-
1
-
-
0022365046
-
Self-phospholylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor
-
PJ Bertics GN Gill 1985 Self-phospholylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor J Biol Chem 260 14642 14647
-
(1985)
J Biol Chem
, vol.260
, pp. 14642-14647
-
-
Bertics, P.J.1
Gill, G.N.2
-
2
-
-
0023873922
-
Alteration of epidermal growth factor receptor activity by mutation of its primary carboxyl-terminal site of tyrosine self-phosphorylation
-
PJ Bertics WS Chen L Hubler CS Lazar MG Rosenfeld GN Gill 1988 Alteration of epidermal growth factor receptor activity by mutation of its primary carboxyl-terminal site of tyrosine self-phosphorylation J Biol Chem 263 3610 3617
-
(1988)
J Biol Chem
, vol.263
, pp. 3610-3617
-
-
Bertics, P.J.1
Chen, W.S.2
Hubler, L.3
Lazar, C.S.4
Rosenfeld, M.G.5
Gill, G.N.6
-
3
-
-
0030029314
-
Nucleotide binding by the epidermal growth factor receptor protein-tyrosine kinase. Trinitrophenyl-ATP as a spectroscopic probe
-
K Cheng JG Koland 1996 Nucleotide binding by the epidermal growth factor receptor protein-tyrosine kinase. Trinitrophenyl-ATP as a spectroscopic probe J Biol Chem 271 311 318
-
(1996)
J Biol Chem
, vol.271
, pp. 311-318
-
-
Cheng, K.1
Koland, J.G.2
-
4
-
-
33644539850
-
Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay
-
K Endo A Konishi H Sasaki M Takada H Tanaka M Okumura M Kawahara H Sugiura Y Kuwabara I Fukai A Matsumura M Yano Y Kobayashi K Mizuno H Haneda E Suzuki K Iuchi Y Fujii 2005 Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay Lung Cancer 50 375 384
-
(2005)
Lung Cancer
, vol.50
, pp. 375-384
-
-
Endo, K.1
Konishi, A.2
Sasaki, H.3
Takada, M.4
Tanaka, H.5
Okumura, M.6
Kawahara, M.7
Sugiura, H.8
Kuwabara, Y.9
Fukai, I.10
Matsumura, A.11
Yano, M.12
Kobayashi, Y.13
Mizuno, K.14
Haneda, H.15
Suzuki, E.16
Iuchi, K.17
Fujii, Y.18
-
5
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
M Fukuoka S Yano G Giaccone T Tamura K Nakagawa JY Douillard Y Nishiwaki J Vansteenkiste S Kudoh D Rischin R Eek T Horai K Noda I Takata E Smit S Averbuch A Macleod A Feyereuslova RP Dong J Baselga 2003 Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer J Clin Oncol 21 2237 2246
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.Y.6
Nishiwaki, Y.7
Vansteenkiste, J.8
Kudoh, S.9
Rischin, D.10
Eek, R.11
Horai, T.12
Noda, K.13
Takata, I.14
Smit, E.15
Averbuch, S.16
MacLeod, A.17
Feyereuslova, A.18
Dong, R.P.19
Baselga, J.20
more..
-
7
-
-
0002384775
-
Cancer of the lung
-
Lippincott, Philadelphia
-
Ginsberg RJ, Kris K, Armstrong G (1993) Cancer of the lung. In: Principles and practice of oncology, 4th edn. Lippincott, Philadelphia, pp 673-682
-
(1993)
Principles and Practice of Oncology, 4th Edn.
