2    Campos, A.D.3    Webster, W.K.4    Wu, H.5    Darnay, B.G.6
  • 17
    • 0037441760 scopus 로고    scopus 로고
    • Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
    • Hideshima T., Mitsiades C., Akiyama M., et al. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood 101 (2003) 1530-1534
    • (2003) Blood , vol.101 , pp. 1530-1534
    • Hideshima, T.1    Mitsiades, C.2    Akiyama, M.3
  • 18
    • 18544367201 scopus 로고    scopus 로고
    • NF-kappa B as a therapeutic target in multiple myeloma
    • Hideshima T., Chauhan D., Richardson P., et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem 277 (2002) 16639-16647
    • (2002) J Biol Chem , vol.277 , pp. 16639-16647
    • Hideshima, T.1    Chauhan, D.2    Richardson, P.3
  • 20
    • 34548128339 scopus 로고    scopus 로고
    • The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma
    • Terpos E., Dimopoulos M.A., and Sezer O. The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma. Leukemia 21 (2007) 1875-1884
    • (2007) Leukemia , vol.21 , pp. 1875-1884
    • Terpos, E.1    Dimopoulos, M.A.2    Sezer, O.3
  • 21
    • 34548029349 scopus 로고    scopus 로고
    • Myeloma bone disease and proteasome inhibition therapies
    • Terpos E., Sezer O., Croucher P., and Dimopoulos M.A. Myeloma bone disease and proteasome inhibition therapies. Blood 110 (2007) 1098-1104
    • (2007) Blood , vol.110 , pp. 1098-1104
    • Terpos, E.1    Sezer, O.2    Croucher, P.3    Dimopoulos, M.A.4
  • 22
    • 33750566914 scopus 로고    scopus 로고
    • Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma
    • Terpos E., Heath D.J., Rahemtulla A., et al. Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma. Br J Haematol 135 (2006) 688-692
    • (2006) Br J Haematol , vol.135 , pp. 688-692
    • Terpos, E.1    Heath, D.J.2    Rahemtulla, A.3
  • 23
    • 38849159333 scopus 로고    scopus 로고
    • Bone building with bortezomib
    • Roodman G.D. Bone building with bortezomib. J Clin Invest 118 (2008) 462-464
    • (2008) J Clin Invest , vol.118 , pp. 462-464
    • Roodman, G.D.1
  • 24
    • 34548133601 scopus 로고    scopus 로고
    • Bortezomib inhibits human osteoclastogenesis
    • von Metzler I., Krebbel H., Hecht M., et al. Bortezomib inhibits human osteoclastogenesis. Leukemia 21 (2007) 2025-2034
    • (2007) Leukemia , vol.21 , pp. 2025-2034
    • von Metzler, I.1    Krebbel, H.2    Hecht, M.3
  • 25
    • 20444441871 scopus 로고    scopus 로고
    • Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function
    • Zavrski I., Krebbel H., Wildemann B., et al. Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function. Biochem Biophys Res Commun 333 (2005) 200-205
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 200-205
    • Zavrski, I.1    Krebbel, H.2    Wildemann, B.3
  • 26
    • 0032508414 scopus 로고    scopus 로고
    • NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • Wang C.Y., Mayo M.W., Korneluk R.G., Goeddel D.V., and Baldwin Jr. A.S. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281 (1998) 1680-1683
    • (1998) Science , vol.281 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin Jr., A.S.5
  • 27
    • 23044506681 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway and its role in cancer
    • Mani A., and Gelmann E.P. The ubiquitin-proteasome pathway and its role in cancer. J Clin Oncol 23 (2005) 4776-4789
    • (2005) J Clin Oncol , vol.23 , pp. 4776-4789
    • Mani, A.1    Gelmann, E.P.2
  • 28
    • 5644259751 scopus 로고    scopus 로고
    • Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains
    • Tenno T., Fujiwara K., Tochio H., et al. Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains. Genes Cells 9 (2004) 865-875
    • (2004) Genes Cells , vol.9 , pp. 865-875
    • Tenno, T.1    Fujiwara, K.2    Tochio, H.3
  • 29
    • 33846031926 scopus 로고    scopus 로고
    • The molecular understanding of osteoclast differentiation
    • Asagiri M., and Takayanagi H. The molecular understanding of osteoclast differentiation. Bone 40 (2007) 251-264
    • (2007) Bone , vol.40 , pp. 251-264
    • Asagiri, M.1    Takayanagi, H.2


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