Blood pressure lowering efficacy of angiotensin converting enzyme (ACE) inhibitors for primary hypertension

Cochrane Database of Systematic Reviews

Volumn , Issue 4, 2008, Pages

  Heran, Balraj S ^a   Wong, Michelle M Y ^b   Heran, Inderjit K ^c   Wright, James M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c VANCOUVER COASTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALACEPRIL; ALTIOPRIL; ALTIOPRIL CALCIUM; BENAZEPRIL; CAPTOPRIL; CERANAPRIL; CILAZAPRIL; DELAPRIL; DERAPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; FELODIPINE; FOSINOPRIL; IDAPRIL; IMIDAPRIL; LISINOPRIL; METOPROLOL; MOEXIPRIL; PENTOPRIL; PERINDOPRIL; PLACEBO; QUINAPRIL; RAMIPRIL; SPIRAPRIL; TEMOCAPRIL; TRANDOLAPRIL; UNCLASSIFIED DRUG; VALSARTAN; ZOFENOPRIL;

AUTHOR; BLOOD PRESSURE VARIABILITY; CLINICAL TRIAL; COCHRANE LIBRARY; COMPARATIVE STUDY; DATA ANALYSIS; DATA EXTRACTION; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG EFFICACY; EMBASE; HEART RATE; HUMAN; HYPERTENSION; INFORMATION PROCESSING; INTERVENTION STUDY; MEDICAL INFORMATION; MEDLINE; MONOTHERAPY; OUTCOME ASSESSMENT; PUBLISHING; QUALITY CONTROL; RECOMMENDED DRUG DOSE; REVIEW; RISK; RISK ASSESSMENT; SYSTOLIC BLOOD PRESSURE;

EID: 55049086960     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD003823.pub2     Document Type: Review

References (173)

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99. Veterans Administration Cooperative Study Group on Antihypertensive Agents. Racial differences in response to low-dose captopril are abolished by the addition of hydrochlorothiazide. British Journal of Clinical Pharmacology 1982;14(Suppl 2):97S-101S.
100. Vandenburg 1994 {published data only} Vandenburg MJ, MacKay EM, Dews I, Pullan T, Brugier S. Dose finding studies with imidapril - a new ACE inhibitor. British Journal of Clinical Pharmacology 1994;37(3):265-72.
101. Vaur 1998 {published data only} Vaur L, Dubroca I, Dutrey-Dupagne C, Genes N, Chatellier G, Bouvier-d'Yvoire M, Elkik F, Menard J. Superiority of home blood pressure measurements over office measurements for testing antihypertensive drugs. Blood Pressure Monitoring 1998;3(2):107-14.
102. Villamil 1987 {published data only} Villamil AS, Cairns V, Witte PU, Bertolasi CA. A double-blind study to compare the efficacy, tolerance and safety of two doses of the angiotensin converting enzyme inhibitor ramipril with placebo. American Journal of Cardiology 1987;59(10):110D-14D.
103. Waeber 1999 {published data only} Waeber B, Detry JM, Dahlof B, Puig JG, Gundersen T, Hosie J, Januszewicz W, Lindstrom CJ, Magometschnigg D, Safar M, Tanser P, Toutouzas P. Felodipine-metoprolol combination tablet: A valuable option to initiate antihypertensive therapy?. American Journal of Hypertension 1999;12(9 Pt 1):915-20.
104. Weinberger 1990 {published data only} Gomez HJ. Dose-response studies with benazepril in mild to moderate hypertension. Clinical Cardiology 1991;14(8 Suppl IV):IV22-7.
105. * Weinberger MH, Black HR, Lasseter KC, Lewis GP, MacLeod CM, Pascual AV, Zager PG, DeSilva J, Gourley LA, Bennett DA, Whalen JJ. Diurnal blood pressure in patients with mild-to-moderate hypertension treated with once-daily benazepril hydrochloride. Clinical Pharmacology and Therapeutics 1990;47(5):608-17.