, pp. 673-682
-
-
Ginsberg, R.J.1
Kris, K.2
Armstrong, G.3
-
8
-
-
21044445894
-
Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-alpha (TGFA) gene and risk of oral cancer in Puerto Rico
-
D Kang G Gridley WY Huang LS Engel DM Winn LM Brown E Bravo-Otero T Wu SR Diehl RB Hayes 2005 Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-alpha (TGFA) gene and risk of oral cancer in Puerto Rico Pharmacogenet Genomics 15 343 347
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 343-347
-
-
Kang, D.1
Gridley, G.2
Huang, W.Y.3
Engel, L.S.4
Winn, D.M.5
Brown, L.M.6
Bravo-Otero, E.7
Wu, T.8
Diehl, S.R.9
Hayes, R.B.10
-
9
-
-
10844231985
-
Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
-
T Kosaka Y Yatabe H Endoh H Kuwano T Takahashi T Mitsudomi 2004 Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications Cancer Res 64 8919 8923
-
(2004)
Cancer Res
, vol.64
, pp. 8919-8923
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
Kuwano, H.4
Takahashi, T.5
Mitsudomi, T.6
-
10
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non small cell lung cancer: Randomized trial
-
MG Kris RB Natale RS Herbst TJ Lynch D Prager CP Belani JH Schiller K Kelly H Spiridonidis A Sandler KS Albain D Cella MK Wolf SD Averbuch JJ Ochs AC Kay 2003 Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non small cell lung cancer: randomized trial JAMA 290 2149 2158
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch, T.J.4
Prager, D.5
Belani, C.P.6
Schiller, J.H.7
Kelly, K.8
Spiridonidis, H.9
Sandler, A.10
Albain, K.S.11
Cella, D.12
Wolf, M.K.13
Averbuch, S.D.14
Ochs, J.J.15
Kay, A.C.16
-
11
-
-
9944246020
-
A putative mechanism for downregulation of the catalytic activity of the EGF receptor via direct contact between its kinase and C-terminal domains
-
M Landau SJ Fleishman N Ben-Tal 2004 A putative mechanism for downregulation of the catalytic activity of the EGF receptor via direct contact between its kinase and C-terminal domains Structure 12 2265 2275
-
(2004)
Structure
, vol.12
, pp. 2265-2275
-
-
Landau, M.1
Fleishman, S.J.2
Ben-Tal, N.3
-
12
-
-
33646137141
-
Structure and dynamics of the epidermal growth factor receptor C-terminal phopshorylation domain
-
NY Lee TL Hazlett JG Koland 2006 Structure and dynamics of the epidermal growth factor receptor C-terminal phopshorylation domain Protein Sci 15 1142 1152
-
(2006)
Protein Sci
, vol.15
, pp. 1142-1152
-
-
Lee, N.Y.1
Hazlett, T.L.2
Koland, J.G.3
-
13
-
-
40949096067
-
Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib
-
G Liu S Gurubhagavatula W Zhou Z Wang BY Yeap K Asomaning L Su R Heist TJ Lynch DC Christiani 2008 Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib Pharmacogenomics J 8 129 138
-
(2008)
Pharmacogenomics J
, vol.8
, pp. 129-138
-
-
Liu, G.1
Gurubhagavatula, S.2
Zhou, W.3
Wang, Z.4
Yeap, B.Y.5
Asomaning, K.6
Su, L.7
Heist, R.8
Lynch, T.J.9
Christiani, D.C.10
-
14
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
TJ Lynch DW Bell R Sordella S Gurubhagavatula RA Okimoto BW Branniga PL Harris SM Haserlat JG Supko FG Haluska DN Louis DC Christiani J Settleman DA Haber 2004 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib New Engl J Med 350 2129 2139
-
(2004)
New Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Branniga, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
15
-
-
