Does oral magnesium substitution relieve pregnancy-induced leg cramps?

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 141, Issue 1, 2008, Pages 23-26

  Nygaard, Ingerid Herstad ^a   Valbø, Annelill ^a   Pethick, Sigrid Vingerhagen ^b   Bøhmer, Thomas ^c  

^a VESTRE VIKEN HOSPITAL TRUST   (Norway)

^b Sykehuset Buskerud HF   (Norway)

^c AKER UNIVERSITY HOSPITAL   (Norway)

Author keywords

Leg cramps; Magnesium; Pregnancy

Indexed keywords

CALCIUM; MAGNESIUM; PLACEBO;

ADULT; ARTICLE; CALCIUM BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FLATULENCE; HUMAN; LEG CRAMP; MAGNESIUM BLOOD LEVEL; MAGNESIUM EXCRETION; MAGNESIUM URINE LEVEL; NAUSEA; PAIN ASSESSMENT; PREGNANCY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 54949159187     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2008.07.005     Document Type: Article

References (20)

1. Salvatore C. Leg cramp syndrome in pregnancy. Obstet Gynecol 17 (1961) 634-639
2. Goodman J.D.S.B.C., and Avida G.A. Restless legs syndrome in pregnancy. BMJ 297 (1988) 1101-1102
3. Bracken M.E.M., Campbell H., and Chalmers I. Symptoms in pregnancy: nausea and vomiting, heartburn constipation and leg cramps (1989), Oxford University Press, New York
4. Valbø A.B.T. Pregnancy induced leg cramps how common are they?. Tidsskr Nor Legeforen 119 11 (1999) 1589-1590
5. Riss P.B.W., and Jelincic D. Clinical aspects and treatment of calf muscle cramps during pregnancy. Geburtshilfe Frauenheilkd 43 5 (1983) 329-331
6. Williams J.W. Obstetrics. 17th ed. (1985), Appleton-Century-Crofts, Norwalk Connecticut
7. Robinson M. Cramps in pregnancy. J Obstet Gynecol Br Empire 54 (1947) 826-829
8. Page E.W.P.E. Leg cramps in pregnancy. Obstet Gynecol 1 (1953) 94-100
9. Norris F.H.C.E., and Chatfield P.O. An electromyographic study of induced and spontaneous muscle cramps. Electroencephalogr Clin Neurophysiol 9 (1957) 139
10. Kleine H.D. Laktoflavintherapie der wadenkrampfe in der schwangerschaft. Zentralbl Gynäk 76 (1954) 344
11. Lancome M.L.F., and Guesguen J. Action de la cocarboxylase sur les crampes et certain troubles paresthétiques de la femme enceintes. Gynéc et Obst 4 (1952) 230
12. Graber T.W.Y.A., and Baker F.J. Magnesium: physiology, clinical disorders, and therapy. Am Emerg Med 10 (1981) 49-57
13. Hammar M.L.L., and Tegler L. Calcium treatment of leg cramps in pregnancy. Acta Obstet Gynecol Scand 60 (1981) 345-347
14. Dahle L.O.B.G., Hammar M., Hurtig M., and Larsson L. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol 173 (1995) 175-180
15. Flink E.B. Magnesium deficiency: etiology and clinical spectrum. Acta med Scand 647 Suppl. (1980) 125-137
16. Nordic Council of Ministers. Nordic Nutrition Recommendations. Scand J Nutr 1996;40:161-5.
17. Young GL JD, Interventions for leg cramps in pregnancy. Cochrane database Syst Rev 2002;1 (CD000121).
18. Frusso R., Zarate M., Augustovski F., and Rubinstein A. Magnesium for the treatment of noctural leg cramps: a crossover randomized trial. J Fam Pract 48 11 (1999) 868-871
19. Roffe C., Sills S., Crome P., and Jones P. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit 8 5 (2002) 326-330
20. Dahlman T.S.H., and Bucht E. Calcium homeostasis in normal pregnancy and puerperium. Acta Obstet Gynecol Scand 73 (1994) 393-398