106. Weir 1995 {published data only} * Weir MR, Gray JM, Paster R, Saunders E. Differing mechanisms of action of angiotensin-converting enzyme inhibition in black and white hypertensive patients. Hypertension 1995;26(1):124-30.
107. Weir MR, Saunders E. Renin status does not predict the anti-hypertensive response to angiotensin-converting enzyme inhibition in African-Americans. Journal of Human Hypertension 1998;12(3):189-94.
108. Whalen 1989 {published data only} Gomez HJ. Dose-response studies with benazepril in mild to moderate hypertension. Clinical Cardiology 1991;14(8 Suppl IV):IV22-7.
109. * Whalen J, Skalky C, DeSilva J, Weber M. Peak and trough effects of 3 once daily dose levels of benazepril inmild-moderate hypertension. American Journal of Hypertension 1989;2(5 Pt 2):45A.
110. Whelton 1992 {published data only} * Whelton A, Dunne Jr B, Glazer N, Kostis JB, Miller WE, Rector DJ, Tresznewsky ON. Twenty-four hour blood pressure effect of once-daily lisinopril, enalapril, and placebo in patients with mild to moderate hypertension. Journal of Human Hypertension 1992;6(4):325-31.
111. White 1988 {published data only} White WB, McCabe EJ, Hager WD, Schulman P. The effects of the long-acting angiotensin-converting enzyme inhibitor cilazapril on casual, exercise, and ambulatory blood pressure. Clinical Pharmacology and Therapeutics 1988;44(2):173-8.
112. White 1995 {published data only} White WB, Whelton A, Fox A, Stimpel M, Kaihlanen PM. Tricenter assessment of the efficacy of the ACE inhibitor, moexipril, by ambulatory blood pressure monitoring. Journal of Clinical Pharmacology 1995;35(3):233-8.
113. White 2002 {published data only} White WB, Sica DA, Calhoun D, Mansoor GA, Anders RJ. Preventing increases in early-morning blood pressure, heart rate, and the rate-pressure product with controlled onset extended release verapamil at bedtime versus enalapril, losartan, and placebo on arising. American Journal of Hypertension 2002;144(4):657-65.
114. Yebes 1993 {published data only} Yebes RB. A placebo-controlled double blind study to evaluate the efficacy of once daily quinapril in patients with mild to moderate hypertension. Philippine Journal of Internal Medicine 1993;31(6):317-26.
115. Yodfat 1993 {published data only} Yodfat Y, Zimilchman R. Dose-finding and dose justification of once-daily cilazapril in combination with hydrochlorothiazide in non-obese patients with mild-to-moderate essential hypertension. Journal of Drug Development 1993;6(3):117-21.
116. Zamboulis 1996 {published data only} Zamboulis C, Karagiannis A, Gotzamani-Psarrakou A, Deligianni K, Spyridonidis T, Fragos S, Psarrakos K. Effects of fosinopril on renal function in patients with mild to moderate essential hypertension. Clinical Drug Investigation 1996;12(5):251-8.
117. Bainbridge 1993 {published data only} Bainbridge AD, MacFadyen RJ, Stark S, Lees KR, Reid JL. The antihypertensive efficacy and tolerability of a low dose combination of ramipril and felodipine ER in mild to moderate essential hypertension. British Journal of Clinical Pharmacology 1993;36(4):323-30.
118. Bakris 2002 {published data only} Bakris G, Sica D, Ram V, Fagan T, Vaitkus PT, Anders RJ. A comparative trial of controlled-onset, extended-release verapamil, enalapril, and losartan on blood pressure and heart rate changes. American Journal of Hypertension 2002;15(1 I):53-7.
119. Beaulieu 1993 {published data only} Beaulieu M, Lacourciere Y, Cleroux J. Unchanged neurogenic vasoconstrictor response after exercise during angiotensin converting enzyme inhibition with fosinopril. American Journal of Hypertension 1994;7(8):763-6.