20044364933
-
EGFR mutations in non-small-cell lung cancer: Analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
-
A Marchetti C Martella L Felicioni F Barassi S Salvatore A Chella PP Camplese T Iarussi F Muchilli A Mezzetti F Cuccurullo R Sacco F Buttitta 2005 EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment J Clin Onlol 23 857 865
-
(2005)
J Clin Onlol
, vol.23
, pp. 857-865
-
-
Marchetti, A.1
Martella, C.2
Felicioni, L.3
Barassi, F.4
Salvatore, S.5
Chella, A.6
Camplese, P.P.7
Iarussi, T.8
Muchilli, F.9
Mezzetti, A.10
Cuccurullo, F.11
Sacco, R.12
Buttitta, F.13
-
16
-
-
1842509828
-
Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer
-
VA Miller MG Kris N Shah J Patel C Azzoli J Gomez LM Krug W Pao N Rizvi B Pizzo L Tyson E Venkatraman L Ben-Porat N Memoli M Zakowski V Rusch RT Heelan 2004 Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer J Clin Oncol 22 1103 1109
-
(2004)
J Clin Oncol
, vol.22
, pp. 1103-1109
-
-
Miller, V.A.1
Kris, M.G.2
Shah, N.3
Patel, J.4
Azzoli, C.5
Gomez, J.6
Krug, L.M.7
Pao, W.8
Rizvi, N.9
Pizzo, B.10
Tyson, L.11
Venkatraman, E.12
Ben-Porat, L.13
Memoli, N.14
Zakowski, M.15
Rusch, V.16
Heelan, R.T.17
-
18
-
-
1642453746
-
Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer
-
A Onn AM Correa M Gilcrease T Isobe E Massarelli CD Bucane MS O'Reilly WK Hong IJ Fidler JB Putnum RS Herbst 2004 Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer Clin Cancer Res 10 136 143
-
(2004)
Clin Cancer Res
, vol.10
, pp. 136-143
-
-
Onn, A.1
Correa, A.M.2
Gilcrease, M.3
Isobe, T.4
Massarelli, E.5
Bucane, C.D.6
O'Reilly, M.S.7
Hong, W.K.8
Fidler, I.J.9
Putnum, J.B.10
Herbst, R.S.11
-
19
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
JG Paez PA Janne JC Lee S Tracy H Greulich S Gabriel P Herman FJ Kaye N Lindeman TJ Boggon K Naoki H Sasaki Y Fujii MJ Eck WR Seller BE Johnson M Meyerson 2004 EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 1497 1500
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Seller, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
20
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and elrotinib
-
W Pao V Miller M Zakowski J Doherty K Politi I Sarkari R Heelan V Rusch L Fulton E Mardis D Kupfer R Wilson M Kri H Varmus 2004 EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and elrotinib Proc Natl Acad Sci USA 101 13306 13311
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkari, I.6
Heelan, R.7
Rusch, V.8
Fulton, L.9
Mardis, E.10
Kupfer, D.11
Wilson, R.12
Kri, M.13
Varmus, H.14
-
21
-
-
20244371965
-
EGFR mutation status in Japanese lung cancer patients: Genotyping analysis using LighyCycler
-
H Sasaki K Endo A Konishi M Takada M Kawahara K Iuchi A Matsumura M Okumura H Tanaka T Kawaguchi T Shimizu H Takeuchi M Yano I Fukai Y Fujii 2005 EGFR mutation status in Japanese lung cancer patients: genotyping analysis using LighyCycler Clin Cancer Res 11 2924 2929
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2924-2929
-
-
Sasaki, H.1
Endo, K.2
Konishi, A.3
Takada, M.4
Kawahara, M.5
Iuchi, K.6
Matsumura, A.7
Okumura, M.8
Tanaka, H.9
Kawaguchi, T.10
Shimizu, T.11
Takeuchi, H.12
Yano, M.13
Fukai, I.14
Fujii, Y.15
-
22
-
-
27944499351
-
EGFR and erbB2 mutation status in Japanese lung cancer patients
-