120. * Beaulieu M, Nadeau A, Lacourciere Y, Cleroux J. Post-exercise reduction in blood pressure in hypertensive subjects: Effects of angiotensin converting enzyme inhibition. British Journal of Clinical Pharmacology 1993;36(4):331-8.
121. Bergstrand 1985 {published data only} Bergstrand R, Herlitz H, Johansson S, Berglund G, Vedin A, Wilhelmsson C, et al.Effective dose range of enalapril in mild to moderate essential hypertension. British Journal of Clinical Pharmacology 1985;19(5):605-11.
122. Bohlen 1996 {published data only} Bohlen L, Bienz R, Doser M, Papiri M, Shaw S, Riesen W, et al.Metabolic neutrality of perindopril: focus on insulin sensitivity in overweight patients with essential hypertension. Journal of Cardiovascular Pharmacology 1996;27(6):770-6.
123. Canter 1994 {published data only} Canter D, Frank GJ, Knapp LE, Phelps M, Quade M, Texter M. Quinapril and hydrochlorothiazide combination for control of hypertension: assessment by factorial design. Quinapril Investigator Group [see comments]. Journal of Human Hypertension 1994;8(3):155-62.
124. Canter 1994a {published data only} Canter DA, Texter MJ, McLain RW. Ambulatory blood pressure monitoring can play an integral role in patient selection, dosage adjustment and efficacy assessment in clinical trials of antihypertensive agents. Journal of Hypertension - Supplement 1994;12(7):S33-8.
125. Cleroux 1994 {published data only} Cleroux J, Beaulieu M, Kouame N, Lacourciere Y. Comparative effects of quinapril, atenolol, and verapamil on blood pressure and forearm hemodynamics during handgrip exercise. American Journal of Hypertension 1994;7(6):566-70.
126. Cuspidi 1997 {published data only} Cuspidi C, Lonati L, Sampieri L, Leonetti G, Muiesan ML, Agabiti-Rosei E, et al.Lack of effect of short-term lisinopril administration on left ventricular filling dynamics in hypertensive patients with diastolic dysfunction. Blood Pressure 1997;6(5):307-12.
127. Duprez 1986 {published data only} Duprez D, Clement DL. Vasodilator effects of enalapril in patients with arterial hypertension. Acta Cardiologica 1986;41(5):359-64.
128. Fagard 2001 {published data only} Fagard R, Lijnen P, Pardaens K, Thijs L, Vinck W. A randomised, placebo-controlled, double-blind, crossover study of losartan and enalapril in patients with essential hypertension. Journal of Human Hypertension 2001;15(3):161-7.
129. Gall 1992 {published data only} Gall MA, Rossing P, Skott P, Hommel E, Mathiesen ER, Gerdes LU, et al.Placebo-controlled comparison of captopril, metoprolol, and hydrochlorothiazide therapy in non-insulin-dependent diabetic patients with primary hypertension. American Journal of Hypertension 1992;5(5 Pt 1):257-65.
130. Gans 1993 {published data only} Gans RO, Stehouwer CD, Bilo HJ, Goggin T, Kraaij CJ, Donker AJ, et al.Effect of cilazapril on glucose tolerance and lipid profile in hypertensive patients with non-insulin-dependent diabetes mellitus. Netherlands Journal of Medicine 1993;43(3-4): 163-73.
131. Gleerup 1996 {published data only} Gleerup G, Petersen JR, Mehlsen J, Winther K. Effect of spirapril and hydrochlorothiazide on platelet function and euglobulin clot lysis time in patients withmild hypertension. Angiology 1996;47(10):951-5.
132. Guitard 1994a {published data only} Guitard C, Alvisi V, Maibach E, Franck J, Cocco G, Boxho G, et al.Placebo-controlled comparison of spirapril at 6, 12 and 24 mg/day in mild to severe essential hypertension. Blood Pressure 1994; Supplement. 2:81-7.
133. Gupta 1990 {published data only} * Gupta RK, Kjeldsen SE, Krause L, Kneisley J, Posvar E, Weder AB, et al.Hemodynamic effects of quinapril, a novel angiotensin-converting enzyme inhibitor. Clinical Pharmacology & Therapeutics 1990;48(1):41-9.
134. Gupta RK, Kjeldsen SE, Motley E, Weder AB, Zweifler AJ, Julius S. Platelet function during antihypertensive treatment with quinapril, a novel angiotensin converting enzyme inhibitor. Journal of Cardiovascular Pharmacology 1991;17(1):13-9.
135. Homuth 1993a {published data only} Homuth V, Faulhaber HD, Loose U, Loffler K, Luft FC. Usefulness of piretanide plus ramipril for systemic hypertension: a multicenter trial. American Journal of Cardiology 1993;72(9):666-71.
136. Hu 1999 {published data only} Hu Y, Zhu J. Quality of life of patients with mild hypertension treated with captopril: A randomized double-blind placebo-controlled clinical trial. Chinese Medical Journal 1999;112(4):302-7.
137. Kahan 1999 {published data only} Kahan T, Eliasson K. The influence of long-term ACE inhibitor treatment on circulatory responses to stress in human hypertension. American Journal of Hypertension 1999;12(12 I):1188-94.
138. Karlberg 1987 {published data only} Karlberg BE, Lindstrom T, Rosenqvist U, Ohman KP. Efficacy, tolerance and hormonal effects of a new oral angiotensin converting enzyme inhibitor, ramipril (HOE 498), in mild to moderate primary hypertension. American Journal of Cardiology 1987;59(10):104D-9D.
139. Kjeldsen 1992 {published data only} Kjeldsen SE, Gupta RK, Krause L, Weder AB, Julius S. Does blood pressure reduction necessarily compromise cardiac function or renal hemodynamics? Effects of the angiotensin-converting enzyme inhibitor quinapril. American Heart Journal 1992;123(5):1433-8.
140. Lacourciere 1999 {published data only} Lacourciere Y, Bittar N, Blanchard E, Kilpatrick FW, Schumacher D, Chappel C, et al.The incidence of cough: A comparison of lisinopril, placebo and telmisartan, a novel angiotensin II antagonist. International Journal of Clinical Practice 1999;53(2):99-103.
141. Lavezzaro 1990 {published data only} Lavezzaro G, Ladetto PE, Valente M, Stramignoni D, Zanna C, Assogna G, et al.Ketanserin and captopril interaction in the treatment of essential hypertensives. Cardiovascular Drugs & Therapy 1990;4 (SUPPL. 1):119-22.
142. Leonetti 1991 {published data only} Leonetti G, Mazzola C, Pasotti C, Angioni L, Vaccarella A, Capra A, et al.Treatment of hypertension in the elderly: Effects on blood pressure, heart rate, and physical fitness. American Journal of Medicine 1991;90(SUPPL.3A):12S-3S.
143. Littler 1990 {published data only} Littler WA, West JW. Twenty-four hour action of ACE inhibitors. Journal of Human Hypertension 1990;4(SUPPL. 4):13-6.
144. Louis 1992 {published data only} Louis WJ, Workman BS, Conway EL, Worland P, Rowley K, Drummer O, et al.Single-dose and steady-state pharmacokinetics and pharmacodynamics of perindopril in hypertensive subjects. Journal of Cardiovascular Pharmacology 1992;20(3):505-11.
145. Miyajima 1999 {published data only} Miyajima E, Shigemasa T, Yamada Y, Tochikubo O, Ishii M. Angiotensin II blunts, while an angiotensin-converting enzyme inhibitor augments, reflex sympathetic inhibition in humans. Clinical & Experimental Pharmacology & Physiology 1999;26(10):797-802.