H Sasaki S Shimizu K Endo M Takada M Kawahara H Tanaka A Matsumura K Iuchi H Haneda E Suzuki Y Kobayashi M Yano Y Fujii 2006 EGFR and erbB2 mutation status in Japanese lung cancer patients Int J Cancer 118 180 184
-
(2006)
Int J Cancer
, vol.118
, pp. 180-184
-
-
Sasaki, H.1
Shimizu, S.2
Endo, K.3
Takada, M.4
Kawahara, M.5
Tanaka, H.6
Matsumura, A.7
Iuchi, K.8
Haneda, H.9
Suzuki, E.10
Kobayashi, Y.11
Yano, M.12
Fujii, Y.13
-
23
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutation in lung cancers
-
H Shigematsu L Lin T Takahashi M Numura M Suzuki II Wistuba KM Fong H Lee S Toyooka N Shimizu T Fujisawa Z Feng JA Roth J Herz JD Minna AF Gazdar 2005 Clinical and biological features associated with epidermal growth factor receptor gene mutation in lung cancers J Natl Cancer Inst 97 339 346
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
Numura, M.4
Suzuki, M.5
Wistuba, I.I.6
Fong, K.M.7
Lee, H.8
Toyooka, S.9
Shimizu, N.10
Fujisawa, T.11
Feng, Z.12
Roth, J.A.13
Herz, J.14
Minna, J.D.15
Gazdar, A.F.16
-
24
-
-
0033566893
-
Intragenic mutation analysis of the human epidermal growth factor receptor (EGFR) gene in malignant human oral keratinocytes
-
S Shintani K Matsuo CC Crohin J McBride T Tsuji RB Donoff M Posner R Todd DT Wong 1999 Intragenic mutation analysis of the human epidermal growth factor receptor (EGFR) gene in malignant human oral keratinocytes Cancer Res 59 4142 4147
-
(1999)
Cancer Res
, vol.59
, pp. 4142-4147
-
-
Shintani, S.1
Matsuo, K.2
Crohin, C.C.3
McBride, J.4
Tsuji, T.5
Donoff, R.B.6
Posner, M.7
Todd, R.8
Wong, D.T.9
-
25
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advance non-small-cell lung cancer: Result from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
N Thatcher A Chang P Purvish J Rodrigues Pereira T Ciuleanu J von Pawel EH Tan K Pemberton V Archer K Carroll 2005 Gefitinib plus best supportive care in previously treated patients with refractory advance non-small-cell lung cancer: result from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer) Lancet 366 1527 1537
-
(2005)
Lancet
, vol.366
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Purvish, P.3
Rodrigues Pereira, J.4
Ciuleanu, T.5
Von Pawel, J.6
Tan, E.H.7
Pemberton, K.8
Archer, V.9
Carroll, K.10
-
26
-
-
19944433797
-
The relationship between epidermal growth factor receptor mutation and clinicopathological feature in non-small cell lung cancers
-
M Tokumo S Toyooka K Kiura H Shigematsu K Tomii M Aoe K Ichimura T Tsuda M Yano K Tsukuda M Tabata H Ueoka M Tanimoto H Date AF Gazder N Shimizu 2005 The relationship between epidermal growth factor receptor mutation and clinicopathological feature in non-small cell lung cancers Clin Cancer Res 11 1167 1173
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1167-1173
-
-
Tokumo, M.1
Toyooka, S.2
Kiura, K.3
Shigematsu, H.4
Tomii, K.5
Aoe, M.6
Ichimura, K.7
Tsuda, T.8
Yano, M.9
Tsukuda, K.10
Tabata, M.11
Ueoka, H.12
Tanimoto, M.13
Date, H.14
Gazder, A.F.15
Shimizu, N.16
-
28
-
-
34548037952
-
Identification of EGF receptor C-terminal sequence 1005-1017 and di-leucine motif (1010) LL(1011) as essential in EGF receptor endocytosis
-
Q Wang F Zhu Z Wang 2007 Identification of EGF receptor C-terminal sequence 1005-1017 and di-leucine motif (1010) LL(1011) as essential in EGF receptor endocytosis Exp Cell Res 313 3349 3363
-
(2007)
Exp Cell Res
, vol.313
, pp. 3349-3363
-
-
Wang, Q.1
Zhu, F.2
Wang, Z.3
|