146. Morgan 2001 {published data only} Morgan TO, Anderson AI, MacInnis RJ. ACE inhibitors, beta-blockers, calcium blockers, and diuretics for the control of systolic hypertension. American Journal of Hypertension 2001;14(3):241-7.
147. Petersen 1996 {published data only} Petersen JR, Drabaek H, Gleerup G, Mehlsen J, Petersen LJ, Winther K. ACE inhibition with spirapril improves diastolic function at rest independent of vasodilation during treatment with spirapril in mild to moderate hypertension. Angiology 1996;47(3):233-40.
148. Petrie 2000 {published data only} Petrie JR, Morris AD, Ueda S, Small M, Donnelly R, Connell JM, et al.Trandolapril does not improve insulin sensitivity in patients with hypertension and type 2 diabetes: a double-blind, placebo-controlled crossover trial. Journal of Clinical Endocrinology & Metabolism 2000;85(5):1882-9.
149. Petrov 2001 {published data only} Petrov VV, Fagard RH, Lijnen PJ. T-lymphocyte and plasma angiotensin-converting enzyme activity during enalapril and losartan administration in humans. Journal of Cardiovascular Pharmacology 2001;38(4):578-83.
150. Plouin 1991 {published data only} Plouin PF, Battaglia C, Alhenc-Gelas F, Corvol P. Are angiotensin converting enzyme inhibition and aldosterone antagonism equivalent in hypertensive patients over fifty?. American Journal of Hypertension 1991;4(4 Pt 1):356-62.
151. Pritchard 1996 {published data only} Pritchard G, Lyons D, Webster J, Petrie JC, Ma trandolapril and indomethacin influence renal function and renal functional reserve in hypertensive patients?. British Journal of Clinical Pharmacology 1997;44(2):145-9.
152. * Pritchard G, Lyons D, Webster J, Petrie JC, MacDonald TM. Indomethacin does not attenuate the hypotensive effect of trandolapril. Journal of Human Hypertension 1996;10(11):763-7.
153. Reisin 1997 {published data only} Reisin E, Weir MR, Falkner B, Hutchinson HG, Anzalone DA, Tuck ML. Lisinopril versus hydrochlorothiazide in obese hypertensive patients: a multicenter placebo-controlled trial. Treatment in Obese Patients With Hypertension (TROPHY) Study Group. Hypertension 1997;30(1 Pt 1):140-5.
154. Salvetti 1987 {published data only} Salvetti A, Innocenti PF, Iardella M, Pambianco F, Saba GC, Rossetti M, et al.Captopril and nifedipine interactions in the treatment of essential hypertensives: a crossover study. Journal of Hypertension - Supplement 1987;5(4):S139-42.
155. Salvetti 1988 {published data only} Salvetti A, Circo A, Raciti S, Gulizia M, Cardillo R, Miceli S, et al.Captopril at 50 mg as well as at 100 mg once a day reduces blood pressure for up to 24 h: a double-blind randomized crossover study in mild to moderate hypertensives. Journal of Hypertension - Supplement 1988;6(4):S666-8.
156. Salvetti 1989 {published data only} Salvetti A, Arzilli F. Chronic dose-response curve of enalapril in essential hypertensives. An Italian multicenter study. American Journal of Hypertension 1989;2(5 Pt 1):352-4.
157. Samuelsson 1992 {published data only} Samuelsson O, Hedner T, Ljungman S, Herlitz H, Widgren B, Pennert K. A comparative study of lisinopril and atenolol on low degree urinary albumin excretion, renal function and haemodynamics in uncomplicated, primary hypertension. European Journal of Clinical Pharmacology 1992;43(5):469-75.
158. Sassano 1984a {published data only} Sassano P, Chatellier G, Amiot AM, Alhenc-Gelas F, Corvol P, Menard J. A double-blind randomized evaluation of converting enzyme inhibition as the first-step treatment of mild to moderate hypertension. Journal of Hypertension - Supplement 1984;2(2):S75-80.
159. Scholze 1993 {published data only} Scholze J, Breitstadt A, Cairns V, Bauer B, Bender N, Priestley C, et al.Short report: ramipril and hydrochlorothiazide combination therapy in hypertension: a clinical trial of factorial design. The East Germany Collaborative Trial Group. Journal of Hypertension 1993;11(2):217-21.
160. Thurig 1995 {published data only} Thurig C, Bohlen L, Schneider M, de Courten M, Shaw SG, Riesen W, et al.Lisinopril is neutral to insulin sensitivity and serum lipoproteins in essential hypertensive patients. European Journal of Clinical Pharmacology 1995;49(1-2):21-6.
161. Tomei 1992 {published data only} Tomei R, Rossi L, Carbonieri E, Franceschini L, Molon G, Zardini P. Antihypertensive effect of lisinopril assessed by 24-hour ambulatory monitoring: a double-blind, placebo-controlled, cross-over study. Journal of Cardiovascular Pharmacology 1992;19(6):911-4.
162. Wiggam 1998 {published data only} Wiggam MI, Hunter SJ, Atkinson AB, Ennis CN, Henry JS, Browne JN, et al.Captopril does not improve insulin action in essential hypertension: a double-blind placebo-controlled study. Journal of Hypertension 1998;16(11):1651-7.
163. Wilkins 1983 {published data only} Wilkins LH, Dustan HP, Walker JF, Oparil S. Enalapril in low-renin essential hypertension. Clinical Pharmacology & Therapeutics 1983;34(3):297-302.
164. Wing 1987 {published data only} Wing LM, Chalmers JP, West MJ, Bune AJ, Russell AE, Elliott JM, et al.Treatment of hypertension with enalapril and hydrochlorothiazide or enalapril and atenolol: contrasts in hypotensive interactions. Journal of Hypertension - Supplement 1987;5(5):S603-6.
165. Wing 1988 {published data only} Wing LM, Chalmers JP, West MJ, Russell AE, Morris MJ, Cain MD, et al.Enalapril and atenolol in essential hypertension: attenuation of hypotensive effects in combination. Clinical & Experimental Hypertension - Part A, Theory & Practice 1988;10(1):119-33.
166. Youssef 1993 {published data only} Youssef S, Osman L, Sabbour MS. Serum lipoprotein profile under different antihypertensive therapy. Cardiovascular Risk Factors 1993; 3(2):107-11.
167. Zanchetti 2001 {published data only} Zanchetti A, Omboni S. Comparison of candesartan versus enalapril in essential hypertension. Italian Candesartan Study Group. American Journal of Hypertension 2001;14(2):129-34.
168. Bucher 1997 Bucher HC, Guyatt GH, Griffith LE, Walter D. The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. Journal of Clinical Epidemiology 1997;50(6):683-91.
169. Cochrane Handbook Sterne JAC, Egger M, Moher D (editors). Chapter 10: Addressing reporting biases. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Intervention. The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org, Version 5.0.0 (updated February 2008).
170. Heran 2002 Heran BS, Jauca CD, Wright JM. Development of an optimal search strategy for finding trials demonstrating ACE inhibitor blood pressure lowering efficacy. 10th International Cochran Colloquium, Stavenger, Norway 2002.
171. Jadad 1996 88.Jadad AR, Moore RA, Carrol D, et al.Assessing the quality of reports of randomized clinical trials: Is blinding necessary?. Controlled Clinical Trials 1996;17:1-12.
172. Song 2003 Song F, Altman DG, Glenny AM Deeks JJ. Validity of indirect comparison for estimating efficacy of competing interventions: emperical evidence from published meta-analyses. British Medical Journal 2003;326:472-76.
173. WHO-ICTRP World Health Organization. International Clinical Trials Registry Platform (ICTRP). Available from: http://www.who.int/ictrp/en 2006 [cited 2008 Feb 29].